Cycloheptathiophenes
Medchemexpress LLC Ocifisertib fumarate | 1616420-30-4 | 99.3% | 650.72 Da | C37H38N4O7 | 5MG
Ocifisertib fumarate is the fumarate salt of Ocifisertib (CFI-400945), a potent, selective, orally bioavailable inhibitor of polo-like kinase 4 (PLK4) used as a research tool in oncology and cell biology to study centriole duplication and mitotic defects. Reported potency values support activity in biochemical and cellular assays.
Medchemexpress LLC Iron(II) fumarate (Ferrous fumarate) | 141-01-5 | 95.1% | 500 MG
Iron(II) fumarate is an orally effective active dietary supplement. It can alleviate metabolic damage and damage to silkworms caused by cypermethrin and can be used for research on iron deficiency anemia.
- Orally effective active dietary supplement.
- Can alleviate metabolic damage and damage to silkworms caused by cypermethrin.
- Can be used for research on iron deficiency anemia.
- In vitro, can restore metabolic pathway disruption caused by cypermethrin, enhance the tolerance and cell viability of BmN cells to cypermethrin.
- In vivo, can alleviate the damage of cypermethrin to silkworms.
- In vivo, can alter the intestinal morphology and microbiota of Yellow River carp, promoting the development of intestinal villi and increasing the thickness of the intestinal muscle layer.
Selleck Chemical LLC Bedaquiline fumarate S4854-5mg
Bedaquiline fumarate (TMC-207) an oral diarylquinoline is a bactericidal antimycobacterial drug It is a proton-translocating ATP synthetase inhibitor
Selleck Chemical LLC Fumarate hydratase-IN-1
Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase It induce alteration of TCA cycle metabolites modulation of cytosolic processes and substantial redox stress responses
Selleck Chemical LLC Vonoprazan Fumarate
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H /K ATPase with IC50 of 19 nM (pH 6 5) controls gastric acid secretion Phase 3
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 100 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells, playing a role in cardiac repolarization. This product is suitable for research applications in cardiac physiology and pharmacology.
- Potent IKr blocker
- Prolongs cardiac repolarization
- Relevant for studies on atrial tumor myocytes
- Useful in research related to congestive heart failure models
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 5mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC Pirepemat fumarate (IRL752 fumarate) | 2251806-70-7 | 98.3% | 329.30 | 1 ML
Pirepemat (IRL752) fumarate is a cognition-promoting agent that preferentially acts on the cortex, affecting catecholamine transmission. It is currently being investigated for its potential use in the treatment of Parkinson's disease.
- A cortical-preferring cognition-promoting agent.
- Used for the study of Parkinson's disease.
- Displays highest in vitro affinities for 5-HT and NA-related targets.
Medchemexpress LLC Monoethyl fumarate | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 | C6H8O4 | 5 G
Monoethyl fumarate is the monoethyl ester of fumaric acid used primarily in research as an activator of the Nrf2 pathway and as a preservative and polymerization agent for macromolecular materials. It is provided as a high-purity solid suitable for biochemical and materials applications.
- Activates the Nrf2 signaling pathway relevant for redox research.
- High purity (≈99.6%), suitable for analytical and research use.
- Solid form with defined storage stability under recommended conditions.
- Useful as a preservative and polymerization agent for macromolecular materials.
- Available in multiple pack sizes and solution formats for flexible use.
Medchemexpress LLC Fumarate hydratase-I 100mg
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Cayman Chemical DImethyl fumarate 25g
A lipophilic electrophile that has profound effects on oxidative and immunological pathways; activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels; suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis
Medchemexpress LLC NS3861 fumarate | 216853-59-7 | 99.8% | 284.22 | 1 ML
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) that binds with high affinity to the heteromeric α3β4 nAChR. It is intended for research use only.
- Selectively activates α3-containing nAChRs.
- Displays higher efficacy at the α3β2 receptor compared to the α3β4 receptor.
- Exhibits high affinity and partial agonist properties in α3β4-expressed nAChRs.
- Appears as an off-white to light yellow solid.
- Soluble in DMSO at 50 mg/mL.
Medchemexpress LLC Ensitrelvir fumarate | 2757470-18-9 | 99.99% | C26H21ClF3N9O6 | 1 ML
Ensitrelvir (S-217622) fumarate is the first orally active, non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor. It demonstrates high potency with an IC50 of 13 nM and is intended for research use only. The compound has shown significant antiviral activity in vitro against various SARS-CoV-2 variants.
- First orally active, non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor.
- Exhibits an IC50 of 13 nM, indicating high potency.
- Effective against wild-type SARS-CoV-2 and Alpha, Beta, Gamma, and Delta variants with EC50 values of approximately 0.4 μM.
- Also active against SARS-CoV and MERS-CoV, with EC50 values of 0.21 and 1.4 μM, respectively.
- Dose-dependently inhibits intrapulmonary replication of SARS-CoV-2 in mice.
Medchemexpress LLC Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1) | 2251806-70-7 | 98.3% | 329.30 | 25 MG
Pirepemat fumarate (IRL752 fumarate) is a cortical-preferring catecholamine- and cognition-promoting agent. It is used for the study of Parkinson's disease and shows high affinities for 5-HT and NA-related targets. It can reverse deficits resulting from hypomonoaminergic function.
- Cortical-preferring catecholamine- and cognition-promoting agent
- Used for the study of Parkinson's disease
- Shows highest in vitro affinities for 5-HT and NA-related targets
- Reverses deficits from hypomonoaminergic function
- White to off-white solid appearance
- Store at 4°C, sealed and away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture