Lactams
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC CD3 epsilon 1-27 pep 50ug | 50ug
CD3 epsilon is an important component of the TCR-CD3 complex on T lymphocytes and promotes TCR-mediated signaling When APC activates the TCR CD3 epsilon together with CD3D CD3G and CD3Z transmits signals across the cell membrane through ITAMs CD3 epsilon 1-27 peptide Protein Human (Biotinylated HEK293 hFc-Avi) is the recombinant human-derived CD3 epsilon 1-27 peptide protein expressed by HEK293 with C-Avi C-hFc labeled tag
Selleck Chemical LLC Tazobactam Sodium-E0167-5MG
Tazobactam (Tazobactam acid Tazobactamum) Sodium is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms
Sigma Aldrich Fine Chemicals Biosciences 7-Aminodesacetoxycephalosporanic acid European Pharmacopoeia (EP) Reference Standard | 22252-43-3 | MFCD09750368 |
7-Aminodesacetoxycephalosporanic acid European Pharmacopoeia (EP) Reference Standard | Mol Wt: 214.24 | 22252-43-3 | MFCD09750368 |
Sigma Aldrich Fine Chemicals Biosciences 7-Aminodesacetoxycephalosporanic acid | 22252-43-3 | MFCD09750368 | 1G
7-Aminodesacetoxycephalosporanic acid | Mol Wt: 214.24 | 22252-43-3 | MFCD09750368 | 1G
Medchemexpress LLC 4-(2-aminoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | 2341840-99-9 | MFCD32705128 | 99.4% | C15H16ClN3O5 | 10MG
Thalidomide-4-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) research. It pairs a thalidomide-based CRBN-binding moiety with a short C2 aminoalkyl linker to enable conjugation to target ligands and recruitment of the E3 ubiquitin ligase for targeted protein degradation.
- Designed to recruit cereblon E3 ligase in PROTAC constructs.
- Short C2 aminoalkyl linker enables close proximity between ligand and E3 ligase.
- Supplied as hydrochloride salt for improved stability and handling.
- Characterized by analytical data, including H NMR and LC-MS.
- High purity suitable for research applications.
- Intended for research use only; not for human therapeutic use.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | C25H36ClN5O9 | 10MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a thalidomide-based cereblon (CRBN) ligand-linker conjugate intended as a building block for PROTAC synthesis. The molecule combines a thalidomide-derived CRBN recruiting moiety with an amino-terminated PEG4-C2 spacer to enable straightforward coupling to target ligands. It is supplied as the hydrochloride salt for improved handling and is for research use only.
- High HPLC purity (98.0%).
- Amino-terminated PEG4-C2 linker for facile conjugation.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- Supplied as a solid hydrochloride salt, light yellow to yellow.
- Available in small-scale quantities suitable for medicinal chemistry.
- Store sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC N-(2-amino-5-(thiophen-2-yl)phenyl)-2-(piperazin-1-yl)quinoline-6-carboxamide | 1609389-52-7 | MFCD30342405 | 99.6% | 429.54 g·mol⁻¹ | C24H23N5OS | 25 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2 used in preclinical research. It potently inhibits HDAC1 (IC50 = 7 nM) and HDAC2 (IC50 = 18 nM), with substantially weaker activity against HDAC3 (IC50 = 1,300 nM), and shows no significant inhibition of HDAC4-HDAC9. The compound is provided as a purified research reagent for biochemical and cellular studies of epigenetic regulation.
- Potent HDAC1 inhibition (IC50 = 7 nM).
- Selective for HDAC1/2 over HDAC3 (IC50 HDAC2 = 18 nM; HDAC3 = 1,300 nM).
- Orally active profile reported in preclinical studies.
- Suitable for biochemical and cellular assays investigating epigenetic regulation.
- High chemical purity for reproducible experimental results.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | MFCD35061671; MFCD32068377 | 97.9% | C19H24ClN3O7 | 10MG
Thalidomide-5-PEG3-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate supplied as the hydrochloride salt. It is intended for research use in PROTAC development and E3 ligase recruitment studies, providing a PEG3 linker terminating in a primary amine for convenient conjugation to target ligands.
- Hydrochloride salt for improved stability and handling.
- PEG3 linker with terminal primary amine for conjugation.
- Cereblon (CRBN) ligand suitable for E3 ligase recruitment in PROTACs.
- High purity appropriate for research synthesis and assays.
- Available in small pack sizes for synthetic workflows.
Medchemexpress LLC (R)-(+)-thalidomide | 260939 | MFCD00210220 | 99.8% | C13H10N2O4 | 10MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied for research use. It is reported to have psychomotor stabilizing properties and is used as a ligand in studies of cereblon-mediated E3 ligase interactions and related cellular pathways. Provided as a high-purity research chemical for biochemical and cellular assays.
- R-enantiomer of thalidomide for stereospecific studies.
- High purity 99.8% suitable for analytical and biological assays.
- Useful for research on cereblon and E3 ligase interactions.
- Available in milligram scales for laboratory research.
- For research use only; not for human or clinical use.
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38