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Filtered Search Results
Medchemexpress LLC Fedratinib (hydrochloride hydrate) | 1374744-69-0 | 99.9% | 615.62 | 1 G
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Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive, and orally active inhibitor of JAK2. It exhibits an IC50 of 3 nM for both JAK2 and JAK2V617F kinase and demonstrates significant selectivity over JAK1 (35-fold) and JAK3 (334-fold). This compound has been shown to induce apoptosis in cancer cells and is considered to have potential for research in myeloproliferative disorders.
- Potent, selective, ATP-competitive, and orally active JAK2 inhibitor.
- Targets both JAK2 and JAK2V617F kinase effectively at 3 nM IC50.
- Exhibits high selectivity against JAK1 (35-fold) and JAK3 (334-fold).
- Induces apoptosis in cancer cells.
- Shows promise for research in myeloproliferative disorders.
- Inhibits proliferation of cell lines carrying the JAK2V617F mutation.
- Reduces STAT5 phosphorylation.
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Medchemexpress LLC Paroxetine (hydrochloride) | 78246-49-8 | 100.0% | 1 ML
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Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor and a GRK2 inhibitor with an IC50 of 14 μM. It is used in research for depressive disorders and other biological activities.
- Potent selective serotonin-reuptake inhibitor
- GRK2 inhibitor with an IC50 of 14 μM
- Used for research of depressive disorder
- Restrains T cell migration induced by CX3CL1
- Inhibits GRK2 induced activation of ERK
- Reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells
- Inhibits LPS-induced nitric oxide production and iNOS expression in BV2 cells
- Blocks LPS-induced JNK activation
- Attenuates symptoms of CIA rats and prevents histological damage of joints
- Reduces myocyte cross-sectional area in rats and ROS formation
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Medchemexpress LLC Adriforant hydrochloride (PF-3893787 hydrochloride) | 2096455-90-0 | 98.0% | 371.74 | 1 ML
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Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor antagonist with a binding affinity (Ki) of 2.4 nM and is also a functional (Ki) antagonist at 1.56 nM. It is suitable for laboratory research and studies involving histamine receptors.
- Novel histamine H4 receptor antagonist
- High binding affinity and functional antagonism
- Suitable for high-speed applications
- Leak-resistant cap for secure storage
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Cayman Chemical Naphthol AS-BI-Phosphate 500mg
A fluorogenic substrate for acid and alkaline phosphatases; is converted to N-ASBI which displays ex/em spectra of 405/515 nm, respectively; fluorescence is a quantitative marker of acid and alkaline phosphatase activity
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![eMolecules 75724-98-0 | 2,3,5,6-Tetramethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311498 | 237.423 | C10H13BrMg | 0.000 | [Br-].Cc1cc(C)c(C)c([Mg+])c1C | 25ml | 437237444](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697497.jpg-250.jpg)
eMolecules 75724-98-0 | 2,3,5,6-Tetramethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311498 | 237.423 | C10H13BrMg | 0.000 | [Br-].Cc1cc(C)c(C)c([Mg+])c1C | 25ml | 437237444
2,3,5,6-Tetramethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 75724-98-0 | MFCD01311498 | 237.423 | C10H13BrMg | 0.000 | [Br-].Cc1cc(C)c(C)c([Mg+])c1C | 25ml | 437237444
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![eMolecules 82214-69-5 | 2-Biphenylmagnesium bromide, 0.5 M in 2-MeTHF | Synthonix - Stock | MFCD01311477 | 257.413 | C12H9BrMg | 0.000 | [Br-].[Mg+]c1ccccc1-c1ccccc1 | 50ml | 437236962](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697773.jpg-250.jpg)
eMolecules 82214-69-5 | 2-Biphenylmagnesium bromide, 0.5 M in 2-MeTHF | Synthonix - Stock | MFCD01311477 | 257.413 | C12H9BrMg | 0.000 | [Br-].[Mg+]c1ccccc1-c1ccccc1 | 50ml | 437236962
2-Biphenylmagnesium bromide, 0.5 M in 2-MeTHF | Synthonix - Stock | 82214-69-5 | MFCD01311477 | 257.413 | C12H9BrMg | 0.000 | [Br-].[Mg+]c1ccccc1-c1ccccc1 | 50ml | 437236962
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![eMolecules 17680-04-5 | 1,3-Benzodioxol-5-ylmagnesium bromide, 0.5 M in THF | Synthonix - Stock225.324 | C7H5BrMgO2 | 0.000 | [Br-].[Mg+]c1ccc2OCOc2c1 | 500ml | 437236953](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697782.jpg-250.jpg)
eMolecules 17680-04-5 | 1,3-Benzodioxol-5-ylmagnesium bromide, 0.5 M in THF | Synthonix - Stock225.324 | C7H5BrMgO2 | 0.000 | [Br-].[Mg+]c1ccc2OCOc2c1 | 500ml | 437236953
1,3-Benzodioxol-5-ylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 17680-04-5225.324 | C7H5BrMgO2 | 0.000 | [Br-].[Mg+]c1ccc2OCOc2c1 | 500ml | 437236953
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eMolecules 4319-49-7 | N-Aminomorpholine | AbaChemScene | MFCD00006174 | 102.137 | C4H10N2O | 95.000 | NN1CCOCC1 | 10g | 391088266
N-Aminomorpholine | AbaChemScene | 4319-49-7 | MFCD00006174 | 102.137 | C4H10N2O | 95.000 | NN1CCOCC1 | 10g | 391088266
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![eMolecules 312692-96-9 | 2,5-Dimethylphenylzinc iodide, 0.50 M in THF | Synthonix297.440 | C8H9IZn | 0.000 | [I-].Cc1ccc(C)c([Zn+])c1 | 50ml | 532652760](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696228.jpg-250.jpg)
eMolecules 312692-96-9 | 2,5-Dimethylphenylzinc iodide, 0.50 M in THF | Synthonix297.440 | C8H9IZn | 0.000 | [I-].Cc1ccc(C)c([Zn+])c1 | 50ml | 532652760
2,5-Dimethylphenylzinc iodide, 0.50 M in THF | Synthonix | 312692-96-9297.440 | C8H9IZn | 0.000 | [I-].Cc1ccc(C)c([Zn+])c1 | 50ml | 532652760
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![eMolecules Synthonix 1-Ethyl-3-methylimidazolium Acetate 100g 831794392 E38121 143314-17-4 [null] 170.212 C8H14N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694304.jpg-250.jpg)
eMolecules Synthonix 1-Ethyl-3-methylimidazolium Acetate 100g 831794392 E38121 143314-17-4 [null] 170.212 C8H14N2O2
Synthonix 1-Ethyl-3-methylimidazolium Acetate 100g 831794392 E38121 143314-17-4 [null] 170.212 C8H14N2O2
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Medchemexpress LLC Aceclidine hydrochloride | 6109-70-2 | 98.0% | 205.68 | 1 ML
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Aceclidine hydrochloride is a modulator of the M3 muscarinic acetylcholine receptor and acts as an M1 receptor agonist with an EC50 of 40 μM. It functions as a cycloplegic agent, a surfactant, a tonicity adjustor, and can optionally serve as a viscosity enhancer and an antioxidant. This compound holds potential for research into various disorders, including refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia.
- Modulator of M3 muscarinic acetylcholine receptor.
- M1 receptor agonist (EC50: 40 μM).
- Functions as a cycloplegic agent.
- Acts as a surfactant.
- Serves as a tonicity adjustor.
- Can optionally be a viscosity enhancer and an antioxidant.
- Potential for research in disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia.
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Medchemexpress LLC Guvacoline hydrochloride | 6197-39-3 | 25 MG
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Guvacoline hydrochloride is a pyridine alkaloid found in Areca triandra that acts as a weak full agonist of atrial and ileal muscarinic receptors.
- Pyridine alkaloid
- Found in Areca triandra
- Acts as a weak full agonist of atrial and ileal muscarinic receptors
- Purity: 98.0%
- Appearance: solid
- Color: white to off-white
- Molecular weight: 177.63
- Molecular formula: C7H12ClNO2
- Storage: 4°C, sealed, away from moisture and light
- Soluble in H2O: 100 mg/mL (needs ultrasonic)
- Soluble in DMSO: 100 mg/mL (needs ultrasonic)
- For research use only
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Medchemexpress LLC Alizapride hydrochloride | 59338-87-3 | 99.8% | C16H22ClN5O2 | 1 ML
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Alizapride is a potent antiemetic that functions as a dopamine receptor antagonist. It is also utilized in the treatment of human digestive disorders.
- Potent antiemetic properties
- Functions as a dopamine receptor antagonist
- Useful in treating human digestive disorders
- Significantly reduces bound IgG-sensitized erythrocytes with splenic macrophages
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Medchemexpress LLC Diphenidol hydrochloride | 3254-89-5 | 99.1% | C21H28ClNO | 500 MG
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Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist with anti-arrhythmic activity. It also acts as a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. This compound can be utilized in the study of antivertigo and antinausea.
- Non-selective muscarinic M1-M4 receptor antagonist
- Possesses anti-arrhythmic activity
- Potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells
- Useful in the study of antivertigo and antinausea
- Inhibits sodium currents and produces spinal anesthesia in N2A cells
- Reduces neuropathic pain and TNF-α overexpression in rats
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Medchemexpress LLC Tamsulosin (hydrochloride) | 106463-17-6 | 99.8% | 25 MG
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Tamsulosin hydrochloride is an orally active antagonist of the α1-adrenergic receptor. It induces apoptosis and is used for research related to prostatic hyperplasia. It also attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.
- Orally active α1-adrenergic receptor antagonist
- Induces apoptosis
- Used for research of prostatic hyperplasia
- Attenuates abdominal aortic aneurysm growth
- Inhibits inflammation in animal models
- Stable under recommended storage conditions
- White to off-white solid appearance
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