Lactams
Medchemexpress LLC CD3 epsilon Canine 100ug | 100ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC CD23/Fc epsilon RII 50ug
CD23/Fc epsilon RII Protein a low-affinity receptor for IgE and CR2/CD21 regulates IgE production and B cell differentiation On B cells it initiates IgE-dependent antigen uptake and presentation to T cells On macrophages IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding CD23/Fc epsilon RII Protein Mouse (HEK293 His) is the recombinant mouse-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-His labeled tag
Medchemexpress LLC CD3 epsilon Canine 10ug | 10ug
The CD3 protein on lymphocytes is a component of the TCR-CD3 complex and is critical for adaptive immune responses When APC is activated TCR signals transmitted by CD3D CD3E CD3G and CD3Z initiate pathways through ITAM CD3 epsilon Protein Canine (HEK293 Fc) is the recombinant canine-derived CD3 epsilon protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC CD3 epsilon Human 500ug
Recombinant human CD3 epsilon protein produced in HEK293 mammalian cells and supplied as a lyophilized preparation with a C-terminal 6xHis tag, intended for research use in studies of T-cell receptor signaling, binding assays, and related immunological applications. Lot-specific COA provides detailed formulation and buffer information.
- Produced in HEK293 mammalian expression system.
- C-terminal 6xHis tag for detection and purification.
- Lyophilized powder formulation for convenient storage and handling.
- Approximate molecular weight 18-21 kDa by SDS-PAGE.
- Stable at -20 °C for long-term storage; reconstituted stability at 4 °C for one week.
- Lot-specific COA and datasheet available for quality and formulation details.
Medchemexpress LLC Thalidomide-5-O-C13-NH2 hydrochloride | 99.9% | 508.05 g/mol | C26H38ClN3O5 | 10 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation. It is intended for conjugation to target-binding ligands via linkers for PROTAC design and other bifunctional degrader constructs.
- High purity suitable for research assays (approximately 99.9%).
- Hydrochloride salt form for improved stability and handling.
- Compatible with linker conjugation for PROTAC synthesis.
- Recommended storage at -20°C; protect from light and oxygen.
- Supplied in small milligram quantities for exploratory studies.
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.6% | 380.78 | 50 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands via a linker to form PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Connects to ligands for protein by a linker to form PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 10 mM * 1 mL in DMSO Solution
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
Medchemexpress LLC Tert-butyl (4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)carbamate | 2093388-52-2 | MFCD32671351 | 99.6% | C22H28N4O6 | 10MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide core with a Boc-protected C4 amine linker for use in PROTAC synthesis and related chemical biology applications requiring targeted E3 ligase recruitment.
- Boc-protected C4 amine linker enables selective deprotection and conjugation.
- Cereblon-binding thalidomide core suitable for E3 ligase recruitment.
- High purity (99.6%) for reliable synthetic and analytical results.
- Available in multiple sizes for small-scale and larger syntheses.
- Solid, yellow to green appearance; stable when stored protected from light.
Medchemexpress LLC CD23/Fc epsilon RII 10ug
CD23 also known as Fc epsilon Receptor II (Fc epsilon RII) is a low-affinity receptor for immunoglobulin E (IgE) and complement receptor 2 (CR2/CD21) CD23 regulates IgE production and B-cell differentiation aiding in IGE-dependent antigen uptake CD23/Fc epsilon RII Protein Rat (HEK293 Fc) is the recombinant rat-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-hFc labeled tag
Medchemexpress LLC NFKBIE/IKB epsilon protein, human (His tag) | 50UG
Recombinant human NFKBIE (IκBε) protein with a His tag, expressed in E. coli and supplied lyophilized for in vitro biochemical and cell-signaling studies of NF-κB regulation. Lyophilized material is provided from a buffered formulation and is stable when stored at recommended temperatures.
- Recombinant human NFKB inhibitor epsilon with a His tag
- Expressed in E. coli and purified for research use
- Sequence length 395 amino acids and approximate mass 57 kDa
- Lyophilized from 50 mM Tris-HCl, 200 mM NaCl, 200 mM arginine, pH 8.0, 10% glycerol
- Store frozen; stable at -20°C for long term and at 4°C for short term after reconstitution
Selleck Chemical LLC Thalidomide S1193-1g
Thalidomide was introduced as a sedative drug immunomodulatory agent and also is investigated for treating symptoms of many cancers Thalidomide inhibits cereblon (CRBN) a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1
Medchemexpress LLC Aztreonam | 78110-38-0 | 99.6% | 200 MG
Aztreonam (SQ-26,776) is a synthetic monocyclic beta-lactam antibiotic that exhibits a very high affinity for penicillin-binding protein 3 (PBP-3). It functions by inhibiting mucopeptide synthesis within the bacterial cell wall, thereby preventing peptidoglycan crosslinking. While resistant to some beta-lactamases, it is inactivated by extended-spectrum beta-lactamases. Aztreonam demonstrates no useful activity against gram-positive or anaerobic microorganisms.
- Inhibits mucopeptide synthesis in bacterial cell walls
- Blocks peptidoglycan crosslinking
- High affinity for penicillin-binding protein 3 (PBP-3)
- Resistant to certain beta-lactamases
- Bactericidal properties
