Organic sulfuric acids and derivatives
Medchemexpress LLC S-Methylisothiourea sulfate | 867-44-7 | MFCD00013055 | 99.9% | C2H6N2S.1/2H2O4S | 100 MG
S-Methylisothiourea sulfate is a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). It has shown beneficial effects in rodent models of septic shock.
- Acts as a competitive inhibitor of iNOS activity at the L-arginine site.
- Prevents NO-mediated cytotoxic effects of LPS in cultured macrophages.
- Inhibits LPS-induced nitrite production in macrophages and rat aortic vascular muscle cells.
- Reverses hypotension and vascular hyporeactivity caused by endotoxin LPS in anesthetized rats.
- Attenuates increases in plasma aminotransferases, bilirubin, and creatinine.
- Improves survival rates in mice treated with high doses of LPS.
- Restores blood pressure and inhibits iNOS activity in lung homogenates of LPS-treated rats.
Medchemexpress LLC Vinblastine (sulfate) | 143-67-9 | 99.86% | 909.05 | 100 MG
Vinblastine sulfate is a cytotoxic alkaloid that targets various cancer types by inhibiting microtubule formation and suppressing nAChR (IC50 8.9 μM). It blocks mitosis (IC50 0.8 nM in HeLa cells), leading to cell apoptosis. For storage, keep sealed at 4°C, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month, similarly sealed. Room temperature shipping is suitable for durations under 2 weeks.
- Inhibits microtubule formation.
- Suppresses nAChR with an IC50 of 8.9 μM.
- Blocks mitosis, leading to cell apoptosis.
- Induces apoptosis via Bax/Bcl-2 imbalance.
- Suppresses NFκB expression and depresses NFκB-DNA binding activity.
- Triggers apoptosis by causing a loss of mitochondrial membrane potential and activating caspases.
Medchemexpress LLC Galegine hemisulfate | 14279-86-8 | 176.23 | 5 MG
Galegine hemisulfate is a guanidine derivative that contributes to weight loss in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human kidney cell lines. It also exhibits antibacterial activity with a minimum inhibitory concentration of 4 mg/L against *Staphylococcus aureus* strains.
- Contributes to weight loss in mice
- Activates AMPK in various cell lines (3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, HEK293 human kidney cells)
- Has antibacterial activity against *Staphylococcus aureus* strains
- Stimulates insulin-independent glucose uptake by 3T3-L1 adipocytes and L6 myotubes in a concentration-dependent manner
- Reduces basal glycerol release and markedly reduces Isoprenaline-stimulated glycerol release from 3T3-L1 adipocytes
Medchemexpress LLC p-Cresyl sulfate potassium | 91978-69-7 | 99.9% | 226.29 | 50 MG
p-Cresyl sulfate potassium (Standard) is an analytical standard used in research and analytical applications. It is a uremic toxin linked to renal damage and dysfunction. This compound exhibits antiproliferation activity, influences protein expression (HIF-1α, VHL, HIF-2α), and activates JNK and p38 MAPK signaling pathways. It is suitable for experiments involving HPLC, GC, and MS.
- Analytical standard for research.
- Uremic toxin causing renal damage and dysfunction.
- Exhibits antiproliferation activity.
- Modulates protein expression (HIF-1α, VHL, HIF-2α).
- Induces epithelial-mesenchymal transition (EMT).
- Activates JNK and p38 MAPK signaling pathways.
- Applicable in HPLC, GC, and MS research.
Medchemexpress LLC Dermatan (sulphate sodium) | 54328-33-5 | 5 MG
Dermatan (sulphate sodium) | 54328-33-5 | 5 MG
Medchemexpress LLC S-Methylisothiourea sulfate | 867-44-7 | 99.9% | C2H6N2S·1/2H2O4S | 50 MG
S-Methylisothiourea sulfate | 867-44-7 | 99.9% | C2H6N2S·1/2H2O4S | 50 MG
Medchemexpress LLC S-Methylisothiourea sulfate | 867-44-7 | >99.9% | C2H6N2S·1/2H2O4S | 500 MG
S-Methylisothiourea sulfate is a potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). It has shown beneficial effects in rodent models of septic shock and is for research use only.
- Inhibits iNOS activity at the L-arginine site.
- Prevents NO-mediated cytotoxic effects of LPS in cultured macrophages.
- Exhibits inhibitory effects on LPS-induced nitrite production.
- Does not inhibit xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase.
- Reverses hypotension and vascular hyporeactivity caused by endotoxin LPS in anesthetized rats.
- Attenuates rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine after LPS administration.
- Improves 24-hour survival in mice treated with a high dose of LPS.
Medchemexpress LLC p-Cresyl sulfate | 3233-58-7 | MFCD27964764 | 99.9% | 188.20 g/mol | C7H8O4S | 5 MG
p-Cresyl sulfate is a small-molecule uremic toxin supplied as a solid or ready-to-use solution for research use. It is provided as a high-purity analytical standard suitable for biochemical assays, cell-based studies, and analytical method development.
- High purity (99.87%).
- Physical form: white to off-white solid; also available as DMSO solution.
- Molecular formula C7H8O4S; molecular weight 188.20 g/mol.
- Soluble in DMSO (250 mg/mL) and water (≥100 mg/mL).
- Store at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month).
- Suitable for biochemical and cell-based assays, and analytical method development.
Medchemexpress LLC Netilmicin (sulfate) | 56391-57-2 | 98.0% | C21H41N5O7.5/2H2SO4 | 5 MG
Netilmicin (sulfate) | 56391-57-2 | 98.0% | C21H41N5O7.5/2H2SO4 | 5 MG
Medchemexpress LLC Selumetinib sulfate | 943332-08-9 | 99.58% | C17H17BrClFN4O7S | 1 G
Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).
- Causes a time- and dose-dependent reduction in DNA synthesis and cell viability
- Induces growth arrest and apoptosis associated with the inactivation of ERK in primary cells
- Shows anti-proliferative effects through G0/G1 arrest
- Results in growth inhibition of cell lines containing B-Raf and Ras mutations
- Decreases the growth rate of xenografts in a dose-dependent manner
- Suppresses the growth of xenografts
- Inhibits ERK1/2 phosphorylation and growth of xenograft tumors in nude mice
- Tumor regressions observed in xenograft models
Medchemexpress LLC Cholesteryl sulfate sodium | 2864-50-8 | 99.86% | 488.70 | 1 ML
Cholesteryl sulfate sodium | 2864-50-8 | 99.86% | 488.70 | 1 ML
Medchemexpress LLC p-Cresyl sulfate | 3233-58-7 | 100.0% | 188.20 | 1 ML
p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin known to cause renal damage and dysfunction. It exhibits antiproliferation activity and influences the expression of HIF-1α, VHL, and HIF-2α. This compound also induces epithelial-mesenchymal transition (EMT) and activates the JNK and p38 MAPK signaling pathways.
- Shows antiproliferation activity.
- Increases protein expression of HIF-1α and VHL.
- Decreases protein expression of HIF-2α.
- Induces epithelial-mesenchymal transition (EMT).
- Activates JNK and p38 MAPK signaling pathways.
Medchemexpress LLC DBCO-dextran sulfate | 98.4% | 40,000 (average) | 10 MG
DBCO-dextran sulfate (average molecular weight 40,000) is a DBCO-functionalized dextran sulfate supplied as a powder for research use. It is used to construct DS-EXOs in cells via strain-promoted azide-alkyne click chemistry (SPAAC), and is applicable to studies such as rheumatoid arthritis research. Store powder at -20°C; in solution, store at -80°C for up to 6 months or -20°C for up to 1 month.
- DBCO-functionalized for copper-free click chemistry
- Average molecular weight 40,000
- High purity (HPLC 98.35%)
- Supplied as a powder for long-term storage stability
- Suitable for constructing DS-EXOs in cellular research models