Biotin and derivatives
Medchemexpress LLC Diazo biotin-PEG3-azide | 1339202-33-3 | 95.5% | C33H45N9O7S | 25 MG
Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that have DBCO or BCN groups. PROTACs themselves consist of two different ligands linked together, one targeting an E3 ubiquitin ligase and the other a specific protein, leveraging the intracellular ubiquitin-proteasome system to degrade target proteins selectively.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Features an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
Medchemexpress LLC Azido-PEG3-O-NHS ester | 2110448-98-9 | C13H20N4O8 | 25 MG
Azido-PEG3-O-NHS ester | 2110448-98-9 | C13H20N4O8 | 25 MG
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | MFCD23381190 | >97.0% | 501.49 g/mol | C20H31N5O10 | 50 MG
DOTA-NHS-ester is an activated N-hydroxysuccinimide (NHS) ester of the DOTA chelator used to conjugate DOTA to amine-containing molecules for radiolabeling and imaging applications. It is intended for research use and is typically used to prepare peptide or antibody conjugates for small-animal PET, SPECT, and CT studies.
- Activated NHS-ester for amine conjugation.
- Used to prepare conjugates for PET, SPECT, and CT imaging.
- Suitable for labeling radiotherapeutic agents and imaging probes.
- Molecular weight approximately 501.49 g/mol.
- Stored sealed and away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | MFCD21363287 | 98.0% | 884.92 | C38H64N2O21 | 50 MG
Bis-PEG13-NHS ester is a bifunctional PEG-based linker containing N-hydroxysuccinimide (NHS) ester reactive groups that enable efficient amine conjugation; it is used as a cleavable linker in antibody-drug conjugate and PROTAC synthesis and for general bioconjugation chemistry.
- contains N-hydroxysuccinimide (NHS) ester reactive groups.
- functions as a cleavable linker for ADC and PROTAC synthesis.
- molecular formula C38H64N2O21, molecular weight 884.92.
- cas number 2221949-00-2 for unambiguous identification.
- purity 98.0% suitable for research applications.
- available in a 50 MG pack suitable for lab-scale synthesis.
- intended for research use only; not for human or clinical use.
Medchemexpress LLC Bis-PEG6-NHS ester | 1526718-98-8 | 98.0% | 576.55 g/mol | C24H36N2O14 | 50 MG
Bis-PEG6-NHS ester is a PEG-based bifunctional linker bearing two N-hydroxysuccinimide (NHS) ester termini separated by a six-unit polyethylene glycol spacer. It is used to conjugate amine-containing ligands in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates (ADCs).
- High purity (98.0%).
- Two NHS ester termini for efficient amine coupling.
- PEG6 spacer provides aqueous solubility and conformational flexibility.
- Suitable as a cleavable linker in ADC construction and for PROTAC linker design.
- Store sealed at -20 °C, away from moisture; unstable in solution, prepare fresh as needed.
Medchemexpress LLC PC biotin-PEG3-NHS ester | 2353409-93-3 | 840.89 | C36H52N6O15S | 10 MG
PC Biotin-PEG3-NHS ester is a cleavable 3-unit polyethylene glycol (PEG3) biotinylation reagent bearing an N-hydroxysuccinimide (NHS) active ester. It is used as a cleavable ADC linker and for biotinylation of primary amines in peptides, proteins, and other biomolecules to enable affinity capture or detection. The product is supplied as a solid and should be stored as a powder at -20°C; solutions have shorter storage lifetimes. Handle only by trained personnel for research use.
- Cleavable PEG3 biotin linker for ADC conjugation and labeling
- Reactive NHS ester for selective labeling of primary amines
- Molecular weight 840.89 and formula C36H52N6O15S
- Solid appearance; store powder at -20°C for long-term stability
- Intended for laboratory research use only
Medchemexpress LLC N-Mal-N-bis(PEG2-NHS ester) | 2182601-73-4 | 98.9% | C29H38N4O15 | 25 MG
N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs employ two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These compounds leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Supports synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Store at -20°C, protected from light and under nitrogen
- Soluble in DMSO (100 mg/mL)
![Medchemexpress LLC 1H-thieno[3,4-d]imidazole-4-pentanamide, N-[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl] | 188682-72-6 | MFCD00213997 | 99.9% | 533.68 g·mol⁻¹ | C26H39N5O5S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000288114.png-250.jpg)
Medchemexpress LLC 1H-thieno[3,4-d]imidazole-4-pentanamide, N-[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl] | 188682-72-6 | MFCD00213997 | 99.9% | 533.68 g·mol⁻¹ | C26H39N5O5S | 10 MG
Biotin-BMCC is a maleimide-activated biotinylation reagent that reacts selectively with free thiol groups of cysteines to install a biotin tag for detection, affinity capture, or purification of proteins and peptides.
- Reacts selectively with free thiol groups (cysteines).
- Introduces a biotin handle compatible with streptavidin/avidin affinity methods.
- High chemical purity (99.9%).
- Suitable for labeling proteins and peptides for detection and affinity purification.
Medchemexpress LLC Boc-NH-PEG2-C2-NHS ester | 2183440-73-3 | ≥98.0% | C16H26N2O8 | 500 MG
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are compounds designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins, functioning by connecting two ligands: one for an E3 ubiquitin ligase and one for the target protein. This compound appears as a white to off-white solid.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Appears as a white to off-white solid
- For research use only
Medchemexpress LLC m-PEG24-NHS ester | 2395839-96-8 | 99.7% | 25 MG
m-PEG24-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins, offering a novel approach in therapeutic development. This product is intended for research use only and is supplied as a white to off-white solid.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
- Stable under recommended storage conditions
eMolecules 58-85-5 | D-(+)-Biotin | Apollo Scientific US | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 5g | 870070951
D-(+)-Biotin | Apollo Scientific US | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 5g | 870070951
Medchemexpress LLC m-PEG-NHS ester (MW 10000) | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 1 G
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two distinct ligands joined by a linker: one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system to degrade target proteins
- Solid, white to off-white appearance
- For research use only
eMolecules 1807518-72-4 | Mal-PEG1-NHS ester | Ambeed | MFCD26127783 | 310.262 | C13H14N2O7 | 97.000 | O=C(CCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 5g | 794508519
Mal-PEG1-NHS ester | Ambeed | 1807518-72-4 | MFCD26127783 | 310.262 | C13H14N2O7 | 97.000 | O=C(CCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 5g | 794508519
Medchemexpress LLC m-PEG11-NHS ester | 3119903-67-9 | C28H51NO15 | 100 MG
m-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is recommended for storage at -20°C, sealed, and away from moisture and light. If in solvent, it can be stored at -80°C for 6 months or -20°C for 1 month, also with sealed storage, away from moisture and light.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Store at -20°C, sealed, away from moisture and light
- Extended storage in solvent possible at -80°C
![eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471012.jpg-250.jpg)
eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208
Biotin | Ambeed | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208