Lactams
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Thalidomide-piperazine-PEG2-NH2 diTFA | 00-00-0 | 99.7% | C27H33F6N5O10 | 10MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-derived cereblon (CRBN) ligand and a PEG2-piperazine amino linker. Supplied as the bis(trifluoroacetate) salt, it is designed as a building block for assembling heterobifunctional degraders (PROTACs) to recruit CRBN and enable targeted protein degradation.
- Incorporates thalidomide-based cereblon ligand for CRBN recruitment.
- Contains a PEG2-piperazine linker with a terminal primary amine for conjugation chemistry.
- Supplied as the bis(trifluoroacetate) salt to aid handling and solubility.
- High purity suitable for synthesis (99.7%).
- Water solubility up to 50 mg/mL with ultrasonic assistance.
- Store sealed at 4°C, away from moisture.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | 96.3% | C23H24N2O9 | 10MG
Thalidomide-Propargyne-PEG3-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate featuring a terminal propargyl alkyne and a PEG3 spacer terminating in a carboxylic acid. It is intended as a research reagent for chemical biology and PROTAC synthesis to enable cereblon recruitment and bioorthogonal conjugation in degradation studies.
- Provides a cereblon-binding ligand for CRBN-mediated degradation
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition
- PEG3 spacer improves solubility and linker flexibility
- Terminal carboxylic acid enables amide coupling and conjugation
- Supplied at research-grade purity suitable for synthesis
Medchemexpress LLC Thalidomide-O-PEG4-Boc | 2411681-87-1 | C28H38N2O11 | 25MG
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Incorporates thalidomide-based cereblon ligand.
- Utilizes a linker in PROTAC technology.
- Contains two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase, and the other is for the target protein.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | C17H20ClN3O5 | 10MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a C4 amine-containing linker for use in PROTAC development and targeted protein degradation research. Supplied as a hydrochloride salt and intended for research use only.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for biochemical and cell-based assays.
- Molecular formula C17H20ClN3O5; molecular weight 381.81 g·mol⁻¹.
- Available in small milligram quantities for discovery research.
- Storage: sealed at 4°C; in solution, -80°C for long-term storage.
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Cayman Chemical AzIdo-ThalIdomIde 25mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
eMolecules 28562-58-5 | 4-Benzoyloxy-2-azetidinone | Combi-Blocks | MFCD00012317 | 191.186 | C10H9NO3 | 97.000 | O=C(OC1CC(=O)N1)c1ccccc1 | 5g | 267200513
4-Benzoyloxy-2-azetidinone | Combi-Blocks | 28562-58-5 | MFCD00012317 | 191.186 | C10H9NO3 | 97.000 | O=C(OC1CC(=O)N1)c1ccccc1 | 5g | 267200513
eMolecules 17557-84-5 | 3-Azetidinone hydrochloride | Synthonix - Stock | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 1g | 525905203
3-Azetidinone hydrochloride | Synthonix - Stock | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 1g | 525905203
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524