Oxazinanes
Medchemexpress LLC HADA hydrochloride | 2253733-10-5 | 98.0% | 250 MG
HADA hydrochloride is a blue fluorescent D-amino acid that is efficiently incorporated into the peptidoglycans of diverse bacterial species at the sites of peptidoglycan biosynthesis. This allows for specific and covalent probing of bacterial growth with minimal perturbation.
- Blue fluorescent D-amino acid (λem~450 nm)
- Efficiently incorporated into peptidoglycans of diverse bacterial species
- Allows specific and covalent probing of bacterial growth
- Causes minimal perturbation to bacterial growth
Medchemexpress LLC CN128 hydrochloride | 1335282-05-7 | 98.2% | 250 MG
CN128 hydrochloride (CN328) is an orally active and selective iron chelator primarily used in the research of β-thalassemia. It demonstrates high selectivity for iron(III) over other metals and has been shown to lack genetic toxicity.
- Orally active and selective iron chelator
- Used for research of β-thalassemia
- Exhibits high selectivity for iron(III) over other metals
- Lacks genetic toxicity
- Demonstrates good oral bioavailability (82.6%) in rats
- Well-tolerated in rats with no mortality at higher dose levels
- Shows good iron scavenging efficacy in rats
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | MFCD00891665 | 314.17 | C9H17Cl2N5O3 | 10 MG
Sapropterin dihydrochloride is the dihydrochloride salt of sapropterin ((6R)-BH4), supplied for research use as a PAH cofactor and analytical standard for studies of phenylketonuria and phenylalanine metabolism. It is provided as a solid and is intended for in vitro and analytical applications.
- Dihydrochloride salt form for improved handling and stability.
- Used as a cofactor in phenylalanine hydroxylase studies.
- Suitable for phenylketonuria and metabolic pathway research.
- Molecular formula C9H17Cl2N5O3; molecular weight 314.17 g/mol.
- Available in small research pack sizes suitable for assay and analytical work.
Medchemexpress LLC Iadademstat dihydrochloride | 1431303-72-8 | 99.9% | 50 MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It shows high selectivity for KDM1A and potent cellular activity in acute myeloid leukemia (AML) cell lines. This inhibitor induces the Cd11b differentiation marker and reduces AML tumor growth, enhancing survival in T-ALL models.
- Inhibits KDM1A by irreversible binding to the FAD cofactor.
- Highly selective for KDM1A over MAO enzymes and KDM1B.
- Potent cellular activity in differentiation and colony formation assays on MLL-translocated AML cell lines.
- Induces Cd11b differentiation marker in MLL-AF9 cells.
- Reduces AML tumor growth in mice and rat xenografts.
- Increases survival time in a disseminated model of T-ALL.
Medchemexpress LLC (6S)-CP-470711 | 300552-09-4 | 98.8% | 358.44 | C18H26N6O2 | 10 MG
(6S)-CP-470711 is a research-grade small-molecule inhibitor of sorbitol dehydrogenase (SDH). Supplied as a powder in small research pack sizes, it has low-nanomolar potency against human and rat SDH and is intended for laboratory research use.
- Low-nanomolar SDH inhibitor (human IC50 19 nM; rat IC50 27 nM).
- Powder form suitable for storage and handling.
- Purity 98.75% by manufacturer specification.
- Chemical formula C18H26N6O2; molecular weight 358.44.
- Available in small pack sizes, including a 10 mg pack.
- Storage: powder -20°C for up to 3 years; in solvent -80°C for up to 6 months.
Medchemexpress LLC (6S,12aR)-Tadalafil (Tadalafil EP Impurity C) | 171596-28-4 | 99.5% | C22H19N3O4 | 25 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM, known for its blood pressure lowering activity. This product is intended for research use only and presents as a white to off-white solid.
- Highly potent PDE5 inhibitor with an IC50 value of 5 nM
- Exhibits blood pressure lowering activity
- Supplied as a white to off-white solid
- Soluble in DMSO at 100 mg/mL
- Formulations available for in vivo studies
Medchemexpress LLC Pirenzepine dihydrochloride | 29868-97-1 | 99.8% | 424.32 | 1 G
Pirenzepine dihydrochloride is a selective M1 muscarinic acetylcholine receptor antagonist that poorly penetrates the blood-brain barrier. It is used in peptic ulcer research due to its ability to reduce gastric acid secretion and muscle spasm. This compound also exhibits anti-proliferative activity against cancer cells.
- Selective M1 muscarinic acetylcholine receptor antagonist.
- Reduces gastric acid secretion.
- Reduces muscle spasm.
- Useful in peptic ulcer research.
- Exhibits anti-proliferative activity against cancer cells.
Medchemexpress LLC Fulvestrant-3-boronic acid | 1853279-29-4 | 99.7% | 634.59 | 1 MG
Fulvestrant-3-boronic acid is an orally active ERα inhibitor that competitively binds to ERα (IC50 = 4.1 nM) and effectively degrades ERα in breast cancer cells.
- Orally active ERα inhibitor
- Competitively binds to ERα (IC50 = 4.1 nM)
- Effectively degrades ERα in breast cancer cells
Medchemexpress LLC (2-Phenylquinolin-7-yl)methanol | 361457-37-6 | C16H13NO | 250 MG
(2-Phenylquinolin-7-yl)methanol is a drug intermediate used for the synthesis of various active compounds.
- Drug intermediate for synthesis
- Suitable for various active compounds
Medchemexpress LLC Mirodenafil dihydrochloride | 862189-96-6 | 99.1% | 604.59 | 1 ML
Mirodenafil dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. It also functions as a glucocorticoid receptor (GR) modulator and activates the Wnt/β-catenin signaling pathway. It is used in research for conditions such as erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
- Exerts neuroprotective functions by activating the cGMP/PKG/CREB signaling pathway.
- Enhances neuronal survival by protecting mitochondrial membrane potential and inhibiting apoptosis.
- Inhibits GSK-3β signaling, reducing tau phosphorylation and decreasing Aβ production.
- Inhibits transcriptional activity and homodimerization of glucocorticoid receptor.
- Ameliorates dermal fibrosis in SSc mouse models by inhibiting TGF-β signaling pathway.
Medchemexpress LLC Pirenzepine dihydrochloride | 29868-97-1 | 99.8% | 424.32 | 1 ML
Pirenzepine dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist with poor penetration of the blood-brain barrier. It reduces gastric acid secretion and muscle spasm, and can be used in peptic ulcers research. Pirenzepine dihydrochloride also shows anti-proliferative activity to cancer cells.
- Selective M1 mAChR antagonist
- Poor penetration of the blood-brain barrier
- Reduces gastric acid secretion
- Reduces muscle spasm
- Can be used in peptic ulcers research
- Shows anti-proliferative activity to cancer cells