Lactams
Medchemexpress LLC Tert-butyl (4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)carbamate | 2093388-52-2 | MFCD32671351 | 99.6% | C22H28N4O6 | 10MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide core with a Boc-protected C4 amine linker for use in PROTAC synthesis and related chemical biology applications requiring targeted E3 ligase recruitment.
- Boc-protected C4 amine linker enables selective deprotection and conjugation.
- Cereblon-binding thalidomide core suitable for E3 ligase recruitment.
- High purity (99.6%) for reliable synthetic and analytical results.
- Available in multiple sizes for small-scale and larger syntheses.
- Solid, yellow to green appearance; stable when stored protected from light.
Medchemexpress LLC Thalidomide-o-amido-c3-peg3-c1-nh2 trifluoroacetate | 1799711-29-7 | MFCD32878273 | 99.1% | C27H35F3N4O11 | 10MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that couples a thalidomide-derived cereblon ligand to a three-unit polyethylene glycol linker, designed for PROTAC synthesis and related chemical biology research. The compound is supplied as an off-white to light yellow oil, with molecular formula C27H35F3N4O11, molecular weight 648.58 g·mol⁻¹, and high purity suitable for research.
- Contains a thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Includes a three-unit polyethylene glycol linker to enhance flexibility and solubility.
- Designed for PROTAC design and targeted protein degradation studies.
- High purity (99.1%) for consistent experimental results.
- Characterized molecular properties facilitate reproducible use in research.
- Available in small packaging sizes suitable for laboratory studies.
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 95.6% | 465.97 | C23H32ClN3O5 | 5 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand provided as a hydrochloride salt for use in PROTAC construction and chemical biology research. Supplied as a research reagent, it is intended for laboratory applications and not for human use.
- Cereblon ligand suitable for E3 ligase recruitment in PROTACs and degrader design.
- Hydrochloride salt improves solubility and handling compared with the free base.
- Reported purity approximately 95.6% as supplied.
- Molecular formula C23H32ClN3O5 and molecular weight 465.97.
- Available in small research pack sizes, for example 5 mg.
Research Products International Corp Aztreonam, 100 MG
Aztreonam is a synthetic monocyclic beta-lactam antibiotic, with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum.
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide-O-PEG4-amine (hydrochloride) | 2820929-03-9 | C23H32ClN3O9 | 50 MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates thalidomide based cereblon ligand
- Uses a linker in PROTAC technology
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG
Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.
- Provides a cereblon-binding ligand for CRBN-mediated degradation
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
- PEG3 spacer improves solubility and linker flexibility
- Terminal carboxylic acid enables amide coupling and conjugation
- Supplied at research-grade purity suitable for synthesis
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 50 MG
Thalidomide-O-C8-Boc is a thalidomide-based cereblon ligand that is used to recruit the CRBN protein. It can be linked to a protein ligand by a linker to create PROTACs. This product is intended for research use only.
- Functions as a thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon