Lactams
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 g/mol | C15H12N2O7 | 50 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate for the synthesis of PROTAC molecules. Supplied as a solid with supplier-characterized purity, it is intended for research applications in targeted protein degradation.
- Acts as a cereblon ligand for targeted protein degradation research.
- Suitable intermediate for PROTAC synthesis and conjugation chemistry.
- Approximately 95.0% purity, characterized by supplier analytical data.
- Solid form, light yellow to brown appearance for easy handling.
- Good solubility in DMSO for in vitro formulation and assays.
- Stable when stored under recommended conditions for long-term use.
Medchemexpress LLC Thalidomide-5-o-c9-nh2 hydrochloride | 99.6% | 451.94 g·mol⁻1 | C22H30ClN3O5 | 10 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research. Supplied as the hydrochloride salt, it is used as an E3 ligase recruiting moiety in PROTACs and related conjugates. The product is reported with molecular formula C22H30ClN3O5 and molecular weight 451.94 g·mol⁻1.
- High purity: 99.6%.
- Hydrochloride salt form for improved handling and solubility.
- Designed for recruitment of cereblon (CRBN) in PROTAC construction.
- Suitable for synthesis, assay development, and linker conjugation.
- Available in small research pack sizes for laboratory use.
Cayman Chemical ThalIdomIde 5mg
An active enantiomer of (±)-thalidomide; enhances TPA-induced TNF-α production in HL-60 cells from 0.1-100 µM; preincubation of isolated RIR chicken donor blood reduces recipient chicken embryo splenomegaly in a model of graft versus host disease at 10 mg/ml; induces fetal malformations when administered to pregnant female rabbits at 150 mg/kg
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 100 MG
Thalidomide-5-Br is a brominated thalidomide derivative supplied for research use in studies of inflammation, tumor biology, and neurology. It is provided as a solid research reagent; consult lot-specific documentation for analytical details.
- Contains a bromodomain; used as a tool compound in biochemical and pharmacological research.
- Reported purity approximately 98% (see product documentation for lot-specific certificate of analysis).
- Solid, off-white to gray appearance suitable for analytical and synthetic applications.
- Storage recommendations: room temperature for shipping; in solution store at -80°C (2 years) or -20°C (1 year).
- Available in multiple pack sizes including 100 mg.
Medchemexpress LLC Thalidomide-o-amido-C3-COOH | 2308035-51-8 | 98.4% | 417.37 | C19H19N3O8 | 2 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short C3 linker terminating in a carboxylic acid. It is intended for use as a CRBN-recruiting building block in PROTAC synthesis and related targeted protein degradation research.
- used as a cereblon (CRBN) recruiting building block in PROTAC synthesis
- terminates in a carboxylic acid for conjugation to target ligands
- reported purity 98.43% by LCMS
- molecular weight 417.37; formula C19H19N3O8
- storage: 4°C under nitrogen; in solution store at -80°C (6 months) or -20°C (1 month)
Apexbio Technology LLC Sulbactam 68373-14-8 10mM (in 1mL DMSO)
Sulbactam (CAS 68373-14-8) is a small-molecule inhibitor targeting bacterial -lactamase enzymes It is designed to inhibit -lactamase-mediated hydrolytic inactivation of -lactam antibiotics thereby enhancing antibiotic stability and efficacy Sulbactam exerts its biological activity primarily through competitive irreversible inhibition by covalently binding to the -lactamase active site Experimental studies report an IC50 value in the low micromolar range for inhibition of various bacterial -lactamase enzymes Based on these pharmacological properties Sulbactam holds research potential in investigating resistance mechanisms to -lactam antibiotics assessing combined therapeutic regimens and exploring novel clinical strategies for infections caused by -lactamase-producing pathogens
Medchemexpress LLC Thalidomide-4-o-c2-nh2 hydrochloride | 2341840-99-9 | 99.4% | 353.76 | 50 MG
Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Utilizes a linker used in PROTAC technology
- For research use only
Cayman Chemical AzIdo-ThalIdomIde 5mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-5-PEG7-NH2 hydrochloride | 618.07 g/mol | C27H40ClN3O11 | 10 MG
Thalidomide-5-PEG7-NH2 hydrochloride is a thalidomide-derived cereblon ligand with a PEG7 spacer provided as the hydrochloride salt. It is designed for use as an E3 ligase ligand in PROTAC and ligand-linker conjugate synthesis and is supplied as a solid for research applications.
- Thalidomide-derived cereblon ligand for recruitment of CRBN.
- PEG7 spacer offers a flexible linker for conjugation to target ligands.
- Provided as the hydrochloride salt to aid handling and solubility.
- White to off-white solid physical form.
- Molecular formula C27H40ClN3O11 and molecular weight 618.07 g/mol.
- Store sealed at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month.
- Available in small mg quantities for laboratory research use.
Medchemexpress LLC Tz-thalidomide (tetrazine tagged thalidomide) | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 50 MG
Tz-thalidomide is a tetrazine-tagged derivative of thalidomide designed for research applications in click chemistry and targeted protein degradation. It is supplied as a pink to red solid with high purity and is formulated for solubility in DMSO for in vitro use.
- Tetrazine-functionalized thalidomide scaffold for iEDDA click reactions.
- High purity (98.6%) suitable for biochemical assays.
- Solid, pink to red form that is stable under recommended storage conditions.
- Good solubility in DMSO (50 mg/mL) for stock preparation.
- Available in small research quantities compatible with probe synthesis.
- Applicable as an E3 ligase ligand for PROTAC and molecular-glue studies.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.