Lactams
Medchemexpress LLC Thalidomide-1-me,4-oh | 2244568-06-5 | ≥98.0% | 288.26 g·mol-1 | C14H12N2O5 | 100 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and an N-1 methyl group. It serves as a cereblon/E3 ligase ligand scaffold for research into ubiquitin-mediated proteolysis and is supplied as a solid research reagent.
- Small-molecule cereblon/E3 ligase ligand used in biochemical and cell-based assays
- High purity suitable for research applications
- Powder form with defined storage recommendations for long-term stability
- Includes chemical identifiers for traceability, including CAS and molecular formula
- Applicable for studies of targeted protein degradation and ligand design
![eMolecules Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502457212.PNG-250.jpg)
eMolecules Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5
Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 250 MG
Thalidomide-pinacolborane is a thalidomide analogue that incorporates a boronic pinacol ester (Bpin). It is used as a synthetic intermediate for cross-coupling chemistry and as an E3 ligase (cereblon) ligand in chemical biology and targeted protein degradation research.
- Contains a boronic pinacol ester suitable for Suzuki-Miyaura cross-coupling.
- Functions as an E3 ligase (cereblon) ligand for PROTAC and degradation studies.
- High purity appropriate for research applications.
- Available in research-scale quantities for assay development.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g/mol.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 g/mol | C13H9IN2O4 | 250 MG
Thalidomide-iodo is an iodinated derivative of thalidomide that functions as an E3 ligase activator for chemical biology and medicinal chemistry research. It is supplied as a solid research reagent and can be used as a synthetic building block for further derivatization via substitution of the iodine atom.
- Iodinated thalidomide derivative suitable for E3 ligase activation studies.
- Useful as a synthetic building block for iodine substitution and derivatization.
- High purity (≥98.0%) appropriate for research applications.
- Molecular weight 384.13 g/mol; formula C13H9IN2O4.
- CAS number 2509137-01-1 for unambiguous identification.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | C22H27N3O9 | 5 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a carboxylic acid. It is intended as a modular building block for PROTAC development to recruit CRBN and enable linker attachment to target-binding ligands.
- Designed for PROTAC assembly and CRBN recruitment.
- Contains a PEG3 linker terminating in a carboxylic acid for facile conjugation.
- Incorporates a thalidomide-based cereblon ligand.
- High chemical purity (≈98.9%).
- Suitable for medicinal chemistry and chemical biology applications.
![eMolecules AstaTech / 4-BENZOYLOXY-2-AZETIDINONE / 1g / 718073279 / D88798 / 95.000 / 28562-58-5 / [null] / 191.186 / C10H9NO3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502451704.PNG-250.jpg)
eMolecules AstaTech / 4-BENZOYLOXY-2-AZETIDINONE / 1g / 718073279 / D88798 / 95.000 / 28562-58-5 / [null] / 191.186 / C10H9NO3
AstaTech / 4-BENZOYLOXY-2-AZETIDINONE / 1g / 718073279 / D88798 / 95.000 / 28562-58-5 / [null] / 191.186 / C10H9NO3
eMolecules Thalidomide-Acid | 1061605-21-7 | | 1g
Broadpharm | Thalidomide-Acid | 1g | 550804650 | BP-24447 | 98.000 | 1061605-21-7 | | 332.268 | C15H12N2O7
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Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | MFCD34186095 | 95.0% | 332.26 g/mol | C15H12N2O7 | 50 MG
Thalidomide-5-O-CH2-COOH is an E3 ligase ligand-linker conjugate used as a cereblon (CRBN) ligand and an intermediate for the synthesis of PROTAC molecules. Supplied as a solid with supplier-characterized purity, it is intended for research applications in targeted protein degradation.
- Acts as a cereblon ligand for targeted protein degradation research.
- Suitable intermediate for PROTAC synthesis and conjugation chemistry.
- Approximately 95.0% purity, characterized by supplier analytical data.
- Solid form, light yellow to brown appearance for easy handling.
- Good solubility in DMSO for in vitro formulation and assays.
- Stable when stored under recommended conditions for long-term use.