Azobenzenes
Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.
- Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
- Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
- Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
- Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
- Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.
eMolecules 924377-85-5 | Medchem Express | GSK1702934A | 5mg | 533802300 | HY-111098 | MFCD08868156 | 395.52 | C22H25N3O2S
Medchem Express | GSK1702934A | 5mg | 533802300 | HY-111098 | 924377-85-5 | MFCD08868156 | 395.520 | C22H25N3O2S
eMolecules 1262771-85-6 | AstaTech | (4-ETHYLTHIAZOL-2-YL)METHANAMINE DIHYDROCHLORIDE | 1g | 718080323 | AT34437 | 95 | MFCD09864312 | 215.14 | C6H12Cl2N2S
Ambeed | 4-(Pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-34-dihydrobenzo[f][14]oxazepin-5(2H)-one hydrochloride | 1mg | 534568661 | A642597 | 1448754-43-5 | MFCD30377215 | 451.830 | C21H17ClF3N3O3
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Medchemexpress LLC Cdc7-IN-5 | 1402057-86-6 | 96.7% | 50 MG
Cdc7-IN-5 is a potent Cdc7 kinase inhibitor extracted from patent WO2019165473A1. Cdc7 is a serine-threonine protein kinase enzyme which is essential for the initiation of DNA replication in the cell cycle.
- Potent Cdc7 kinase inhibitor.
- Essential for the initiation of DNA replication in the cell cycle.
- For research use only.
Medchemexpress LLC DS-1971a | 1450595-86-4 | 99.3% | 50 MG
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 nM for hNaV1.7 and 59.4 nM for mNaV1.7. It exerts analgesic effects and addresses thermal hyperalgesia and mechanical hypersensitivity.
- Potent, selective, and orally active NaV1.7 inhibitor
- Inhibitory concentration (IC50) of 22.8 nM for hNaV1.7
- Exerts analgesic effects
- Soluble in DMSO at 100 mg/mL
- Powder stable for 3 years at -20°C and 2 years at 4°C
- Stable in solvent for 2 years at -80°C and 1 year at -20°C
- Targets sodium channel membrane transporter/ion channel
- Exhibits a favorable toxicological profile
Medchemexpress LLC Sudoxicam 50mg | 34042-85-8 | 50MG
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class Sudoxicam has potent anti-inflammatory anti-edema and antipyretic activity[1 [2 [3
![eMolecules 75265-85-9 | 2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502468377.JPG-250.jpg)
eMolecules 75265-85-9 | 2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971
2-OXOCYCLOHEXANECARBOXYLIC ACID SODIUM SALT | AstaTech | 75265-85-9 | MFCD30530423 | 164.136 | C7H9NaO3 | 95.000 | [Na+].[O-]C(=O)C1CCCCC1=O | 0.25g | 296378971
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 100 MG
Valategrast (R-411 free base) is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, showing potential for treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It features a l-phenylalanine-N-aroyl motif, with its carboxylic acid binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- CAS no.: 220847-86-9
- Molecular weight: 604.95
- Formula: C30H32Cl3N3O4
- Appearance: Off-white to light yellow solid
- Solubility: ≥ 4.25 mg/mL (7.03 mM) in various in vivo dissolution methods
- Storage: -80°C, stored under nitrogen
![eMolecules 52687-85-1 | Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502516461.JPG-250.jpg)
eMolecules 52687-85-1 | Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651
Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride | ChemScene | 52687-85-1 | MFCD02685079 | 170.600 | C7H7ClN2O | 95.000 | Cl.O=C1CN2C=CC=CC2=N1 | 250mg | 569143651
eMolecules 136381-85-6 | Medchem Express | Lintitript | 5mg | 506403383 | HY-101764 | MFCD00868618 | 411.86 | C20H14ClN3O3S
Ambeed | 14-Dimethyl-1H-indole-3-carbaldehyde | 250mg | 525880699 | A438363 | 170489-16-4 | MFCD11505328 | 173.215 | C11H11NO
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