Cycloheptathiophenes
Apexbio Technology LLC Ketotifen Fumarate 34580-14-8 1g
Ketotifen fumarate is a noncompetitive antagonist of histamine H1 receptors and functions additionally as a mast cell stabilizer It inhibits histamine-mediated allergic responses through preventing histamine receptor activation and limiting mast cell degranulation Its pharmacological activity involves suppression of calcium influx into mast cells thus inhibiting histamine release Ketotifen fumarate is extensively utilized in biomedical research focusing on allergy and asthma pathophysiology to assess mast-cell-mediated mechanisms and histamine signaling pathways In vitro studies report its IC50 values ranging approximately from 0 8 to 2 5 M depending on assay parameters and cell types This compound commonly serves as a pharmacological tool when investigating allergic inflammation asthma and histamine-dependent cellular events
Apexbio Technology LLC Hoechst 34580 23555-00-2 100mg
Hoechst 34580 is a blue-fluorescent dye routinely employed in biomedical research for labeling cell nuclei and analyzing cell-cycle progression This dye binds selectively to nucleic acids predominantly by interacting with DNA via minor groove binding allowing visualization of nuclear morphology and chromatin structure Upon binding DNA Hoechst 34580 exhibits fluorescence excitation around 392 nm and emission maxima near 440 460 nm suitable for standard fluorescent microscopy Typical working concentrations for cell labeling range between 0 5 and 10 g/mL Due to these characteristics Hoechst 34580 is widely used for fluorescence microscopy flow cytometry nuclear staining applications and monitoring cellular proliferation in biological investigations
Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 g/mol | C31H39FN2O8 | 5 MG
VUF11207 fumarate is a research-grade small-molecule agonist of the chemokine receptor CXCR7 (ACKR3). It selectively binds CXCR7 and has been reported to reduce CXCL12-mediated osteoclastogenesis and bone resorption through inhibition of ERK phosphorylation. The compound is supplied for laboratory research use only.
- Selective CXCR7 agonist with reported activity in CXCL12 signaling.
- Reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.
- High purity suitable for in vitro studies (99.94%).
- Available as solid and as a 10 mM solution in DMSO; multiple solid package sizes available.
- Intended for research use only; not for human or veterinary use.
- Applicable to receptor pharmacology and cell-based signaling assays.
Medchemexpress LLC Rupatadine fumarate | 182349-12-8 | MFCD00926499 | 97.3% | C30H30ClN3O4 | 10MG
Rupatadine fumarate is an analytical reference standard supplied as a 10 mg pack for research and analytical applications. It corresponds to CAS 182349-12-8, has a molecular formula of C30H30ClN3O4, a molecular weight of 532.03, and is provided with a stated purity of approximately 97.3%. For laboratory research use only.
- Intended for analytical, method development, and validation use.
- Available in a 10 mg pack size.
- Molecular formula C30H30ClN3O4 and molecular weight 532.03.
- Listed purity 97.3%.
- Provided for laboratory research use only.
Apexbio Technology LLC GR 89696 fumarate 126766-32-3 50mg
GR 89696 fumarate (CAS 126766-32-3) is a selective agonist of the 2-opioid receptor By specifically activating 2 subtypes this small molecule modulates neural signaling pathways implicated in sensory processing particularly pain and pruritus Experimental studies have demonstrated that GR 89696 fumarate induces physiological effects in the nervous system through 2-opioid receptor activation This compound has been widely utilized as a pharmacological tool in the investigation of neurocutaneous disorders and the underlying mechanisms of opioid receptor-mediated modulation of somatosensory functions
Medchemexpress LLC Ocifisertib fumarate | 1616420-30-4 | 99.3% | 650.72 Da | C37H38N4O7 | 5MG
Ocifisertib fumarate is the fumarate salt of Ocifisertib (CFI-400945), a potent, selective, orally bioavailable inhibitor of polo-like kinase 4 (PLK4) used as a research tool in oncology and cell biology to study centriole duplication and mitotic defects. Reported potency values support activity in biochemical and cellular assays.
Medchemexpress LLC Iron(II) fumarate (Ferrous fumarate) | 141-01-5 | 95.1% | 500 MG
Iron(II) fumarate is an orally effective active dietary supplement. It can alleviate metabolic damage and damage to silkworms caused by cypermethrin and can be used for research on iron deficiency anemia.
- Orally effective active dietary supplement.
- Can alleviate metabolic damage and damage to silkworms caused by cypermethrin.
- Can be used for research on iron deficiency anemia.
- In vitro, can restore metabolic pathway disruption caused by cypermethrin, enhance the tolerance and cell viability of BmN cells to cypermethrin.
- In vivo, can alleviate the damage of cypermethrin to silkworms.
- In vivo, can alter the intestinal morphology and microbiota of Yellow River carp, promoting the development of intestinal villi and increasing the thickness of the intestinal muscle layer.
TARGETMOL CHEMICALS INC Fumarate hydratase-IN-1 2MG
Also available in 1 mL, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity. Purity 98.96%
Selleck Chemical LLC Bedaquiline fumarate S4854-5mg
Bedaquiline fumarate (TMC-207) an oral diarylquinoline is a bactericidal antimycobacterial drug It is a proton-translocating ATP synthetase inhibitor
TARGETMOL CHEMICALS INC Ro 48-8071 fumarate 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Ro 48-8071 fumarate, an inhibitor of OSC (Oxidosqualene cyclase; IC50=6.5 nM), exhibits LDL (low-density lipoprotein) cholesterol-lowering activity. Purity 99.32%
Medchemexpress LLC Clemastine fumarate | 14976-57-9 | 100.0% | 200 MG
Clemastine fumarate | 14976-57-9 | 100.0% | 200 MG
Medchemexpress LLC Crozbaciclib fumarate | 2567494-39-5 | 99.4% | 604.65 g/mol | C32H34F2N6O4 | 5 MG
Crozbaciclib fumarate is the fumarate salt of crozbaciclib, a small-molecule cyclin-dependent kinase inhibitor selective for CDK4 and CDK6, provided for laboratory research. It exhibits low-nanomolar biochemical potency (CDK4 IC50 ≈ 3 nM; CDK6 IC50 ≈ 1 nM) and demonstrates antiproliferative activity in cellular assays.
- Fumarate salt form for improved chemical stability.
- Potent inhibition of CDK4 and CDK6 (low-nanomolar IC50s).
- High chemical purity (reported 99.4%).
- Supplied in small milligram quantities for research use.