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Filtered Search Results
Medchemexpress LLC BI 99179 | 1291779-76-4 | 99.38% | 391.46 | 5 MG
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BI 99179 is a chemical probe that acts as a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. It is a tool compound suitable for in vivo validation of FAS as a target for lipid metabolism-related diseases and shows significant peripheral and central exposure upon oral administration in rats.
- Potent in mouse hypothalamic N-42 cells with an IC50 of 0.6 μM.
- No significant LDH release in cytotoxicity assays up to 30 μM.
- Exhibits antiproliferative efficacy in human glioma GAMG cells.
- Possesses a super pharmacokinetic profile in male Han/Wistar rats.
- For research use only.
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Medchemexpress LLC Valnemulin hydrochloride | 133868-46-9 | 98.1% | C31H53ClN2O5S | 100 MG
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Valnemulin hydrochloride is an orally effective truncated pleurotin antibiotic that inhibits protein synthesis in bacteria by binding to peptidyl transferase in the 50s ribosome subunit.
- Effective in eliminating Mycobacterium bovis from the lungs in experimental bovine models.
- Reduces mortality associated with epidemic rabbit enteropathy without adversely affecting growth performance.
- Controls experimental infection in calves, diminishing clinical signs, restoring appetite, and reversing weight loss.
- Reduces the isolation of Pasteurella multocida from infected calves' lungs.
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Medchemexpress LLC Givinostat hydrochloride monohydrate | 732302-99-7 | 99.6% | 475.97 | 25 MG
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Givinostat hydrochloride monohydrate is a potent HDAC inhibitor, demonstrating IC50 values of 198 nM for HDAC1 and 157 nM for HDAC3. This compound is notable for its ability to penetrate the blood-brain barrier, making it suitable for a range of research applications.
- Potent HDAC inhibitor for HDAC1 and HDAC3
- Penetrates the blood-brain barrier
- Suppresses LPS-induced IL-1β and IL-6 production
- Inhibits JS-1 cell proliferation
- Reduces serum TNFα and IL-1β levels in vivo
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Aobchem AOBCHEM
5000865529 6-BROMO-1-CHLORO-2-NAPHTHOL 50
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(CCCC)c1cccnc1OC | 1g | 525920394](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502447272.PNG-250.jpg)
eMolecules 223418-74-4 | 2-Methoxy-3-(tributylstannyl)pyridine | Synthonix - Stock | MFCD01319029 | 398.178 | C18H33NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1OC | 1g | 525920394
2-Methoxy-3-(tributylstannyl)pyridine | Synthonix - Stock | 223418-74-4 | MFCD01319029 | 398.178 | C18H33NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1cccnc1OC | 1g | 525920394
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eMolecules 1823378-45-5 | ChemScene | Methyl 6-chloro-5-fluoropyrazine-2-carboxylate | 100mg | 632307520 | CS-0162704 | 190.56 | C6H4ClFN2O2
Ambeed | (4R4R)-22-(Pentane-33-diyl)bis(4-methyl-45-dihydrooxazole) | 100mg | 633659969 | A1258393 | 2828432-10-4 | 238.331 | C13H22N2O2
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Apexbio Technology LLC Linagliptin (BI-1356) 668270-12-0 10mg
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Linagliptin (BI-1356 CAS 668270-12-0) is a potent competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) demonstrating IC50 values of 0 4 1 1 nM in multiple in vitro assays using DPP-4 extracted from Caco-2 cells DPP-4 is a membrane-bound and soluble protease involved in the degradation of incretin hormones such as GLP-1 which enhance pancreatic -cell glucose sensitivity and insulin secretion Linagliptin displays marked selectivity for DPP-4 over related peptidases and serine proteases In vivo linagliptin dose-dependently inhibits plasma DPP-4 activity and sustains glycemic control with prolonged effects observed at pharmacologically relevant doses This compound is widely utilized in studies of glucose metabolism and -cell function
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431596 BI-27 SUPPLEMENT 50 10ML
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Medchemexpress LLC NSC 146109 hydrochloride | 59474-01-0 | MFCD09878281 | 99.9% | 316.85 | 100 MG
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NSC 146109 hydrochloride is a small-molecule p53 activator that targets MDMX and is suitable for breast cancer research. As a pseudourea derivative, it functions by activating p53 and inducing the expression of proapoptotic genes, thereby promoting apoptosis in breast cancer cells.
- Activates p53
- Targets MDMX
- Induces expression of proapoptotic genes
- Promotes apoptosis in breast cancer cells
- Pseudourea derivative
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eMolecules 136834-22-5 | ChemScene | DMT-2fluoro-da(bz) amidite | 250mg | 536833179 | CS-B1581 | 875.939 | C47H51FN7O7P
Ambeed | 7-(Trifluoromethyl)-1H-indole-2-carboxylic acid | 100mg | 491665372 | A404354 | 172216-98-7 | MFCD02664424 | 229.158 | C10H6F3NO2
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Medchemexpress LLC Epinastine hydrochloride | 108929-04-0 | 99.9% | 1 ML
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Epinastine hydrochloride | 108929-04-0 | 99.9% | 1 ML
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Apexbio Technology LLC MK-571 sodium salt hydrate 115103-85-0 50mg
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MK-571 sodium salt hydrate (CAS 115103-85-0) is an antagonist of the cysteinyl-leukotriene type 1 receptor (CysLT1) a cell-surface receptor mediating allergic and hypersensitivity responses via cysteinyl leukotrienes In addition MK-571 acts as an inhibitor of multidrug resistance-associated protein 2 (ABCC2/Mrp2) commonly employed in vitro to investigate Mrp2-mediated efflux of xenobiotics and conjugates in epithelial cells Experimental evidence with Caco-2/TC7 cells indicates MK-571 also inhibits phase-2 conjugation of flavonols interfering competitively with glucuronide formation Its utilization thus spans immune-related receptor signaling studies and characterizing cellular drug transport mechanisms
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Apexbio Technology LLC AZD 5153(Synonyms: AZD5153, AZD-5153, AZD 5153 dihydrochloride, BRD4 inhibitor AZD5153, AZD5153 BRD4 inhibitor), 25mg, CAS: 1869912-39-9.
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AZD5153 (CAS 1869912-39-9) is a potent selective orally bioavailable inhibitor of the bromodomain and extraterminal (BET) family protein BRD4 Through simultaneous binding of both bromodomains in BRD4 AZD5153 effectively disrupts BRD4-mediated transcriptional regulation In cellular assays AZD5153 demonstrates high activity notably displacing BRD4 with an IC50 of approximately 1 7 nM in U2OS cells It significantly inhibits growth of AML multiple myeloma and diffuse large B-cell lymphoma cell lines reducing mTOR pathway signaling In vivo AZD5153 shows dose-dependent antitumor efficacy in xenograft models of hematologic malignancies indicating its value as a tool compound in cancer research
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Medchemexpress LLC Teslexivir hydrochloride | 1075281-70-7 | 98.28% | 679.04 | 25 MG
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Teslexivir hydrochloride is a potent antiviral agent. It is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2. This association is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research.
- Potent antiviral agent
- Selective inhibitor of E1 and E2 viral protein interaction
- Inhibits DNA replication and viral production for HPV 6 and 11
- Suitable for condyloma research
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Medchemexpress LLC CRA-026440 hydrochloride | 847459-98-7 | 98.1% | 456.92 | 100 MG
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CRA-026440 hydrochloride is a potent, broad-spectrum HDAC inhibitor. It shows antitumor and antiangiogenic activities. This compound is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, broad-spectrum HDAC inhibitor
- Shows antitumor and antiangiogenic activities
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
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