Lactams
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 10g | 410156346
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 10g | 410156346
eMolecules 28562-58-5 | 4-Benzoyloxy-2-azetidinone | Combi-Blocks | MFCD00012317 | 191.186 | C10H9NO3 | 97.000 | O=C(OC1CC(=O)N1)c1ccccc1 | 1g | 267200512
4-Benzoyloxy-2-azetidinone | Combi-Blocks | 28562-58-5 | MFCD00012317 | 191.186 | C10H9NO3 | 97.000 | O=C(OC1CC(=O)N1)c1ccccc1 | 1g | 267200512
![eMolecules [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502160039.JPG-250.jpg)
eMolecules [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | 1g
Pharmablock | [cis-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methanol | 1g | 551294267 | PBU4956 | 285.503 | C15H31NO2Si
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eMolecules Building Block Tool
eMolecules 17557-84-5 | 3-Azetidinone HCl | Ambeed | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 100g | 525113619
3-Azetidinone HCl | Ambeed | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 100g | 525113619
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262032.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG3 spacer terminating in a carboxylic acid. It is designed as a building block for PROTAC and targeted protein degradation research, supplied as a solid with high reported purity and DMSO solubility.
- Incorporates cereblon-binding thalidomide scaffold for E3 recruitment.
- PEG3 linker provides a flexible spacer for target engagement.
- Terminal carboxylic acid enables amide coupling and conjugation chemistry.
- High reported purity (96.95%) suitable for synthesis and analytical work.
- Soluble in DMSO for straightforward stock solution preparation.
- Available in small laboratory pack sizes for research use.
Cayman Chemical AzIdo-ThalIdomIde 50mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | 99.6% | 660.67 g/mol | C23H30F3N5O9 | 25 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a trifluoroacetate salt E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker for use in PROTAC synthesis and related chemical biology research. It is supplied as a high-purity solid and is intended for research use only.
- Contains a thalidomide-based cereblon ligand for cereblon-mediated degradation studies.
- PEG3 linker provides flexibility and solubility for linker optimization in PROTAC design.
- Offered as a solid TFA salt for convenient handling and storage.
- High purity suitable for synthetic chemistry and biological probe development.
- Recommended storage: powder at -20°C; in solution, store at -80°C for long-term preservation.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.
- Provides a cereblon-binding thalidomide ligand for PROTAC design.
- Includes a PEG3 linker to improve solubility and flexibility.
- Features a C2 amine handle for facile coupling to warheads.
- Offered as the TFA salt to aid handling and stability.
- Supplied at high purity (>98%) suitable for synthetic use.
- Available in small research-scale quantities for method development.
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | MFCD00210219 | 99.52% | 258.23 | 50 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- It is the S-enantiomer of thalidomide.
- It exhibits immunomodulatory effects.
- It has anti-inflammatory properties.
- It shows antiangiogenic effects.
- It possesses pro-apoptotic effects.
- It binds to cereblon (CRBN).
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 | 100 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate, incorporating the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This click chemistry reagent contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is designed for research applications related to PROTACs, which utilize the ubiquitin-proteasome system to degrade target proteins.
- Incorporates cereblon ligand and a linker for PROTAC technology
- Click chemistry reagent with an Azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Designed for research in protein degradation via PROTACs
Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.
- Purity: 99.83%
- Molecular weight: 276.22
- Formula: C13H9FN2O4
- CAS No.: 835616-60-9
- Appearance: Solid
- Color: Off-white to gray
- Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon