Azobenzenes
eMolecules 2332897-85-3 | Medchem Express | Nav1.1 activator 1 | 5mg | 552386578 | HY-126429 | 440.47 | C24H23F3N4O
Ambeed | N-Methyl-2-(pyridin-2-yl)-N-(2-(pyridin-2-yl)ethyl)ethanamine | 100mg | 571783033 | A163510 | 5452-87-9 | MFCD28157290 | 241.338 | C15H19N3
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![Medchemexpress LLC 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl | 38226-86-7 | 368.38 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000416426.png-250.jpg)
Medchemexpress LLC 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl | 38226-86-7 | 368.38 | 5 MG
β-Anhydroicaritin is isolated from Boswellia carterii Birdware and possesses important biological and pharmacological effects. It ameliorates the degradation of periodontal tissue, inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats, and decreases the overproduction of NO, IL-10, TNF-α, MCP-1, and IL-6 in peritonitis mice. Additionally, it inhibits the elevation of intracellular Ca2+ and markedly decreases iNOS protein expression.
- Antiosteoporosis properties
- Estrogen regulation properties
- Antitumor properties
- Ameliorates the degradation of periodontal tissue
- Inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats
- Decreases the overproduction of NO, IL-10, TNF-α, MCP-1, and IL-6 in peritonitis mice
- Inhibits the elevation of intracellular Ca2+
- Markedly decreases iNOS protein expression
Medchemexpress LLC Triptonine B | 168009-85-6 | 1 MG
Triptonine B is a sesquiterpene pyridine alkaloid. It functions as an inhibitor of HIV replication, specifically in H9 lymphocytes, demonstrating an EC50 value of less than 0.10 μg/mL. This compound is intended for research use only and is characterized as a white to off-white solid with a high purity of 99.83%. It has a molecular weight of 967.87 and a chemical formula of C46H49NO22. Triptonine B is classified within the terpenoid and sesquiterpene categories and is naturally sourced from plants of the Celastraceae family, particularly *Tripterygium wilfordii Hook. f.*
- Inhibits HIV replication in H9 lymphocytes
- EC50 value of less than 0.10 μg/mL
- High purity of 99.83%
- Molecular weight of 967.87
- Chemical formula C46H49NO22
- Derived from *Tripterygium wilfordii Hook. f.*
![Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387730-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N' | 1166393-85-6 | 98.6% | 445.52 | 50 MG
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. It may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects, and for targeted bone regeneration.
- Potent and selective PYK2 inhibitor with an IC50 of 637 nM.
- Promotes osteogenesis of hMSC cultures, increasing alkaline phosphatase (ALP) activity and mineralization.
- Enhances osteoblast proliferation.
- Enhances calcium deposition.
- Increases cell proliferation activity in murine bone marrow-derived mesenchymal stem cells (BMSC).
Medchemexpress LLC Voacamine | 3371-85-5 | 10 MG
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. It inhibits nuclear translocation and enhances the effect of Doxorubicin by interfering with P-glycoprotein (P-gp) function. It promotes apoptosis-independent autophagic cell death in human osteosarcoma cells, activates the mitochondrial-associated apoptosis signaling pathway, and inhibits the PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Voacamine also inhibits EGFR to exert oncogenic activity against colorectal cancer.
- High purity of 99.64%
- Inhibits nuclear translocation
- Enhances Doxorubicin efficacy by interfering with P-gp function
- Promotes apoptosis-independent autophagic cell death
- Suppresses breast cancer progression via PI3K/Akt/mTOR pathway inhibition
- Exerts oncogenic activity against colorectal cancer by inhibiting EGFR
Medchemexpress LLC Manool | 596-85-0 | 290.48 | 50 MG
Manool is a diterpene derived from Salvia officinalis. It selectively induces cytotoxicity in cancer cells and arrests them at the G(2)/M phase of the cell cycle. Manool has shown higher cytotoxic activity against HeLa (IC50=6.7 μg/mL) and U343 (IC50=6.7 μg/mL) cells. Additionally, it exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells.
- Diterpene from Salvia officinalis.
- Induces selective cytotoxicity in cancer cells.
- Arrests cancer cells at the G(2)/M phase of the cell cycle.
- Exhibits protective effect against chromosome damage.
![eMolecules 17016-85-2 | (S)-4-ISOBUTYLOXAZOLIDIN-2-ONE | AstaTech | MFCD06656594 | 143.186 | C7H13NO2 | 95.000 | CC(C)C[C@H]1COC(=O)N1 | 0.25g | 411872068](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502459041.PNG-250.jpg)
eMolecules 17016-85-2 | (S)-4-ISOBUTYLOXAZOLIDIN-2-ONE | AstaTech | MFCD06656594 | 143.186 | C7H13NO2 | 95.000 | CC(C)C[C@H]1COC(=O)N1 | 0.25g | 411872068
(S)-4-ISOBUTYLOXAZOLIDIN-2-ONE | AstaTech | 17016-85-2 | MFCD06656594 | 143.186 | C7H13NO2 | 95.000 | CC(C)C[C@H]1COC(=O)N1 | 0.25g | 411872068
Medchemexpress LLC Cdc7-IN-5 (compound I-B) | 1402057-86-6 | 96.7% | C25H23N3O5 | 10MG
Cdc7-IN-5 is a small-molecule inhibitor of the CDC7 serine-threonine kinase used in research on DNA replication and cell cycle regulation. The compound is provided as a dry solid with molecular formula C25H23N3O5, molecular weight 445.47, and reported purity around 96.7%.
- Inhibits CDC7 kinase activity in biochemical and cellular assays.
- Useful for studies of DNA replication and cell cycle control.
- Supplied as a dry solid with high reported purity for research use.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Available in research-scale quantities, including 10 mg and sample sizes.
eMolecules 185259-85-2 | Medchem Express | GR-46611 | 5mg | 724441955 | HY-101248 | MFCD00953517 | 377.488 | C23H27N3O2
Medchem Express | PARP10|15-IN-3 | 5mg | 761041080 | HY-146502 | 2892064-88-7 | 274.320 | C15H18N2O3
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Medchemexpress LLC Voacamine | 3371-85-5 | 5 MG
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. It can inhibit nuclear translocation. Voacamine enhances the effect of Doxorubicin by interfering with P-glycoprotein (P-gp) function. It promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates the mitochondrial-associated apoptosis signaling pathway and inhibits the PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Additionally, Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer.
- Indole alkaloid
- Acts as a cannabinoid 1 (CB1) antagonist
- Enhances Doxorubicin effect through P-gp interference
- Promotes autophagic cell death in osteosarcoma cells
- Suppresses breast cancer progression by inhibiting PI3K/Akt/mTOR signaling
- Exerts oncogenic activity against colorectal cancer by inhibiting EGFR
Medchemexpress LLC Apiopaeonoside | 100291-86-9 | 5 MG
Apiopaeonoside is a natural product that has been isolated from the root of *Paeonia suffruticosa*. It is intended for research use only.
- Purity: 99.81%
- Molecular weight: 460.43
- Formula: C20H28O12
- Appearance: Solid
- Color: White to off-white
- Structure classification: Phenols
- Initial source: Plants (other families)
eMolecules 877874-85-6 | Medchem Express | KG5 | 5mg | 713704945 | HY-15198 | MFCD27665470 | 459.45 | C20H16F3N7OS
Medchem Express | KG5 | 5mg | 713704945 | HY-15198 | 877874-85-6 | MFCD27665470 | 459.450 | C20H16F3N7OS
Medchemexpress LLC C-021 | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 25 MG
C-021 is a small-molecule CCR4 antagonist supplied for research use. It inhibits CCR4-mediated chemotaxis in human and mouse cells and blocks CCL22-induced GTPγS binding, making it suitable for biochemical and cellular assays.
- Target: CCR4 (GPCR), suitable for immunology and GPCR research.
- Potent CCR4 antagonist with reported IC50s of 140 nM (human chemotaxis), 39 nM (mouse chemotaxis), and 18 nM in GTPγS binding assays.
- Molecular formula C27H41N5O2 and molecular weight 467.65 g/mol.
- Reported purity 99.95% and solid appearance (off-white to light yellow).
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or animal therapeutic use.
Medchemexpress LLC 2-(2,2,3,3,3-pentafluoropropoxy)-3-(4-(2,2,2-trifluoroethoxy)phenyl)-5,7-dihydropyrrolopyrimidine-4,6-dione | 1236767-85-3 | 99.9% | 473.27 | C17H11F8N3O4 | 100 MG
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor supplied as a powder for research use. It shows low-nanomolar potency (IC50 22 nM human, 72 nM rat), has molecular weight 473.27, and is reported at high purity (99.9%). Preclinical studies indicate improved insulin sensitivity and weight reduction in diet-induced obese mice. Store and handle per the manufacturer's recommendations.
- Selective delta-5 desaturase inhibitor with low-nanomolar potency.
- High purity suitable for pharmacology studies (99.9%).
- Powder form, convenient for formulation and dosing.
- Suitable for in vitro and in vivo pharmacology studies.
- Certificate of analysis and safety data sheet available.
- Defined storage conditions for powder and solutions to preserve stability.