Cycloheptathiophenes
Medchemexpress LLC Dofequidar (fumarate) | 153653-30-6 | 98.0% | 597.66 | 100 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. It competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, thereby increasing drug concentration in cancer cells and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 | 50 MG
VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. It reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.
- Reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation.
- Binds specifically to CXCR7.
Medchemexpress LLC 2-Butenedioic acid (2E)-, 1-ethyl ester | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 g/mol | C6H8O4 | 1 ML
Monoethyl fumarate is the monoethyl ester of fumaric acid used as a research reagent. It acts as an activator of Nrf2 and is employed as a preservative and polymerization agent for macromolecular materials. The compound is available as a ready-to-use 10 mM solution in DMSO or as a bulk solid and is provided with analytical documentation confirming high purity.
Medchemexpress LLC Pirepemat fumarate (IRL752 fumarate) | 2251806-70-7 | 98.3% | 329.30 | 1 ML
Pirepemat (IRL752) fumarate is a cognition-promoting agent that preferentially acts on the cortex, affecting catecholamine transmission. It is currently being investigated for its potential use in the treatment of Parkinson's disease.
- A cortical-preferring cognition-promoting agent.
- Used for the study of Parkinson's disease.
- Displays highest in vitro affinities for 5-HT and NA-related targets.
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Ro 48-8071 Fumarate | 189197-69-1 | 99.1% | 564.44 | 50 MG
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.13% | 564.44 | 5 MG
Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It has demonstrated the ability to reduce cholesterol synthesis in HepG2 cells with an IC50 value of approximately 1.5 nM. In various cancer cell lines, Ro 48-8071 has shown cytotoxicity and can induce apoptosis. It has also been observed to lower LDL-C in hamsters and significantly reduce in vivo tumor growth in mice without causing weight loss.
- Inhibits oxidosqualene cyclase.
- Reduces cholesterol synthesis.
- Exhibits cytotoxicity against certain cancer cells.
- Induces apoptosis in specific cancer cell lines.
- Lowers ldl-c in animal models.
- Reduces in vivo tumor growth.
Medchemexpress LLC Iron(II) fumarate (Ferrous fumarate) | 141-01-5 | 95.1% | 500 MG
Iron(II) fumarate is an orally effective active dietary supplement. It can alleviate metabolic damage and damage to silkworms caused by cypermethrin and can be used for research on iron deficiency anemia.
- Orally effective active dietary supplement.
- Can alleviate metabolic damage and damage to silkworms caused by cypermethrin.
- Can be used for research on iron deficiency anemia.
- In vitro, can restore metabolic pathway disruption caused by cypermethrin, enhance the tolerance and cell viability of BmN cells to cypermethrin.
- In vivo, can alleviate the damage of cypermethrin to silkworms.
- In vivo, can alter the intestinal morphology and microbiota of Yellow River carp, promoting the development of intestinal villi and increasing the thickness of the intestinal muscle layer.
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 50 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent and a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM).
- Cells expressing MDR1*7 show resistance (IC50: 105.3 nM vs 27.4 nM).
- Prolongs cardiac repolarization in vitro and in vivo.
- Cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., 10-min infusion) resulted in polymorphic and monomorphic non-sustained ventricular tachycardia in animal models.
- Increased action potential duration at 90% (APD90) prolongation in congestive heart failure (CHF) dogs compared to controls at 0.01 mg/kg.
Medchemexpress LLC Ketotifen | 34580-13-7 | 99.7% | 50 MG
Ketotifen is an orally active, second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Additionally, it exhibits antiviral activity against SARS-CoV-2 and Influenza virus. It is used in the research of autoimmune encephalomyelitis (EAE) and for asthma attack prevention.
- Orally active, second-generation noncompetitive histamine 1 (H1) receptor blocker
- Mast cell stabilizer
- Blocks 6-phosphogluconate dehydrogenase (PGD) in vitro
- Antiviral activity against SARS-CoV-2 and Influenza virus
- Used in research of autoimmune encephalomyelitis (EAE)
- Used for asthma attack prevention
Medchemexpress LLC Vonoprazan Fumarate (TAK-438) | 881681-01-2 | MFCD18633280 | C21H20FN3O6S | 1 ML
Vonoprazan Fumarate (TAK-438) is a potent and orally active potassium-competitive acid blocker (P-CAB) developed for research into acid-related diseases such as gastroesophageal reflux disease and peptic ulcer disease. It functions as a proton pump inhibitor (PPI) and exhibits antisecretory activity.
- Potent and orally active potassium-competitive acid blocker (P-CAB)
- Proton pump inhibitor (PPI)
- Antisecretory activity
- Inhibits H+,K+-ATPase activity with an IC50 of 19 nM at pH 6.5
Medchemexpress LLC Diethyl fumarate | 623-91-6 | 98.97% | 172.18 | 100 G
Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and a reactant in the Diels-Alder reaction. It is a reputed skin irritant and can cause non-immunologic contact urticaria on the skin. When hybridized with Curcumin, Diethyl fumarate can exert neuroprotective effects.
- Reactant in the Diels-Alder reaction.
- Exerts neuroprotective effects in combination with curcumin.
- Available in various quantities (mg, g) and solutions.
- High purity (98.97%).
Medchemexpress LLC Crozbaciclib fumarate | 2567494-39-5 | 99.4% | 604.65 g/mol | C32H34F2N6O4 | 5 MG
Crozbaciclib fumarate is the fumarate salt of crozbaciclib, a small-molecule cyclin-dependent kinase inhibitor selective for CDK4 and CDK6, provided for laboratory research. It exhibits low-nanomolar biochemical potency (CDK4 IC50 ≈ 3 nM; CDK6 IC50 ≈ 1 nM) and demonstrates antiproliferative activity in cellular assays.
- Fumarate salt form for improved chemical stability.
- Potent inhibition of CDK4 and CDK6 (low-nanomolar IC50s).
- High chemical purity (reported 99.4%).
- Supplied in small milligram quantities for research use.
Medchemexpress LLC Monomethyl fumarate-d3 | 1616345-41-5 | MFCD34469902 | 99.0% | 133.117 g/mol | C5H3D3O4 | 1 MG
Monomethyl fumarate-d3 is the deuterium-labeled analogue of monomethyl fumarate, supplied as an isotopically labeled tracer and internal standard for analytical and pharmacokinetic studies. It is intended for research use in quantitative workflows where precise isotope labeling improves detection and quantitation.
- Isotopically labeled internal standard for NMR, GC-MS, and LC-MS.
- Useful as a tracer in pharmacokinetic and metabolic profiling.
- High analytical purity (≈99.0%).
- Provided in small research quantities suitable for analytical assays.
- Molecular formula C5H3D3O4; CAS 1616345-41-5.