Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Z-VRPR-FMK TFA (VRPR) | 95.0% | 790.81 | 200 UG
Z-VRPR-FMK TFA (VRPR) is a tetrapeptide and a selective, irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 1 MG
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Tetrapeptide
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Calcitonin, eel TFA | 99.9% | 3528.89 | 5 MG
Calcitonin, eel TFA is a thyroid hormone peptide that plays a role in regulating calcium homeostasis. It is frequently used in research concerning postmenopausal osteoporosis. In vitro studies show that Calcitonin, eel stimulates phosphoinositide hydrolysis and prolactin release in cultured anterior pituitary cells more effectively than salmon calcitonin. However, it does not inhibit prolactin release under conditions stimulated by thyrotropin releasing hormone (TRH).
- Contributes to the regulation of calcium homeostasis.
- Widely used in postmenopausal osteoporosis research.
- Effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis in vitro.
- Stimulates prolactin release in cultured anterior pituitary cells in vitro.
- High purity of 99.91%.
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 1 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels. It inhibits glutamate exocytosis and calcium influx induced by high potassium, and blocks the high potassium-induced release of serotonin and norepinephrine. This compound does not affect L-type or N-type calcium channels.
- Potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels
- Inhibits glutamate exocytosis and calcium influx induced by high potassium
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
Medchemexpress LLC Dendrotoxin-I (TFA) | 99.9% | 7149.24 | 5 MG
Dendrotoxin-I (DTX-I) TFA is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6. This neurotoxin has potential for cancer research.
- Potent K+ channel blocker.
- Targets voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6.
- Potential for cancer research.
- Shows significant tumor growth inhibition effect in nude mice with MCF-7 cells when combined with hyperthermia (at 5 mg/kg IV).
Medchemexpress LLC Api137 TFA | 1428789-03-0 | 2291.71 | 1 MG
Api137 is an antimicrobial peptide designed to interfere with bacterial growth by inhibiting translation. It achieves this by trapping release factors on the 70S ribosome after the nascent polypeptide chain has been hydrolyzed, thereby preventing protein synthesis.
- Antimicrobial activity: effectively interferes with bacterial growth
- Translation inhibition: specific action on protein synthesis by targeting ribosomal release factors
- Research use only: intended for research purposes
- TFA form availability: available in a TFA (trifluoroacetate) form
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 | C25H31F3N12O10S2 | 5 MG
Ceftolozane TFA is the trifluoroacetic acid (TFA) salt of a cephalosporin antibiotic supplied as a solid for research use. It is used to study and inhibit Gram-negative bacterial infections and as a synthetic building block for development of new antibiotic derivatives.
- Cephalosporin-class antibiotic active against Gram-negative bacteria.
- Useful as a synthetic intermediate for antibiotic development.
- High purity (98.2%) suitable for analytical and synthetic work.
- White to off-white solid form for easy handling and storage.
- Available in milligram-scale quantities for research applications.
- Store at -20°C sealed; in solvent, store at -80°C up to 6 months or -20°C up to 1 month.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Ceftolozane TFA 1mg | 1628046-32-1 | 1MG
Ceftolozane TFA is a cephalosporin antibiotic that can be used to inhibit Gram-negative bacterial infections Ceftolozane TFA can be used to synthesize new antibiotic that are more potent and safer[1
Apexbio Technology LLC BIBP 3226 trifluoroacetate(Synonyms: BIBP3226 TFA, BIBP3226 trifluoroacetate salt, NPY Y1 receptor antagonist BIBP3226), 2mg, CAS: 1068148-47-9.
BIBP 3226 trifluoroacetate (CAS 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors showing binding affinity with Ki values of 1 1 nM (rNPY Y1) 79 nM (hNPFF2) and 108 nM (rNPFF) BIBP 3226 competes with NPFF prevents NPFF-induced inhibition of forskolin-stimulated cAMP production and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety analgesia and cardiovascular regulation
Medchemexpress LLC Ecallantide (DX-88) trifluoroacetate | 00-00-0 | 7053.81 g/mol (free base) | C305H442N88O91S8 · xC2HF3O2 | 5 MG
Ecallantide TFA is a recombinant plasma kallikrein inhibitor supplied as the trifluoroacetate salt for research use. It inhibits kallikrein-mediated formation of bradykinin and is used in laboratory studies of angioedema and bradykinin-related pathways. Provided in defined small-scale packages for analytical and preclinical research; not for human use.
- Specific recombinant plasma kallikrein inhibitor.
- Trifluoroacetate salt formulation for stability and handling.
- Available in small, defined package sizes suitable for research.
- Characterized molecular weight and molecular formula provided.
- Intended for research use only; not for clinical or human use.
- Applicable to studies of bradykinin-mediated signaling and angioedema models.