Cycloheptathiophenes
Selleck Chemical LLC Ensitrelvir fumarate-E1131-5MG
S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent non-peptidic SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM
Medchemexpress LLC Ocifisertib fumarate | 1616420-30-4 | >98.0% | 650.7 g/mol | C37H38N4O7 | 50MG
Ocifisertib fumarate is the fumarate salt of CFI-400945, a potent, selective, and orally bioavailable inhibitor of polo-like kinase 4 (PLK4) supplied for research use in biochemical and cellular studies of PLK4-related pathways and antineoplastic activity.
- Fumarate salt form of the PLK4 inhibitor.
- Potent biochemical activity: PLK4 Ki = 0.26 nM; PLK4 IC50 = 2.8 nM.
- Molecular formula C37H38N4O7 and molecular weight 650.7 g/mol.
- High purity (>98.0% by HPLC) suitable for research applications.
- Supplied in small research pack sizes, including 50 mg.
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | MFCD10057039 | >98.0% | 255.22 | C11H13NO6 | 25 MG
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in research to investigate Nrf2 pathway activation and multiple sclerosis-related pharmacology. The compound is provided with analytical data for identification and formulation of stock solutions.
- Orally active prodrug of monomethyl fumarate.
- Useful for in vitro and in vivo studies of Nrf2-mediated pathways.
- Provided with analytical specifications including CAS, formula, and molecular weight for traceability.
- Available in mg-scale quantities suitable for preclinical research.
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | ≥98.0% | 255.23 g/mol | C11H13NO6 | 50 MG
Diroximel fumarate is supplied as a research-grade small-molecule reagent intended for laboratory studies. This listing represents a 50 MG pack of the prodrug of monomethyl fumarate and is provided for experimental and analytical use in research settings; it is not for clinical or human use.
- For research use only, not for human or clinical use.
- Supplied as a small 50 MG pack suitable for laboratory testing.
- High purity, typically ≥98.0%.
- Molecular weight 255.23 g/mol and formula C11H13NO6.
- Useful for studies of fumarate metabolism and related biochemical pathways.
Medchemexpress LLC Monomethyl fumarate | 2756-87-8 | MFCD00063174 | 100.0% | 130.10 g/mol | C5H6O4 | 1 ML
Monomethyl fumarate is the methyl ester of fumaric acid and the active metabolite of dimethyl fumarate; it acts as a GPR109A agonist and is used in biochemical and pharmacological research. The product is offered with high purity and is available as a ready-to-use solution or as solid material for analytical and preparative applications.
- High purity suitable for research applications.
- Provided as a ready-to-use 10 mM solution in DMSO (1 mL).
- Also available in solid form for bulk use or formulation.
- Well-characterized molecular data: chemical formula C5H6O4 and molecular weight 130.10 g/mol.
- Appropriate for use as a reference compound and in studies of GPR109A-mediated pathways.
Medchemexpress LLC Fumarate hydratase-I 10mM 1mL
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Apexbio Technology LLC Dimethyl Fumarate 624-49-7 10mM (in 1mL DMSO)
Dimethyl fumarate (CAS 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway It is designed to promote Nrf2 nuclear translocation and induce transcription of antioxidant response genes thereby modulating oxidative stress response pathways Dimethyl fumarate exerts its biological activity primarily through activation of Nrf2-mediated antioxidant gene expression In cell-based assays dimethyl fumarate demonstrates Nrf2 activation activity with an IC50 value of approximately 5 M Based on these pharmacological properties dimethyl fumarate holds research potential in the study of oxidative stress inflammation and related pathophysiological processes
Apexbio Technology LLC GR 89696 fumarate 126766-32-3 10mg
GR 89696 fumarate (CAS 126766-32-3) is a selective agonist of the 2-opioid receptor By specifically activating 2 subtypes this small molecule modulates neural signaling pathways implicated in sensory processing particularly pain and pruritus Experimental studies have demonstrated that GR 89696 fumarate induces physiological effects in the nervous system through 2-opioid receptor activation This compound has been widely utilized as a pharmacological tool in the investigation of neurocutaneous disorders and the underlying mechanisms of opioid receptor-mediated modulation of somatosensory functions
Apexbio Technology LLC (±)-Anatoxin A fumarate 1219922-30-1 1mg
( )-Anatoxin A fumarate (CAS 1219922-30-1) is a naturally occurring alkaloid isolated from freshwater cyanobacteria It functions as an agonist at nicotinic acetylcholine receptors exhibiting high binding affinity for rat brain 4 2 (K i 1 25 nM) and lower affinity for 7 (K i 1 84 M) subtypes In functional assays ( )-Anatoxin A fumarate induces dopamine release in rat striatal synaptosomes with an EC 50 of 134 nM This compound is utilized in neuroscience research to investigate cholinergic signaling and dopaminergic mechanisms in the central nervous system