Azolines
Medchemexpress LLC Hexa(ethylene glycol) dithiol | 89141-22-0 | 500 MG
Hexa(ethylene glycol) dithiol, also known as Thiol-PEG5-thiol (Bis-PEG5-thiol), is a bifunctional thiol cross-linker agent. It is intended for research and development applications, specifically targeting biochemical assay reagents. The chemical has a formula of C12H26O5S2 and a molecular weight of 314.46.
- Bifunctional thiol cross-linker agent
- Targets biochemical assay reagents
- Chemical formula: C12H26O5S2
- Molecular weight: 314.46
- Relative density: 1.113 g/cm³ at 25 °C
- Flash point: >110 °C
- Recommended storage at 2-8 °C
- Handle under nitrogen, protected from moisture
Medchemexpress LLC Thiol-PEG8-acid | 866889-02-3 | 97.0% | 250 MG
Thiol-PEG8-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs function by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC VH 101, thiol | 2358775-81-0 | 98.7% | C25H31FN4O4S2 | 100 MG
VH 101, thiol (compound 20) is a VHL ligand used for the synthesis of PROTACs.
- Acts as a VHL ligand for the synthesis of PROTACs.
- Appears as a solid.
- Soluble in DMSO (100 mg/mL).
- Applicable in cancer and cancer targeted therapy research.
- Part of the PROTAC ligands for E3 ligase category.
- Can be found in the ubiquitination compound library.
- Inhibits E3 ligase-recruiting moiety.
- Target for biological activity is VHL.
- Molecular weight is 534.67.
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF568 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Red fluorescent CF568 has Ex/Em at 562/583 nm One labeling of 20-50 ug Nanobody Thiol per kit
Medchemexpress LLC Thiol-PEG-CH2COOH (MW 2000) | 95.0% | 25 MG
Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Thiol-PEG-CH2COOH | 95.0% | HS-(CH2-CH2-O)n-CH2COOH | 25 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. PROTACs utilize two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Target proteins selectively degraded
- Average molecular weight of 5000
- Purity of 95.0% by NMR
- Appearance is white to off-white solid
Medchemexpress LLC 1H-Benzimidazole, 2-(2-pyridinyl)- | 1137-68-4 | 99.9% | 195.22 | 10 G
2-(2′-Pyridyl)benzimidazole is a potentially tridentate ligand capable of forming stable complexes with various transition metal ions. It functions as an anti-inflammatory agent and effectively inhibits Escherichia coli methionine aminopeptidase, making it suitable for biochemical research. This compound appears as a solid, ranging from pale purple to purple or colorless to light pink and is intended for research use only.
- Functions as an anti-inflammatory agent
- Inhibits Escherichia coli methionine aminopeptidase
- IC50 of 13.3 μM in inhibiting human MetAP2 expressed in Sf9 cells
- Molecular formula: C12H9N3
- Molecular weight: 195.22
- Purity: 99.88%
- Ships at room temperature
- Stable for up to 3 years at room temperature
- Consistent with 1H NMR spectrum and LCMS
Medchemexpress LLC Thiol-PEG2-acid | 1379649-73-6 | 96.0% | 194.25 | 50 MG
Thiol-PEG2-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These innovative molecules exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins. Comprising two distinct ligands connected by a linker, PROTACs offer a promising approach for targeted therapeutic development by actively removing disease-causing proteins. Thiol-PEG2-acid serves as a crucial linker component in assembling these complex PROTAC structures.
- Peg-based protac linker
- Used in the synthesis of protacs
- Facilitates targeted protein degradation via the ubiquitin-proteasome system
Medchemexpress LLC VH032 thiol | 2098836-54-3 | 95.9% | 490.64 | 1 ML
VH032 thiol (VHL ligand 6) is a VHL ligand. It binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. VHL is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. It is also one of the most popular E3 ligases recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
- Binds to JQ1 to form PROTACs.
- Recruits VHL E3 ligase for protein degradation.
- Useful in the study of Proteolysis-targeting chimeras.
Biotium Antibody Labeling Kits Antibody and Protein Labeling Kits Mix n Stain Antibody Labeling Kits CF680 1/EA
Mix-n-Stain CF Dye Nanobody Thiol Labeling Kits are optimized for labeling nanobodies with bright and photostable CF dyes in 2 hours with no purification Kits tolerate common stabilizers Far-red/near-IR CF680 dye has Ex/Em at 681/698 nm One labeling of 5-20 ug Nanobody Thiol per kit
Medchemexpress LLC m-PEG-thiol (MW 20000) | 95.0% | 50 MG
m-PEG-thiol (MW 20000) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs operate by connecting two different ligands, one for an E3 ubiquitin ligase and another for a target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is for research use only and has not been validated for medical applications.
- PEG-based PROTAC linker
- Designed for PROTAC synthesis
- Facilitates selective degradation of target proteins
- Average molecular weight of 20000
- Appears as a white to off-white solid
- Purity of 95.0%
Medchemexpress LLC m-PEG-thiol | 134874-49-0 | MFCD21363241 | 90.0% | 750 Da (average) | (C2H4O)nC3H8OS | 500 MG
m-PEG-thiol (MW 750) is a methoxy-terminated polyethylene glycol with a terminal thiol group used for bioconjugation and surface modification. It provides a hydrophilic spacer for attaching biomolecules and for stabilizing or functionalizing metal nanoparticles via thiol-metal chemistry.
- Average molecular weight 750 Da.
- Thiol-terminated methoxy polyethylene glycol for surface attachment.
- Suitable for DNA thiolation and gold nanoparticle functionalization.
- Purity 90.0%.
- Liquid, colorless to light yellow; store cold (pure form -20°C) to preserve stability.