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Filtered Search Results
AdipoGen Fipronil
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Chemical. CAS 120068-37-3. Formula C12H4Cl2F6N4OS. MW 437.2. Alzheimer inducing agent Alzheimerogen. Potent GABA receptor alpha-4 subunit and beta-3 subunit inhibitor. Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels GluCls in the central nervous system, resulting in overexcitation of the insects nervous system and muscles. Induces oxidative stress in mouse kidney and brain. Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
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eMolecules 199465-66-2 | 2-Cyanobenzylzinc bromide, 0.50 M in THF | Synthonix | MFCD01311397 | 261.430 | C8H6BrNZn | 0.000 | [Br-].[Zn+]Cc1ccccc1C#N | 25ml | 627353551
2-Cyanobenzylzinc bromide, 0.50 M in THF | Synthonix | 199465-66-2 | MFCD01311397 | 261.430 | C8H6BrNZn | 0.000 | [Br-].[Zn+]Cc1ccccc1C#N | 25ml | 627353551
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eMolecules 166766-89-8 | 3-Methyl-2-(tributylstannyl)thiophene | Synthonix - Stock | MFCD09025807 | 387.210 | C17H32SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1sccc1C | 1g | 525920524
3-Methyl-2-(tributylstannyl)thiophene | Synthonix - Stock | 166766-89-8 | MFCD09025807 | 387.210 | C17H32SSn | 97.000 | CCCC[Sn](CCCC)(CCCC)c1sccc1C | 1g | 525920524
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AdipoGen Naphthol AS-BI phosphate
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Chemical. CAS 1919-91-1. Formula C18H15BrNO6P. MW BD9837. Naphthol AS-BI-phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-BI-phosphate is converted to naphthol AS-BI N-ASBI displaying excitation/emission spectra of 405/515nm. N-ASBI fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications.
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Medchemexpress LLC Amiodarone hydrochloride | 19702-44-2 | MFCD00079083 | C25H30ClI2NO3 | 100 MG
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Amiodarone hydrochloride is a class III antiarrhythmic agent used in the treatment of various ventricular and supraventricular arrhythmias. It works by prolonging the action potential and refractory period in myocardial tissue.
- Acts as an antagonist at α1, β1, and β2 adrenoceptors
- Functions as a non-competitive antagonist at muscarinic receptors
- Blocks cardiac K+ channels and L-type Ca2+ channels
- Displays anti-anginal, anti-fibrillatory, and vasodilator effects
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eMolecules 3669-52-1 | 4-acetyl-1-naphthol | MFCD00100999 | 5g
Ambeed | tert-Butyl 4-carbamoylbenzylcarbamate | 100mg | 600840941 | A461827 | 871721-44-7 | MFCD24389093 | 250.298 | C13H18N2O3
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eMolecules 110-71-4 | 1,2-Dimethoxyethane | Oakwood Chemicals | MFCD00008502 | 90.122 | C4H10O2 | 99.000 | COCCOC | 100ml | 480148964
1,2-Dimethoxyethane | Oakwood Chemicals | 110-71-4 | MFCD00008502 | 90.122 | C4H10O2 | 99.000 | COCCOC | 100ml | 480148964
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eMolecules 312693-21-3 | 4-Methylbenzylzinc chloride, 0.50 M in THF | Synthonix | MFCD01319888 | 205.990 | C8H9ClZn | 0.000 | [Cl-].Cc1ccc(C[Zn+])cc1 | 50ml | 702445949
4-Methylbenzylzinc chloride, 0.50 M in THF | Synthonix | 312693-21-3 | MFCD01319888 | 205.990 | C8H9ClZn | 0.000 | [Cl-].Cc1ccc(C[Zn+])cc1 | 50ml | 702445949
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eMolecules 58207-97-9 | Tributyl[(1E)-2-(trimethylsilyl)ethenyl]stannane | Synthonix - Stock389.286 | C17H38SiSn | 97.000 | CCCC[Sn](CCCC)(CCCC)\C=C\[Si](C)(C)C | 500mg | 525932270
Tributyl[(1E)-2-(trimethylsilyl)ethenyl]stannane | Synthonix - Stock | 58207-97-9389.286 | C17H38SiSn | 97.000 | CCCC[Sn](CCCC)(CCCC)\C=C\[Si](C)(C)C | 500mg | 525932270
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eMolecules 1217737-76-2 | (S)-tert-Butyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | ChemScene | MFCD09955433 | 257.330 | C13H23NO4 | 97.000 | COC(=O)C[C@@H]1CCCN(C1)C(=O)OC(C)(C)C | 100mg | 687352817
(S)-tert-Butyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | ChemScene | 1217737-76-2 | MFCD09955433 | 257.330 | C13H23NO4 | 97.000 | COC(=O)C[C@@H]1CCCN(C1)C(=O)OC(C)(C)C | 100mg | 687352817
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Medchemexpress LLC Adrenalone (hydrochloride) | 62-13-5 | 99.9% | 100 MG
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Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. It is also an inhibitor of dopamine β oxidase and is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM. It is a topical nasal decongestant, hemostatic, and vasoconstrictor, and a keton form of the natural substrate epinephrine. Adrenalone hydrochloride inhibits the activity of dopamine β-oxidase and substrate transport by NET.
- Adrenergic agonist
- Topical vasoconstrictor and hemostatic
- Inhibitor of dopamine β oxidase
- Chemically similar to norepinephrine transporter (NET) ligands (IC50 of 36.9 μM)
- Topical nasal decongestant
- Keton form of natural substrate epinephrine
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Medchemexpress LLC Asimadoline hydrochloride | 185951-07-9 | 99.8% | 451.00 | C27H31ClN2O2 | 1 ML
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Asimadoline hydrochloride is the hydrochloride salt of asimadoline, a selective, peripherally active κ-opioid receptor agonist supplied for research use. It exhibits low blood-brain barrier permeability and has been investigated for peripheral analgesic and antinociceptive effects, including potential utility in visceral pain and irritable bowel syndrome.
- Selective κ-opioid receptor agonist activity with low-nanomolar potency.
- Peripherally restricted compound with low central nervous system penetration.
- High chemical purity (99.82%).
- Molecular weight 451.00 g/mol.
- Available as 10 mM solution in DMSO and in solid quantities for formulation.
- Intended for research use only; not for human or clinical use.
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Medchemexpress LLC 2-(3,5-difluoro-4-hydroxyphenylamino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one | 501437-28-1 | MFCD11223662 | >98.0% | 391.42 g·mol⁻¹ | C19H23F2N5O2 | 500 MG
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BI-D1870 is a potent, ATP-competitive inhibitor of the p90 ribosomal S6 kinase (RSK) family. It is cell permeable and reported to penetrate the brain, making it suitable for cellular and in vivo studies of RSK-mediated signaling and related biological processes.
- Selective ATP-competitive inhibitor of RSK isoforms.
- Low nanomolar potency against RSK1-RSK4 (IC50s: 31, 24, 18, 15 nM).
- Cell permeable for use in cellular assays.
- Reported brain penetration supports in vivo applications.
- Useful for studying MAPK/ERK-RSK signaling pathways.
- Available as a solid suitable for storage and formulation.
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Medchemexpress LLC (2S)-3-[3-[[3-cyano-4-(difluoromethyl)-6-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]pyridin-2-yl]amino | 3043939-18-7 | 97.8% | 489.58 g/mol | C24H29F2N5O2S | 10 MG
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BI-9787 is a potent, zwitterionic ketohexokinase (KHK) inhibitor provided for research use. It exhibits low-nanomolar potency against human KHK isoforms, shows good metabolic stability, and has been characterized in preclinical pharmacokinetic studies.
- Potent KHK inhibitor with reported IC50 values of 12 nM (hKHK-A) and 12.8 nM (hKHK-C).
- Zwitterionic structure supporting permeability and oral exposure in preclinical models.
- Demonstrated metabolic stability and favorable pharmacokinetic properties in rat studies.
- High chemical purity (~97.8%) suitable for research applications.
- Molecular weight 489.58 g/mol; formula C24H29F2N5O2S.
- Available in small pack sizes for dosing and in vivo work.
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Medchemexpress LLC Acoramidis hydrochloride | 2242751-53-5 | 98.7% | 328.77 | 1 MG
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Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of both wild-type (WT) and V122I-TTR (transthyretin). It is utilized in studies related to transthyretin amyloidosis.
- Orally active.
- Selective kinetic stabilizer of WT and V122I-TTR.
- Stabilizes V122I- and WT-TTR equally well and exceeds tafamidis in stabilizing WT and mutant TTR in whole serum at concentrations between 0.1-10 μM.
- Stimulates mitochondrial QO2 in a concentration-dependent manner between 10 and 100 μM.
- Exhibits minimal inhibition of common off-targets, such as the potassium ion channel hERG (IC50 > 100 μM) and cytochrome P450 isozymes (IC50 > 50 μM), indicating low toxicity.
- In Wistar rats, an oral gavage of 50 mg/kg/d for 28 days showed a plasma Cmax of ~40 μM with no pathological processes in liver, kidney, heart, spleen, thymus, and lung.
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