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Filtered Search Results
Selleck Chemical LLC ETC-159
ETC-159 (ETC-1922159) is an orally available potent porcupine inhibitor with an IC50 of 2 9 nM for inhibiting -catenin reporter activity in STF3A cells
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![Medchemexpress LLC Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl- | 1513879-21-4 | 99.9% | 352.39 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386064-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl- | 1513879-21-4 | 99.9% | 352.39 | 100 MG
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BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 nM for human PI4KIIIβ and 3.5 nM for the Plasmodium variant of PI4KIIIβ. Treatment with 0.5 μM causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. This inhibitor shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest, and exhibits cross-resistance with imidazopyrazine-resistant lines.
- Potent PI4KIIIβ inhibitor
- Effective against human and Plasmodium PI4KIIIβ variants
- Induces schizont-stage arrest
- No toxicity against mature red blood cells
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Medchemexpress LLC Dichlorobis(tricyclohexylphosphine)palladium(II) | 29934-17-6 | MFCD00191830 | 98.0% | 738.2 g/mol | C36H66Cl2P2Pd | 5 G
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Dichlorobis(tricyclohexylphosphine)palladium(II) is a palladium(II) phosphine complex used as a homogeneous catalyst in organic synthesis. It is commonly employed for C-C and C-N cross-coupling reactions and for the carbonylation of chloroarenes under mild conditions, and is supplied as a solid for research use.
- Used as a homogeneous catalyst for C-C and C-N cross-coupling reactions.
- Effective in the carbonylation of chloroarenes under mild conditions.
- High purity suitable for research applications.
- Solid form for straightforward handling and storage.
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Chemscene CHEMSCENE
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5000575524 TRICYCLO 8 2 2 24 7 HEXADE 25G
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Chemscene CHEMSCENE
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5000576903 TRICYCLO 8 2 2 24 7 HEXAD 500G
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Strem, An Ascensus Company TRANS-DICHLOROBIS/TRICYCLO-5G
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NC3734888 TRANS-DICHLOROBIS/TRICYCLO-5G
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Medchemexpress LLC ETC-159 | 1638250-96-0 | 99.13% | 391.38 | 50 MG
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ETC-159 | 1638250-96-0 | 99.13% | 391.38 | 50 MG
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Sigma Aldrich Fine Chemicals Biosciences Allylcyclopentane 97% | 3524-75-2 | MFCD00001390 | 25G
Allylcyclopentane 97% | Purity: 97% | Mol Wt: 110.2 | 3524-75-2 | MFCD00001390 | 25G
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Medchemexpress LLC ETC-159 | 1638250-96-0 | 99.1% | 391.38 | 1 ML
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ETC-159 is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM. It is intended for research use only.
- Inhibits β-catenin reporter activity
- Potent and orally available PORCN inhibitor
- Active in multiple cancer models with high Wnt signaling
- Efficacious in colorectal cancers with R-spondin translocations
- Good oral pharmacokinetics in mice with 100% oral bioavailability
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Medchemexpress LLC BQR-695 | 1513879-21-4 | 99.9% | 352.39 | 1 ML
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BQR-695 is a PI4KIIIβ inhibitor effective against both human and Plasmodium variant PI4KIIIβ. This compound is for research use only, shows no toxicity to mature red blood cells, and induces a schizont-stage arrest.
- Has an IC50 of 80 nM for human PI4KIIIβ.
- Has an IC50 of 3.5 nM for the Plasmodium variant of PI4KIIIβ.
- Induces schizont-stage arrest.
- Exhibits cross-resistance with imidazopyrazine-resistant lines.
- Causes GFP-PHOsh2 redistribution to the parasite plasma membrane, indicating PI4P depletion.
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Medchemexpress LLC N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) | 74267-27-9 | 99.4% | 460.69 | 25 MG
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N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrodes. Calcium ion-selective electrodes can be used to measure intracellular free calcium.
- Lipophilic ionophore
- Used in preparing calcium ion-selective electrodes
- Enables measurement of intracellular free calcium
- For research use only
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Medchemexpress LLC N-(1-((3-(4-(dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1 | 2741262-15-5 | 98.8% | 685.02 g/mol | C28H32Cl3N7O5S | 10 MG
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Small-molecule inhibitor of cyclin-dependent kinases CDK14 and CDK16 for biochemical and cell-based research. It demonstrates potent inhibition with reported IC50 values of 5.9 nM (CDK14) and 139.1 nM (CDK16). The compound is supplied as a purified solid suitable for laboratory use.
- Potent inhibition of CDK14 and CDK16 with reported IC50s of 5.9 nM and 139.1 nM.
- High purity (98.8% by HPLC).
- Well-characterized physicochemical properties, molecular weight 685.02 g/mol.
- Supplied as a solid suitable for low-temperature storage.
- Available in milligram quantities for research use (10 MG).
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Sigma Aldrich Fine Chemicals Biosciences Allylcyclohexane | 2114-42-3 | MFCD00013769 | 25g
Allylcyclohexane | Purity: 96% | Mol Wt: 124.22 | 2114-42-3 | MFCD00013769 | 25g
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Medchemexpress LLC 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide | 1638250-96-0 | MFCD29472267 | ≥95.0% | 391.4 | C19H17N7O3 | 10 MG
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ETC-159 is a potent, orally available porcupine (PORCN) inhibitor used in research to block Wnt ligand secretion and Wnt/β-catenin signaling. It inhibits β-catenin reporter activity with a reported IC50 of 2.9 nM and has been evaluated in preclinical and early clinical studies for Wnt-dependent cancers. Typical supplier purity is ≥95% and the compound is supplied as a crystalline solid.
- Potent PORCN inhibition with low nanomolar activity.
- Orally bioavailable for in vivo research applications.
- Blocks Wnt ligand secretion and downstream β-catenin signaling.
- Reported β-catenin reporter IC50 ~2.9 nM.
- High purity (≥95%) and crystalline solid form.
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Medchemexpress LLC FMF-04-159-2 | 2364489-81-4 | 99.5% | 1 ML
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FMF-04-159-2 is a potent covalent inhibitor targeting both CDK14 and CDK2, exhibiting IC50s of 39.6 nM and 256 nM respectively in NanoBRET assays. This compound effectively inhibits HCT116 proliferation with an IC50 of 1,144±190 nM.
- Covalent CDK14 and CDK2 inhibitor
- Potent inhibition of HCT116 proliferation
- High solubility in DMSO (≥ 100 mg/mL)
- Comprehensive documentation, including Data Sheet, COA, and SDS, is available
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