Cycloheptathiophenes
Medchemexpress LLC Ibutilide fumarate | 122647-32-9 | 99.69% | 10 MM 1 ML
Ibutilide fumarate (U70226E) is an action potential-prolonging antiarrhythmic. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Prolongs cardiac repolarization in vitro and in vivo
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone
- Cells expressing MDR1*7 show marked resistance to Ibutilide
Medchemexpress LLC Cevipabulin fumarate | 849550-67-0 | 99.9% | 580.89 | 25 MG
Cevipabulin fumarate is an oral, microtubule-active, antitumor compound that inhibits the binding of [3H]NSC 49842 to tubulin. It exhibits an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines, demonstrating good activity on various cancer cell lines.
- Oral, microtubule-active, antitumor compound
- Inhibits binding of [3H]NSC 49842 to tubulin
- Shows cytotoxicity in human tumor cell lines (IC50 of 18-40 nM)
- Active against ovarian, breast, prostate, and cervical tumors
- Produces sub-G1 nuclei at low concentrations (20-40 nM)
- Causes strong G2-M block at concentrations above 50 nM
- Active in vivo against human tumor xenografts
- Exhibits dose-dependent antitumor activity
- Targets microtubule/tubulin and cell cycle/DNA damage pathways
Medchemexpress LLC Ro 48-8071 | 189197-69-1 | 99.1% | 564.44 | 100 MG
Ro 48-8071 is an inhibitor of Oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It is intended for research use only.
- Inhibits cholesterol synthesis in HepG2 cells (IC50 ~1.5 nM).
- Reduces viability of PC-3 prostate cancer cells, not normal prostate cells.
- Induces apoptosis in LNCaP, C4-2, castration-resistant PC-3, and DU145 cell lines.
- Reduces AR protein expression; increases ERβ protein expression dose-dependently.
- Inhibits 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 ~10 μM).
- Lowers LDL-C by ~60% in hamsters without affecting HDL-C.
- Increases MOS in liver; significantly reduces VLDL secretion in hamsters.
- Reduces in vivo tumor growth in mice without weight loss; can eradicate tumors.
- Sustains and selectively suppresses intestinal cholesterol synthesis in BALB/c mice.
Medchemexpress LLC Tepilamide fumarate | 1208229-58-6 | 99.8% | 243.26 | 50 MG
Tepilamide fumarate is an oral fumaric acid ester that acts as a proagent of Monomethyl fumarate. It is used in the research of moderate to severe chronic plaque psoriasis and can enhance the effectiveness of oncolytic viruses.
- Acts as a proagent of Monomethyl fumarate
- Used in research for moderate to severe chronic plaque psoriasis
- Enhances the effectiveness of oncolytic viruses
- Increases susceptibility of cancer cells to VSV∆51 infection
Medchemexpress LLC Fesoterodine (fumarate) | 286930-03-8 | MFCD09835695 | ≥98% | 574.67 | 10 MG
Fesoterodine fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It is used for the overactive bladder (OAB).
- Orally active
- Nonsubtype selective
- Competitive muscarinic receptor (mAChR) antagonist
- Targets mAChR
- Used for overactive bladder (OAB)
- Research areas include neurological disease, metabolic disease, and cancer
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 50 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent and a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM).
- Cells expressing MDR1*7 show resistance (IC50: 105.3 nM vs 27.4 nM).
- Prolongs cardiac repolarization in vitro and in vivo.
- Cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., 10-min infusion) resulted in polymorphic and monomorphic non-sustained ventricular tachycardia in animal models.
- Increased action potential duration at 90% (APD90) prolongation in congestive heart failure (CHF) dogs compared to controls at 0.01 mg/kg.
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 100 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells, playing a role in cardiac repolarization. This product is suitable for research applications in cardiac physiology and pharmacology.
- Potent IKr blocker
- Prolongs cardiac repolarization
- Relevant for studies on atrial tumor myocytes
- Useful in research related to congestive heart failure models
Medchemexpress LLC Formoterol fumarate | 43229-80-7 | >99.9% | C19H24N2O4 . 1/2C4H4O4 | 100 MG
Formoterol fumarate is a selective β2-adrenoceptor agonist, at least as selective as Salbutamol and Terbutaline. It relaxes acetylcholine-pre-contracted human isolated segmental bronchi and can be used for research related to chronic obstructive pulmonary disease and bronchial asthma.
- Selective β2-adrenoceptor agonist
- Relaxes acetylcholine-pre-contracted human isolated segmental bronchi
- Suitable for research on chronic obstructive pulmonary disease
- Suitable for research on bronchial asthma
Medchemexpress LLC NS3861 fumarate | 216853-59-7 | 99.8% | 284.22 | 1 ML
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) that binds with high affinity to the heteromeric α3β4 nAChR. It is intended for research use only.
- Selectively activates α3-containing nAChRs.
- Displays higher efficacy at the α3β2 receptor compared to the α3β4 receptor.
- Exhibits high affinity and partial agonist properties in α3β4-expressed nAChRs.
- Appears as an off-white to light yellow solid.
- Soluble in DMSO at 50 mg/mL.
Medchemexpress LLC Ketotifen | 34580-13-7 | 99.7% | 10 MM * 1 ML
Ketotifen is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro and also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used for research on autoimmune encephalomyelitis (EAE) and asthma attack prevention.
- Orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer.
- Can block 6-phosphogluconate dehydrogenase (PGD) in vitro.
- Has antiviral activity against SARS-CoV-2 and influenza virus.
- Can be used for research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.
Medchemexpress LLC Ketotifen fumarate | 34580-14-8 | 99.88% | 500 MG
Ketotifen fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. It can block 6-phosphogluconate dehydrogenase (PGD) in vitro and exhibits antiviral activity against SARS-CoV-2 and Influenza virus. It is used in the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.
- Orally active second-generation noncompetitive histamine 1 (H1) receptor blocker
- Mast cell stabilizer
- Blocks 6-phosphogluconate dehydrogenase (PGD) in vitro
- Exhibits antiviral activity against SARS-CoV-2 and Influenza virus
- Used in research for autoimmune encephalomyelitis (EAE)
- Used in research for asthma attack prevention