Lactams
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | C22H26N2O7 | 10MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon (CRBN) ligand supplied as a solid research reagent for use in PROTAC design and chemical biology studies. It has molecular formula C22H26N2O7, molecular weight 430.45 g/mol, and a reported purity of 97.44%.
- Used as a cereblon E3 ligase recruiting moiety in PROTAC synthesis.
- White to off-white solid suitable for laboratory handling.
- Reported purity of 97.4% for research applications.
- Storage guidance provided for long-term and in-solvent conditions.
- Available in small research quantities for assay development.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-piperazine-PEG1-COOH | 2731007-11-5 | 99.2% | 458.46 | 25 MG
Thalidomide-Piperazine-PEG1-COOH is a synthetic E3 ligase ligand-linker coupler containing a Thalidomide-based ligand and one linker. It acts as an E3 ligase ligand-linker conjugate.
- E3 ligase ligand-linker coupler
- Contains a Thalidomide-based ligand and one linker
Medchemexpress LLC Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | 99.9% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Thalidomide-NH-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) construction and related chemical biology research. Provided as a light yellow solid with high purity and defined storage stability, it is intended for laboratory research use only.
- High purity (99.85%) suitable for research applications.
- Hydrochloride salt form to aid handling and solubility considerations.
- Available in small research pack sizes, including 10 mg, for synthesis workflows.
- Designed to act as a CRBN-binding E3 ligase ligand in PROTAC constructs.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (trifluoroacetate) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 50 MG
Thalidomide-O-amido-C4-NH2 (trifluoroacetate) is a thalidomide-derived cereblon ligand supplied as the TFA salt for use as an E3 ligase ligand/linker building block in PROTAC and chemical biology research.
- Provided as the trifluoroacetate salt.
- High purity (99.9%, LCMS).
- Molecular weight 516.42 g/mol.
- CAS number 1799711-25-3.
- Appearance: solid, white to off-white.
- Packaged as a 50 MG quantity.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g·mol⁻¹ | C21H23F3N4O8 | 2 G
Thalidomide-O-amido-C4-NH2 TFA is a thalidomide-derived cereblon ligand-linker conjugate provided as the trifluoroacetate (TFA) salt for use in PROTAC design and other chemical biology applications. It is supplied as a white to off-white solid with high analytical purity and a molecular weight of 516.42 g·mol⁻¹.
- Thalidomide-derived cereblon ligand-linker conjugate.
- Provided as the trifluoroacetate (TFA) salt.
- High purity by LCMS (reported 99.92%).
- White to off-white solid appearance.
- Molecular formula C21H23F3N4O8; molecular weight 516.42 g·mol⁻¹.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Thalidomide-5-PEG4-NH2 hydrochloride | 2743434-24-2 | 95.2% | 485.92 g/mol | C21H28ClN3O8 | 5 MG
Thalidomide-5-PEG4-NH2 hydrochloride is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide moiety with a four-unit PEG linker. It is intended as a research reagent for PROTAC design and targeted protein degradation studies and is supplied as a light yellow to yellow oil with reported high purity.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC synthesis.
- Contains a cereblon-binding thalidomide moiety with a PEG4 linker for linker flexibility.
- High reported purity suitable for research applications (95.2%).
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Light yellow to yellow oil; easy to handle in synthetic workflows.
- Store sealed away from moisture; recommended storage at -20°C (in solvent: -80°C for long term).
Medchemexpress LLC Thalidomide-5 6-F 1g
Thalidomide-5 6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein Thalidomide-5 6-F can be connected to the ligand for protein by a linker to form PROTACs[1]
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | 486.56 g·mol⁻¹ | C26H34N2O7 | 5 MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand for targeted protein degradation research. It is designed to be connected to a protein-targeting ligand via a linker to form PROTAC molecules and is provided as a research-grade chemical with manufacturer-reported purity (~95.1%).
- Acts as a cereblon ligand to recruit CRBN.
- Designed for conjugation via a linker to form PROTACs.
- Supplied at research-grade purity (~95.1%).
- Molecular formula C26H34N2O7; molecular weight 486.56 g·mol⁻¹.
- Available in milligram-scale quantities suitable for synthesis and screening.
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 2 MG
Thalidomide-propargyl is a Cereblon ligand derived from Thalidomide that facilitates the recruitment of the CRBN protein. It can be linked to other ligands to form IMiD-containing PROTACs. This compound is a click chemistry reagent, featuring an Alkyne group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Can be connected to ligands for protein to form IMiD containing PROTACs.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 50 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. This product is intended for research use only and for experienced personnel in appropriately equipped facilities.
- Incorporates Thalidomide-based cereblon ligand
- Features a 2-unit PEG linker
- Used in PROTAC technology
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Identified as laboratory chemicals for substance manufacture
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | C21H20N2O8 | 10MG
Thalidomide-Propargyne-PEG2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate designed for use in PROTAC development and bioconjugation workflows. It incorporates a CRBN-binding thalidomide core, a short PEG2 spacer, and a terminal propargyne for click chemistry; supplied as a solid with high reported purity and good DMSO solubility.
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | >95.0% | C30H44Cl2FN5O5S | 10MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von Hippel-Lindau (VHL) protein ligand developed as a building block for PROTAC synthesis and E3 ligase conjugation. Supplied as the dihydrochloride salt, it is intended for research use in targeted protein degradation and conjugation workflows.
- VHL ligand suitable for PROTAC synthesis and E3 ligase recruitment.
- Dihydrochloride salt for improved handling and conjugation chemistry.
- Molecular formula C30H44Cl2FN5O5S; molecular weight 676.67 g/mol.
- Purity reported as ≥95.0% by HPLC in supplier documentation.
- Recommended storage: keep dry at room temperature; in solvent store at -80°C (2 years) or -20°C (1 year).
- Intended for research use in targeted protein degradation and conjugation workflows.
Medchemexpress LLC Thalidomide-5-NH2-C8-NH2 (TFA) | 2097509-49-2 | 514.49 g/mol | C23H29F3N4O6 | 10 MG
Thalidomide-5-NH2-C8-NH2 (TFA) is a thalidomide-derived intermediate provided as the trifluoroacetic acid salt for research use and compound synthesis. It is intended for laboratory applications only and should be handled using appropriate safety procedures; store sealed at -20°C away from moisture and light. In solvent, recommended storage is -80°C for up to 6 months or -20°C for up to 1 month.
- Salt form: trifluoroacetic acid (TFA) salt.
- Suitable for compound synthesis and as a building block.
- Molecular formula: C23H29F3N4O6.
- Molecular weight: 514.49 g/mol.
- Storage: sealed at -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or clinical use.