Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC IIQLPEIVVV TFA | 99.9% | 1122.40 | 1 MG
IIQLPEIVVV TFA is a specific inhibitor of Drp1-Mff interaction. It can distinguish physiological from pathological fission and block physiological fission, leading to mitochondrial dysfunction. It can be used in the study of Huntington's disease.
- Specific inhibitor of Drp1-Mff interaction
- Distinguishes physiological from pathological fission
- Blocks physiological fission
- Leads to mitochondrial dysfunction
- Used in the study of Huntington's disease
- Purity of 99.91%
- White to off-white solid appearance
- Sequence: Ile-Ile-Gln-Leu-Pro-Glu-Ile-Val-Val-Val
Medchemexpress LLC Tcmcb07 (TFA) | 99.7% | 1230.46 (free base) | 5 MG
TCMCB07 (TFA) is a chemical product from MedChemExpress USA, identified for use as laboratory chemicals and for the manufacture of substances. It is supplied as a solid and is stable under recommended storage conditions.
- Designed for laboratory use and substance manufacturing
- Stable under recommended storage conditions
- Supplied as a solid
- Storage recommended at -80°C for 2 years or -20°C for 1 year (powder)
- Sealed storage, away from moisture and light
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397384.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 5 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue that acts as a GnRH receptor agonist. It inhibits the growth of experimental prostate cancer in rats.
- Acts as a GnRH receptor agonist
- Inhibits the growth of experimental prostate cancer in rats
Medchemexpress LLC Glycyl-exatecan TFA | 1883333-57-0 | 96.9% | 606.52 g/mol | C28H26F4N4O7 | 5 MG
Glycyl-exatecan TFA is a synthetic trifluoroacetate salt derivative of exatecan used as an experimental anticancer compound in research. It is supplied in solid and DMSO solution formats for in vitro and in vivo pharmacology studies; consult supplier documentation and the SDS for handling and storage guidelines.
- Trifluoroacetate salt form.
- Molecular formula C28H26F4N4O7.
- Molecular weight 606.52 g/mol.
- Purity typically around 96.9%.
- Available in small-scale sizes and 10 mM DMSO solutions.
- Intended for research use only in oncology and pharmacology.
- Handle according to SDS and laboratory safety procedures.
Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | >98.0% | 1 ML
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with anti-cancer activity, designed for research applications.
- Potent and orally active dual JAK2/FLT3 inhibitor.
- Exhibits anti-cancer activity.
- Down-regulates p-FLT3 in a dose-dependent manner.
- Induces apoptosis and cell cycle arrest in MV4-11 cells.
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 250G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 250G
Medchemexpress LLC Glycyl-exatecan (TFA) | 1883333-57-0 | 96.9% | 100 MG
Glycyl-Exatecan TFA is a derivative of Exatecan, known for its significant antitumor activity. This compound acts as an anticancer agent and is suitable for research applications, particularly in studies involving solid tumors.
- Acts as an anticancer agent
- Exhibits significant antitumor activity
- Suitable for solid tumors research
- Derivative of Exatecan
eMolecules 407-25-0 | Trifluoroacetic anhydride | Chem-Impex | MFCD00000416 | 210.031 | C4F6O3 | 99.000 | FC(F)(F)C(=O)OC(=O)C(F)(F)F | 25g | 322127108
Trifluoroacetic anhydride | Chem-Impex | 407-25-0 | MFCD00000416 | 210.031 | C4F6O3 | 99.000 | FC(F)(F)C(=O)OC(=O)C(F)(F)F | 25g | 322127108
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 500 UG
Dendrotoxin-I TFA is a potent K+ channel blocker effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6, with IC50s ranging from 0.13-50 nM. This neurotoxin holds potential in cancer research, as demonstrated by its significant tumor growth inhibition effect when combined with hyperthermia in nude mice with MCF-7 cells.
- Potent K+ channel blocker
- Effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6
- Exhibits neurotoxic properties
- Potential for use in cancer research
- Demonstrated tumor growth inhibition in in vivo studies