Azobenzenes
Medchemexpress LLC GSK1702934A | 924377-85-5 | 99.11% | 395.52 | 10 MG
GSK1702934A is a selective agonist for TRPC3, a transient receptor potential canonical channel. It plays a role in modulating cardiac contractility and arrhythmogenesis through the activation of TRPC3. In vitro studies have shown its ability to induce TRPC3/6-currents in HEK293 cells, with EC50 values of 0.08 mM for TRPC3 and 0.44 mM for TRPC6. It also induces transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes, and promotes NCX currents. In vivo, GSK1702934A has been observed to transiently increase blood pressure in conscious Sprague Dawley rats at doses ranging from 0.3-3 mg/kg.
- Acts as a selective agonist for TRPC3.
- Modulates cardiac contractility and arrhythmogenesis by activating TRPC3.
- Induces TRPC3/6-currents in HEK293 cells.
- Promotes NCX currents in TRPC3-overexpressing myocytes.
- Increases blood pressure in vivo in animal models.
![Medchemexpress LLC 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide | 1450595-86-4 | Not found on authoritative sources | 99.6% | C20H21ClFN5O3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259338.png-250.jpg)
Medchemexpress LLC 5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide | 1450595-86-4 | Not found on authoritative sources | 99.6% | C20H21ClFN5O3S | 10MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor used in pain research. It shows low-nanomolar inhibition of human NaV1.7, activity in rodent models, and has demonstrated analgesic effects in preclinical studies.
- Potent NaV1.7 inhibition: hNaV1.7 IC50 = 22.8 nM; mNaV1.7 IC50 ≈ 59.4 nM.
- Orally active with reported analgesic effects in preclinical models.
- High purity, typically 99.6% by supplier specification.
- Defined chemical identity: CAS 1450595-86-4; formula C20H21ClFN5O3S; MW 465.93 g·mol⁻¹.
- Soluble in DMSO and compatible with common in vivo formulation vehicles.
- Stable as a solid with recommended refrigerated or frozen storage for long-term retention.
Medchemexpress LLC Oxypeucedanin hydrate | 2643-85-8 | 50 MG
Oxypeucedanin hydrate | 2643-85-8 | 50 MG
Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.7% | 50 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor.
- Essential for the initiation of DNA replication in the cell cycle.
- For research use only.
![eMolecules 57805-85-3 | Ambeed | Methyl 3-amino-2-benzo[b]furancarboxylate | 250mg | 525177991 | A301059 | MFCD00466275 | 191.186 | C10H9NO3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502436930.JPG-250.jpg)
eMolecules 57805-85-3 | Ambeed | Methyl 3-amino-2-benzo[b]furancarboxylate | 250mg | 525177991 | A301059 | MFCD00466275 | 191.186 | C10H9NO3
Ambeed | Methyl 3-amino-2-benzo[b]furancarboxylate | 250mg | 525177991 | A301059 | 57805-85-3 | MFCD00466275 | 191.186 | C10H9NO3
![Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000263530.png-250.jpg)
Medchemexpress LLC Ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate | 947669-86-5 | MFCD28160857 | 99.7% | 466.53 | C29H26N2O4 | 5 MG
WWL113 is a selective, orally active small-molecule inhibitor of carboxylesterases Ces3 and Ces1f used in biochemical and in vivo research to probe lipid metabolism and metabolic syndrome. It has shown efficacy in mouse models, improving lipid and glucose parameters after oral dosing.
- Selective Ces3 and Ces1f inhibitor with potent activity.
- Demonstrated in vivo efficacy in metabolic disease models.
- High purity suitable for research applications.
- Soluble in DMSO and formulatable for in vivo dosing protocols.
- Applicable to biochemical, cell-based, and animal studies.
Medchemexpress LLC Apiopaeonoside | 100291-86-9 | 99.8% | 460.43 g/mol | C20H28O12 | 10 MG
Apiopaeonoside is a naturally occurring glycoside isolated from the root of Paeonia suffruticosa, provided as a research-grade reagent for biochemical and pharmacological studies. It has formula C20H28O12, a molecular weight of 460.43 g/mol, and is supplied in high purity for experimental applications.
- High purity: 99.8%.
- Molecular formula C20H28O12.
- Molecular weight 460.43 g/mol.
- Available as solid and as 10 mM solution in DMSO.
- Intended for biochemical and pharmacological research use.
Medchemexpress LLC Hydrastinine | 6592-85-4 | 99.92% | 5 MG
Hydrastinine is a major alkaloid constituent in goldenseal (Hydrastis canadensis) and can be used as a haemostatic agent. Goldenseal has been used for the treatment of various ailments including gastrointestinal disturbances, urinary tract disorders, and inflammation. The five major alkaloid constituents in goldenseal are Berberine, Palmatine, Hydrastine, Hydrastinine, and Canadine.
- Molecular weight: 207.23
- Formula: C11H13NO3
- Appearance: Solid
- Color: Off-white to light brown
- Structure classification: Alkaloids, Isoquinoline Alkaloids
- Initial source: Plants, Ranunculaceae
eMolecules 25109-86-8 | ChemScene | Methyl 2-(2-bromoethyl)benzoate | 250mg | 536865715 | CS-W022777 | MFCD21340317 | 243.1 | C10H11BrO2
Ambeed | 4-Nitrobenzo-15-crown-5 | 1g | 572962026 | A480372 | 60835-69-0 | MFCD00060713 | 313.306 | C14H19NO7
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Medchemexpress LLC Ker047 (ALK2-IN-4) | 2248154-85-8 | 98.8% | 475.56 | 50 MG
KER047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. It can be used for research into metabolic diseases such as fibrodysplasia ossificans progressiva (FOP).
- Potent activin receptor-like kinase-2 (ALK2) inhibitor.
- Used for research of metabolic disease, specifically fibrodysplasia ossificans progressiva (FOP).
Medchemexpress LLC Lys006 hydrochloride | 2619563-79-8 | 429.23 | 50 MG
LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 of 2 nM. It is extracted from patent WO2015092740A1, example 29, and is for research use only. It can be used for the research of inflammatory and autoimmune disorders.
- Potent inhibitor of LTA4H hydrolase
- IC50 of 2 nM
- Used for research on inflammatory and autoimmune disorders
- Currently in Phase 2 clinical trials for inflammatory acne, ulcerative colitis, hidradenitis suppurativa, and non-alcoholic fatty liver disease/nonalcoholic steatohepatitis
Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.
- Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
- Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
- Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
- Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.
Medchemexpress LLC Nimbin | 5945-86-8 | 1 MG
Nimbin is an orally active intermediate limonoid found in Azadirachta. It prevents tau aggregation, increases cell viability, and effectively inhibits the envelope protein of the dengue virus. It shows promise for research in neurodegenerative diseases and viral infections.
- Prevents tau aggregation
- Increases cell viability
- Effectively inhibits the envelope protein of the dengue virus
- Possesses anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer, and anti-viral properties
- Promising for research in neurodegenerative diseases and viral infections