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Filtered Search Results
Medchemexpress LLC Heptaminol hydrochloride | 543-15-7 | 98.0% | 500 MG
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Heptaminol hydrochloride is a vasoconstrictor primarily used in research concerning hypotension, including orthostatic hypotension. It also demonstrates potential as a skin cancer proliferation inhibitor and acts as a sympathomimetic amine.
- Used in hypotension studies.
- Inhibits skin cancer proliferation by reducing immune inflammation.
- Acts as a sympathomimetic amine with indirect sympathetic effects.
- Antagonizes catecholamine release and uptake.
- Increases intracellular free calcium levels.
- Solid appearance.
- White to off-white color.
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Medchemexpress LLC Isoxsuprine hydrochloride | 579-56-6 | 99.95% | 1 ML
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Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist and an NMDA receptor antagonist. It inhibits circular chemorepellent induced defect (CCID) formation and 12(S)-HETE synthesis, and can reduce infarct volume.
- Beta-adrenergic receptor agonist
- NMDA receptor antagonist
- Inhibits circular chemorepellent induced defect (CCID) formation
- Inhibits 12(S)-HETE synthesis
- Reduces infarct volume in vivo
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Medchemexpress LLC Mk-571 sodium | 115103-85-0 | 99.8% | 537.07 | 25 MG
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Mk-571 sodium | 115103-85-0 | 99.8% | 537.07 | 25 MG
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eMolecules 59107-51-6 | 8-Chloro-naphthalen-1-ylamine | J & W PharmLab LLC | MFCD00465087 | 177.630 | C10H8ClN | 96.000 | Nc1cccc2cccc(Cl)c12 | 5g | 292816209
8-Chloro-naphthalen-1-ylamine | J & W PharmLab LLC | 59107-51-6 | MFCD00465087 | 177.630 | C10H8ClN | 96.000 | Nc1cccc2cccc(Cl)c12 | 5g | 292816209
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Medchemexpress LLC Danegaptide Hydrochloride | 943133-81-1 | 99.5% | 327.76 | 25 MG
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Danegaptide Hydrochloride is a potent, selective, and orally active gap-junction modifier that exhibits an antiarrhythmic effect. It is intended for research use only. In vitro studies show it reduces dye uptake in cultured C6 glioma cells in a dose-dependent manner. In vivo, it prolongs the time to conduction block after CaCl2 infusion in mice and reduces atrial fibrillation in a dog model without affecting heart rate or blood pressure. This compound is an effective antiarrhythmic in ischemia/reperfusion-induced arrhythmogenesis.
- Potent, selective, and orally active gap-junction modifier
- Exhibits antiarrhythmic effect
- Reduces dye uptake in C6 glioma cells
- Prolongs time to conduction block in mice
- Reduces atrial fibrillation in dogs
- No effect on heart rate, arterial blood pressure, or ECG parameters
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TARGETMOL CHEMICALS INC BLU-945 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. BLU-945 is a potent highly selective reversible and orally active inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC). purity: 99%
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Medchemexpress LLC Mocravimod hydrochloride (KRP-203) | 509088-69-1 | 99.99% | 480.45 | 1 MG
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Mocravimod hydrochloride (KRP-203) | 509088-69-1 | 99.99% | 480.45 | 1 MG
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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 5 MG
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BI 3231 is a potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor. It has potential for research into nonalcoholic steatohepatitis (NASH) and other liver diseases.
- Potent and selective HSD17B13 inhibitor
- IC50s of 1 nM for hHSD17B13 and 13 nM for mHSD17B13
- Potential for research into nonalcoholic steatohepatitis (NASH)
- Useful for other liver diseases research
- Demonstrates high metabolic stability in liver microsomes
- Moderate metabolic stability in hepatocytes
- Considerable hepatic exposure maintained over 48 hours
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Medchemexpress LLC Pramocaine hydrochloride | 637-58-1 | 99.7% | 1 ML
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Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. It is for research use only and not sold to patients.
- Molecular weight: 329.86
- Chemical formula: C17H28ClNO3
- Appearance: solid
- Color: white to off-white
- Purity: 99.74%
- CAS number: 637-58-1
- Shipping: room temperature in continental US
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
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Medchemexpress LLC Loperamide hydrochloride | 34552-83-5 | 99.8% | 100 MG
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Loperamide hydrochloride is an opioid receptor agonist and a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. It has an anti-diarrheal effect and can also induce hallmarks of ER stress and autophagy in GBM cells and MEFs.
- Opioid receptor agonist
- Selective and competitive human intestinal carboxylesterases (hiCE) inhibitor
- Anti-diarrheal effect
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Ambeed AMBEED
5000848200 6-METHOXY-2-NAPHTHOIC A 5G
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Medchemexpress LLC Vabicaserin hydrochloride | 887258-94-8 | 99.5% | 264.79 | 50 MG
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Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM.
- Displaces 125I-(2,5-dimethoxy)phenylisopropylamine binding from human 5-HT2C receptor sites.
- Ki value of 3 nM and >50-fold selective over serotonergic, noradrenergic, and dopaminergic receptors.
- Potent and full agonist in stimulating 5-HT2C receptor-coupled calcium mobilization.
- Exhibits 5-HT2A receptor antagonism.
- Exhibits 5-HT2B antagonist or partial agonist activity in transfected cells.
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Medchemexpress LLC Revaprazan hydrochloride | 178307-42-1 | 100 MG
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Revaprazan hydrochloride is a reversible proton pump inhibitor that effectively inhibits gastric acid secretion and offers protection to the gastric mucosa. It functions by attenuating H. pylori-induced COX-2 expression through the inhibition of IκB-alpha degradation and Akt inactivation. This compound is suitable for research on infections and inflammation, including H. pylori-infected gastric inflammation and gastric ulcers.
- Reversibly inhibits proton pumps, reducing gastric acid secretion.
- Helps protect the stomach lining.
- Attenuates H. pylori-induced COX-2 expression.
- Achieves its effects by inhibiting IκB-alpha degradation and Akt inactivation.
- Useful for studies on various infections and inflammation, such as H. pylori-infected gastric inflammation and gastric ulcers.
- Available with a purity of 99.98%.
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Medchemexpress LLC Epirubicin hydrochloride (Standard) | 56390-09-1 | 99.9% | 579.98 | 25 MG
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Epirubicin hydrochloride (Standard) is an analytical standard intended for research and analytical applications. It is a semisynthetic L-arabino derivative of doxorubicin, acting as an antineoplastic agent. This compound inhibits Topoisomerase, DNA, and RNA synthesis, and also functions as a Forkhead box protein p3 (Foxp3) inhibitor.
- Analytical standard for research and analytical applications
- Semisynthetic L-arabino derivative of doxorubicin
- Antineoplastic agent
- Inhibits Topoisomerase
- Inhibits DNA and RNA synthesis
- Foxp3 inhibitor, inhibiting regulatory T cell activity
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
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Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mg, CAS: 755038-02-9.
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BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
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