Cycloheptathiophenes
Medchemexpress LLC Cevipabulin fumarate | 849550-67-0 | MFCD31813783 | 99.9% | 580.89 g/mol | C22H22ClF5N6O5 | 10 MG
Cevipabulin fumarate is the fumarate salt of a microtubule-active small-molecule antitumor agent supplied for laboratory research use. It inhibits tubulin binding, disrupts microtubule dynamics, and produces cytotoxic effects in human tumor cell lines; supplied as a solid with specified storage conditions for stability.
- Microtubule-active mechanism that disrupts tubulin dynamics.
- High chemical purity suitable for research applications.
- Solid, white to off-white physical form for easy handling and storage.
- Storage conditions provided for solid and solution forms to preserve stability.
- Available in small research pack sizes for preclinical studies.
Medchemexpress LLC Fesoterodine (fumarate) | 286930-03-8 | MFCD09835695 | ≥98% | 574.67 | 10 MG
Fesoterodine fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It is used for the overactive bladder (OAB).
- Orally active
- Nonsubtype selective
- Competitive muscarinic receptor (mAChR) antagonist
- Targets mAChR
- Used for overactive bladder (OAB)
- Research areas include neurological disease, metabolic disease, and cancer
Medchemexpress LLC Vonoprazan Fumarate (TAK-438) | 881681-01-2 | MFCD18633280 | C21H20FN3O6S | 1 ML
Vonoprazan Fumarate (TAK-438) is a potent and orally active potassium-competitive acid blocker (P-CAB) developed for research into acid-related diseases such as gastroesophageal reflux disease and peptic ulcer disease. It functions as a proton pump inhibitor (PPI) and exhibits antisecretory activity.
- Potent and orally active potassium-competitive acid blocker (P-CAB)
- Proton pump inhibitor (PPI)
- Antisecretory activity
- Inhibits H+,K+-ATPase activity with an IC50 of 19 nM at pH 6.5
Medchemexpress LLC 2-butenedioic acid (2e)-, 1-[2-(diethylamino)-2-oxoethyl] 4-methyl ester | 1208229-58-6 | 99.8% | 243.26 | 1 ML
Tepilamide fumarate is an oral fumaric acid ester that acts as a proagent of Monomethyl fumarate. It is used in the research of moderate to severe chronic plaque psoriasis and can enhance the effectiveness of oncolytic viruses. In vitro studies show that it makes 786-0 cancer cells more susceptible to infection by VSV∆51, leading to increased virus replication, and selectively promotes oncolytic virus infection in cancer cells without affecting healthy tissues.
- Oral fumaric acid ester
- Acts as a proagent of monomethyl fumarate
- Used in research of moderate to severe chronic plaque psoriasis
- Enhances the effectiveness of oncolytic viruses
- Increases susceptibility of cancer cells to viral infection
- Selectively promotes oncolytic virus infection in cancer cells
Cayman Chemical Monmethyl fumarate 250g
An active metabolite of dimethyl fumarate; an agonist of HCA2/GPR109A (EC50 = 9.4 µM); reduces neutrophil adhesion to endothelial cells stimulated with TNF, decreases CXCL2-directed neutrophil migration, and increases the expression of the Nrf2 target gene NQO1 in wild-type but not HCA2-/- macrophages; inhibits proliferation and induces differentiation in keratinocytes, as well as decreases TPA-induced levels of TNF-α in keratinocytes at 1 mM; reduces symptoms of EAE in mice at 1 mg/day
Apexbio Technology LLC Fesoterodine Fumarate 286930-03-8 10mg
Fesoterodine Fumarate (CAS 286930-03-8) is a synthetic antimuscarinic agent that acts as a competitive antagonist at muscarinic acetylcholine receptors particularly the M3 subtype in the bladder detrusor muscle By inhibiting these receptors the compound modulates involuntary bladder contractions reducing symptoms associated with overactive bladder syndrome such as urgency and frequency Fesoterodine Fumarate is utilized in biomedical research to study cholinergic signaling mechanisms involved in urinary function and to explore pharmacological interventions targeting muscarinic pathways in urological disorders
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 1 ML
Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. This compound is intended for research use only and is not sold for patient treatment. It has demonstrated efficacy in reducing cholesterol synthesis and inducing apoptosis in various cancer cell lines, as well as inhibiting tumor growth in vivo.
- Inhibits Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM.
- Reduces cholesterol synthesis with an IC50 of approximately 1.5 nM in HepG2 cells.
- Significantly reduces viability of PC-3 prostate cancer cells.
- Induces apoptosis in LNCaP and C4-2 cell lines.
- Reduces AR protein expression and increases ERβ protein expression.
- Lowers LDL-C maximally by approximately 60% in hamsters.
- Significantly reduces in vivo tumor growth in mice.
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.13% | 564.44 | 5 MG
Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It has demonstrated the ability to reduce cholesterol synthesis in HepG2 cells with an IC50 value of approximately 1.5 nM. In various cancer cell lines, Ro 48-8071 has shown cytotoxicity and can induce apoptosis. It has also been observed to lower LDL-C in hamsters and significantly reduce in vivo tumor growth in mice without causing weight loss.
- Inhibits oxidosqualene cyclase.
- Reduces cholesterol synthesis.
- Exhibits cytotoxicity against certain cancer cells.
- Induces apoptosis in specific cancer cell lines.
- Lowers ldl-c in animal models.
- Reduces in vivo tumor growth.
Medchemexpress LLC Fesoterodine fumarate | 286930-03-8 | 99.5% | C30H41NO7 | 50 MG
Fesoterodine fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It is primarily used for the treatment of overactive bladder (OAB), where it helps decrease micturition frequency, urgency severity, and urgency incontinence episodes, while increasing the volume voided.
- Orally active, nonsubtype selective mAChR antagonist
- Treats overactive bladder (OAB)
- Decreases micturition frequency, urgency severity, and urgency incontinence episodes
- Increases volume voided with each micturition
- Reduces micturition pressure
- Increases bladder capacity and intercontraction intervals (ICIs)
TARGETMOL CHEMICALS INC IBUTILIDE FUMARATE 100MG
Also available in 10 mg 25 mg 50 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow inward predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval. purity: 99%
Apexbio Technology LLC Hoechst 34580 23555-00-2 100mg
Hoechst 34580 is a blue-fluorescent dye routinely employed in biomedical research for labeling cell nuclei and analyzing cell-cycle progression This dye binds selectively to nucleic acids predominantly by interacting with DNA via minor groove binding allowing visualization of nuclear morphology and chromatin structure Upon binding DNA Hoechst 34580 exhibits fluorescence excitation around 392 nm and emission maxima near 440 460 nm suitable for standard fluorescent microscopy Typical working concentrations for cell labeling range between 0 5 and 10 g/mL Due to these characteristics Hoechst 34580 is widely used for fluorescence microscopy flow cytometry nuclear staining applications and monitoring cellular proliferation in biological investigations