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Filtered Search Results
AdipoGen trans-Methyl-2-dodecenoic acid
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Chemical. CAS 677354-24-4. Formula C13H24O2. MW 212.3. Synthetic. trans-Delta2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Delta2-11-methyl-dodecenoic acid, a diffusible signal factor DSF in extracellular microbial and fungal communication systems. Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. In a DSF bioassay, the minimum concentration of cis-Delta2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Delta2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid 11-methyl-dodecanoic acid.
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AdipoGen trans-Methyl-2-dodecenoic acid
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Chemical. CAS 677354-24-4. Formula C13H24O2. MW 212.3. Synthetic. trans-Delta2-11-methyl-Dodecenoic acid is the conformational isomer of cis-Delta2-11-methyl-dodecenoic acid, a diffusible signal factor DSF in extracellular microbial and fungal communication systems. Both prokaryotes and eukaryotes depend on small signalling molecules for cell-cell communication. In a DSF bioassay, the minimum concentration of cis-Delta2-11-methyl-dodecenoic acid required for induction of a DSF biosensor was about 0.5 µM, which is 200-fold lower than that of trans-Delta2-11-methyl-dodecenoic acid and 20,000-fold lower than that of the corresponding saturated fatty acid 11-methyl-dodecanoic acid.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000784183 NAPHTHALENE-1 4-DICA 25G
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TARGETMOL CHEMICALS INC BI-2493 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865. purity: 99%
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Medchemexpress LLC (R)-V-0219 hydrochloride | C20H26ClF3N4O2 | 100 MG
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(R)-V-0219 hydrochloride is an enantiomer of V-0219, functioning as an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). It is noted for activating calcium fluxes in HEK cells stably expressing hGLP-1R.
- Induces receptor activation stimulated by GLP-1 with an EC50 value of 10 nM.
- Activates calcium fluxes in HEK cells stably expressing hGLP-1R.
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Medchemexpress LLC Dipivefrin hydrochloride | 64019-93-8 | 98.4% | 100 MG
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Dipivefrin hydrochloride is an antiglaucoma proagent that is hydrolyzed by esterases in the cornea to its active compound, epinephrine. It is for research use only and not sold to patients.
- Antiglaucoma proagent
- Hydrolyzed to active epinephrine by corneal esterases
- Induces enhancement of memory involving central beta-adrenergic mechanisms in male 60-day-old CFW mice (0.3-10 μg/kg; i.p.), significantly enhancing retention of inhibitory avoidance and Y-maze discrimination tasks in a dose-dependent manner.
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TARGETMOL CHEMICALS INC ALPHA-MSH 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. (alpha)-MSH (MSH amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. purity: 100%
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TARGETMOL CHEMICALS INC BI-1347 10MG
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BI-1347 is a potent selective inhibitor of CDK8/cyclinC (IC50 1 nM). It shows tumor growth inhibition in an in vivo xenograft model. purity: 99%
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Medchemexpress LLC Ald-Ph-amido-C2-PEG3-azide | 1807540-88-0 | 25 MG
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Ald-Ph-amido-C2-PEG3-azide is a laboratory chemical used for the manufacture of substances and is for research use only. It is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This click chemistry reagent contains an azide group, enabling copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Contains an azide group for click chemistry reactions.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc).
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Exploits the intracellular ubiquitin-proteasome system to degrade target proteins.
- For research use only.
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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 10mg, CAS: 1869912-39-9.
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AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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Medchemexpress LLC Amantadine hydrochloride | 665-66-7 | 98.0% | 10 G
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Amantadine hydrochloride is an orally active and potent antiviral agent effective against influenza A viruses. It inhibits various ion channels, including NMDA and M2, and also targets Coronavirus ion channels. This compound also demonstrates anti-orthopoxvirus and anticancer activities, making it suitable for research in Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19.
- Inhibits SARS-CoV-2 replication
- Inhibits proliferation of HepG2 and SMMC-7721 cells
- Arrests cell cycle at G0/G1 phase and induces apoptosis
- Reduces levels of cell cycle-related genes and proteins
- Reduces Bcl-2 and increases Bax protein and mRNA levels
- Inhibits surgery-induced neuroinflammation and learning and memory impairment
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AdipoGen 5-Aminonicotinic acid
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Chemical. CAS 24242-19-1. Formula C6H6N2O2. MW 138.12. Synthetic. Building block for synthesis. Used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents.
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Medchemexpress LLC 1-naphthalenesulfonic acid, 3,4-dihydro-3,4-dioxo-, potassium salt | 5908-27-0 | MFCD00001699 | 99.8% | 276.31 | C10H5KO5S | 1g
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Potassium 1 2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC50 of 53 M Potassium 1 2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis[1]
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eMolecules 1141-38-4 | Naphthalene-2,6-dicarboxylic acid | ChemScene | MFCD00004105 | 216.192 | C12H8O4 | 97.000 | OC(=O)c1ccc2cc(ccc2c1)C(O)=O | 500g | 801475668
Naphthalene-2,6-dicarboxylic acid | ChemScene | 1141-38-4 | MFCD00004105 | 216.192 | C12H8O4 | 97.000 | OC(=O)c1ccc2cc(ccc2c1)C(O)=O | 500g | 801475668
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Medchemexpress LLC (E)-4-(Naphthalen-2-yl)but-3-en-2-one | 51557-10-9 | 99.9% | 196.24 | 250 MG
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(E)-4-(Naphthalen-2-yl)but-3-en-2-one is a small active molecule that can be used as a building block. It exhibits anti-leukemic activity, inhibiting the proliferation of human chronic myeloid leukemia cell K562 with an IC50 of 7.6 μM.
- Can be used as a building block.
- Exhibits anti-leukemic activity.
- Inhibits the proliferation of human chronic myeloid leukemia cell K562.
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