Cycloheptathiophenes
Medchemexpress LLC Bedaquiline fumarate | 845533-86-0 | 99.98% | 671.58 | 50 MG
Bedaquiline fumarate is an analytical standard and a diarylquinoline antibiotic that targets ATP synthase. It is effective for the treatment of Mycobacterium tuberculosis infections and is intended for research and analytical applications.
- Analytical standard grade
- Reference standard supplied assay
- Effective against Mycobacterium tuberculosis infections
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Selleck Chemical LLC Fumarate hydratase-IN-1
Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase It induce alteration of TCA cycle metabolites modulation of cytosolic processes and substantial redox stress responses
Medchemexpress LLC Dofequidar Fumarate | 153653-30-6 | 98.0% | 597.66 | 1 ML
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect. It is for research use only and not sold to patients.
- Orally active quinoline compound
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp, ABCC1/MRP-1
- Blocks efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC Dofequidar (fumarate) | 153653-30-6 | 98.0% | 597.66 | 5 MG
Dofequidar fumarate (MS-209) is an orally active quinoline compound that blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). It has a highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp and ABCC1/MRP-1, blocking the efflux of chemotherapeutic agents, increasing drug concentration in cancer cells, and enhancing the chemotherapeutic effect.
- Orally active
- Blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1)
- Highly potent reversing effect on multidrug-resistant tumor cells
- Competitively inhibits ABCB1/P-gp and ABCC1/MRP-1
- Blocks the efflux of chemotherapeutic agents
- Increases drug concentration in cancer cells
- Enhances chemotherapeutic effect
Medchemexpress LLC Crozbaciclib fumarate | 2567494-39-5 | 99.4% | 604.65 | 10 MG
Crozbaciclib fumarate is a potent CDK4/6 inhibitor, demonstrating significant anti-proliferative effects by arresting the U87MG cell line exclusively in G1. It has shown promising results in vivo, including substantial tumor growth inhibition in orthotopic xenograft mouse models of glioblastoma multiforme.
- Potent CDK4/6 inhibitor with IC50s of 3 nM (CDK4) and 1 nM (CDK6).
- Acts as an anti-proliferative agent, arresting U87MG cells in G1.
- Exhibits tumor growth inhibition from 62% to 99% in glioblastoma multiforme xenograft models.
- Increases lifespan by 162% in mice at a dose of 50 mg/kg.
Medchemexpress LLC 2-Butenedioic acid (2E)-, 1,4-diethyl ester | 623-91-6 | 98.97% | 172.18 | 50 G
Diethyl fumarate is an analytical standard intended for research and analytical applications. It is a decomposition product of Malathion 9 (a pesticide) and a reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant and can cause non-immunologic contact urticaria. It can also hybridize with Curcumin to exert neuroprotective effects. The compound is of analytical standard grade and is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
- Can exert neuroprotective effects when hybridized with Curcumin
- Reactant in Diels-Alder reaction
Medchemexpress LLC Ro 48-8071 fumarate | 189197-69-1 | MFCD05865242 | 99.1% | 564.44 g/mol | C27H31BrFNO6 | 10 MG
Ro 48-8071 fumarate is a potent oxidosqualene cyclase (OSC) inhibitor used in research to block cholesterol biosynthesis and to probe cholesterol-dependent cellular pathways in vitro and in vivo. It is supplied as the fumarate salt at high purity for biochemical and cell-based studies.
- Potent oxidosqualene cyclase inhibitor (IC50 ≈ 6.5 nM).
- Suitable for cell-based and in vivo research applications.
- High purity appropriate for biochemical assays (≈99.1%).
- Provided as the fumarate salt to aid stability and handling.
- Molecular weight 564.44 g/mol for accurate dosing and calculations.
- Supplied in small research pack sizes for screening and mechanistic studies.
Selleck Chemical LLC Ferrous fumarate
Ferrous fumarate (Iron(II)) is the fumarate salt form of the mineral iron and is used in treatment of iron deficiency anemia
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 5 MG
Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic agent. It acts as a potent blocker of the rapidly activating delayed rectifier K⁺ current (IKr) in AT-1 cells. This compound is intended for research use only.
- Potent IKr blocker with an EC50 value of 20 nM in AT-1 cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as HERG alone.
- Prolongs cardiac repolarization in vitro and in vivo.
- Appears as a white to off-white solid.
- Recommended storage for solid: 4°C, sealed, away from moisture.
- Recommended storage in solvent: -80°C for 6 months, or -20°C for 1 month.
Apexbio Technology LLC Dimethyl Fumarate 624-49-7 5g
Dimethyl fumarate (CAS 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway It is designed to promote Nrf2 nuclear translocation and induce transcription of antioxidant response genes thereby modulating oxidative stress response pathways Dimethyl fumarate exerts its biological activity primarily through activation of Nrf2-mediated antioxidant gene expression In cell-based assays dimethyl fumarate demonstrates Nrf2 activation activity with an IC50 value of approximately 5 M Based on these pharmacological properties dimethyl fumarate holds research potential in the study of oxidative stress inflammation and related pathophysiological processes
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 10mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC Tepilamide fumarate | 1208229-58-6 | 99.8% | 243.26 | 25 MG
Tepilamide fumarate is an oral fumaric acid ester that acts as a proagent of Monomethyl fumarate. It is used in the research of moderate to severe chronic plaque psoriasis and can also enhance the effectiveness of oncolytic viruses.
- Acts as a proagent of Monomethyl fumarate.
- Used in research for moderate to severe chronic plaque psoriasis.
- Can enhance the effectiveness of oncolytic viruses.
- Selectively promotes oncolytic virus infection in cancer cells without affecting healthy tissues.
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | 99.9% | 255.22 g/mol | C11H13NO6 | 1 ML
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in preclinical research to probe Nrf2 pathway modulation and multiple sclerosis-related biology. Supplied as a ready-to-use solution, it is intended for laboratory research use only and not for human or clinical applications.
- Ready-to-use 10 mM solution in DMSO for immediate experimental use.
- High purity (99.90%) suitable for biochemical and cellular assays.
- Molecular weight 255.22 g/mol, molecular formula C11H13NO6.
- Prodrug of monomethyl fumarate for Nrf2 pathway and MS-related research.
- Provided in a 1 mL volume for small-scale assays and dose-response studies.
- For research use only; not for human or clinical use.
Apexbio Technology LLC Fesoterodine Fumarate 286930-03-8 5mg
Fesoterodine Fumarate (CAS 286930-03-8) is a synthetic antimuscarinic agent that acts as a competitive antagonist at muscarinic acetylcholine receptors particularly the M3 subtype in the bladder detrusor muscle By inhibiting these receptors the compound modulates involuntary bladder contractions reducing symptoms associated with overactive bladder syndrome such as urgency and frequency Fesoterodine Fumarate is utilized in biomedical research to study cholinergic signaling mechanisms involved in urinary function and to explore pharmacological interventions targeting muscarinic pathways in urological disorders
Medchemexpress LLC Dimethyl fumarate | 624-49-7 | 100.0% | 144.13 | 1 ML
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator that induces upregulation of antioxidant gene expression. It also induces necroptosis in colon cancer cells via the GSH depletion/ROS increase/MAPKs activation pathway, and promotes cell autophagy. Dimethyl fumarate is used for multiple sclerosis research.
- Orally active and brain-penetrant Nrf2 activator
- Induces upregulation of antioxidant gene expression
- Induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway
- Promotes cell autophagy
- Used for multiple sclerosis research