Oxazinanes
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 1 ML
Tebanicline dihydrochloride is a potent, orally effective analgesic that modulates neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits high selectivity for neuronal nAChRs, acting as an agonist, and effectively inhibits cytisine binding to α4β2 neuronal nAChRs. This product is investigated for its potential in treating various types of pain and for its anxiolytic-like properties.
- Potent and orally effective analgesic.
- Highly selective for neuronal nAChRs.
- Shows efficacy in models of acute, persistent, chemical, and neuropathic pain.
- Investigated for anxiolytic-like activity.
Medchemexpress LLC (3R,5R,6S)-Atogepant | 1374248-81-3 | 99.6% | 603.52 | 100 MG
(3R,5R,6S)-Atogepant is the enantiomer of Atogepant, a calcitonin gene-related peptide receptor (CGRP) antagonist. It is intended for research use only, specifically for studying migraine.
- Enantiomer of Atogepant
- CGRP receptor antagonist
- Molecular weight: 603.52
- Appearance: solid, white to off-white
- Suitable for migraine research
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 50 MG
Quizartinib dihydrochloride is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. It inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells and can induce apoptosis.
- Orally active FLT3 tyrosine kinase inhibitor
- Highly selective and potent
- Inhibits FLT3 and FLT3-ITD autophosphorylation
- Can be linked to VHL ligand for PROTAC FLT3 degrader formation
- Induces apoptosis
Medchemexpress LLC SP3N hydrochloride | 99.84% | 764.34 | 1 MG
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.
- Specific degrader of FKBP12.
- Metabolized to a reactive aldehyde (SP3CHO) which recruits SCFFBXO22 ligase for FKBP12 degradation.
- May be used in research for cancer.
Medchemexpress LLC 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | 956317-36-5 | 99.99% | C10H9N3O2 | 5 G
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is a chemical compound primarily utilized as a drug intermediate. This compound, identified by its CAS number 956317-36-5 and chemical formula C10H9N3O2, exhibits a high purity of 99.99%.
- Used as a building block in pharmaceutical synthesis
- High purity for reliable research applications
- Identified by a unique CAS number
- Characterized by its specific chemical formula
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.45% | 575.51 | 25 MG
Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity. It upregulates the cell cycle kinase inhibitor, p21WAF1/CIP1, and has shown additive antiproliferative activity in cell culture in combination with Paclitaxel. It inhibits tumor growth in athymic nude mice in a dose-responsive manner.
- High-affinity PPARγ agonist
- Upregulates p21WAF1/CIP1 cell cycle kinase inhibitor
- Shows additive antiproliferative activity with Paclitaxel
- Inhibits tumor growth in vivo
Medchemexpress LLC 4-Methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one | 50776-26-6 | 99.9% | C12H11NO | 5 G
4-Methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one is a chemical compound used as a drug intermediate for the synthesis of various active compounds. This product has a high purity of 99.9% and appears as a light yellow to yellow solid.
- Targeted as a drug intermediate
- Chemical formula: C12H11NO
- Molecular weight: 185.23
- Purity (LCMS): 99.9%
- Appearance: Light yellow to yellow solid
- Storage as powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | 956317-36-5 | MFCD18382679 | >99.99% | C10H9N3O2 | 500 G
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is a solid chemical intended for laboratory use and substance manufacturing. It has a melting point of 175.4-175.8°C, a boiling point of 413°C at 760 mmHg, and a flash point of 204°C. The product is stable under recommended storage conditions.
- Intended for laboratory chemicals
- Suitable for manufacture of substances
- Solid appearance
- Melting point: 175.4-175.8°C
- Boiling point: 413°C at 760 mmHg
- Flash point: 204°C
- Stable under recommended storage conditions
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 50 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) that can inhibit the growth of ER+ breast cancer cell lines in vitro and in vivo. It is effective against ERα and ERβ, making it suitable for research into hormone receptor-positive breast cancers.
- Orally available and selective estrogen receptor degrader (SERD)
- Inhibits the growth of ER+ breast cancer cell lines in vitro and in vivo
- Effective against ERα and ERβ targets
- Suitable for various research applications in breast cancer studies
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 5 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) that inhibits the growth of ER+ breast cancer cell lines both in vitro and in vivo. It has IC50s of 48 nM for ERα and 870 nM for ERβ. This product is for research use only and not sold to patients.
- Orally available and selective estrogen receptor degrader
- Inhibits the growth of ER+ breast cancer cell lines
- For research use only
- Appearance: white to off-white solid
- Shipped at room temperature
- Stored at 4°C, sealed, away from moisture
- In solvent, stored at -80°C for 6 months or -20°C for 1 month
eMolecules 1289167-38-9 | 5,6-Dibromo-2,3-dihydro-1H-inden-1-one | Ambeed | MFCD21360155 | 289.954 | C9H6Br2O | 97.000 | Brc1cc2CCC(=O)c2cc1Br | 1g | 627733155
5,6-Dibromo-2,3-dihydro-1H-inden-1-one | Ambeed | 1289167-38-9 | MFCD21360155 | 289.954 | C9H6Br2O | 97.000 | Brc1cc2CCC(=O)c2cc1Br | 1g | 627733155
Medchemexpress LLC Febrifugine dihydrochloride | 32434-42-7 | 1 MG
Febrifugine dihydrochloride is a quinazolinone alkaloid with antimalarial activity against *P. falciparum*. It also shows anticancer properties in bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids, leading to G1 phase increase and G2 phase decrease in cancer cells. Its action involves suppressing DNA synthesis and promoting apoptosis via downregulating key steroidogenesis factors.
- Inhibits *P. falciparum*.
- Possesses antimalarial activity.
- Inhibits bladder cancer cell proliferation.
- Induces apoptosis in bladder cancer cells.
- Reduces steroid synthesis in bladder cancer cells.
- Increases eIF2α phosphorylation in *P. falciparum*.
- Increases G1 phase cells and decreases G2 phase cells in bladder cancer.
- Significantly reduces mortality and parasitemia in an animal model of malaria.
- Effectively inhibits bladder cancer xenograft proliferation in mice.
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | MFCD00049357 | 99.8% | 239.23 | 25 MG
7,8-Dihydro-L-biopterin | 6779-87-9 | MFCD00049357 | 99.8% | 239.23 | 25 MG
eMolecules 139631-62-2 | Cyclopropanesulphonyl chloride | Apollo Scientific | MFCD01631933 | 140.580 | C3H5ClO2S | 95.000 | ClS(=O)(=O)C1CC1 | 100g | 562447064
Cyclopropanesulphonyl chloride | Apollo Scientific | 139631-62-2 | MFCD01631933 | 140.580 | C3H5ClO2S | 95.000 | ClS(=O)(=O)C1CC1 | 100g | 562447064
eMolecules 5807-14-7 | 1,5,7-Triazabicyclo[4.4.0]dec-5-ene | AA Blocks LLC | MFCD00043003 | 139.202 | C7H13N3 | 0.000 | C1CNC2=NCCCN2C1 | 100g | 784378699
1,5,7-Triazabicyclo[4.4.0]dec-5-ene | AA Blocks LLC | 5807-14-7 | MFCD00043003 | 139.202 | C7H13N3 | 0.000 | C1CNC2=NCCCN2C1 | 100g | 784378699