Oxazinanes
eMolecules 1205751-07-0 | Morpholine-2-carbonitrile hydrochloride | ChemScene | MFCD14582597 | 148.590 | C5H9ClN2O | 95.000 | Cl.N#CC1CNCCO1 | 1g | 632312733
Morpholine-2-carbonitrile hydrochloride | ChemScene | 1205751-07-0 | MFCD14582597 | 148.590 | C5H9ClN2O | 95.000 | Cl.N#CC1CNCCO1 | 1g | 632312733
TARGETMOL CHEMICALS INC S-ERSO 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. (S)-ErSO is an inactive dextrorotatory enantiomer of ErSO. purity: 97%
Selleck Chemical LLC K-115 hydrochloride dihydrate
Ripasudil hydrochloride dihydrate is a potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2 respectively used for the treatment of glaucoma and ocular hypertension
Selleck Chemical LLC K-115 hydrochloride dihydrate
Ripasudil hydrochloride dihydrate is a potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2 respectively used for the treatment of glaucoma and ocular hypertension
Apexbio Technology LLC Xamoterol hemifumarate 73210-73-8 5mg
Xamoterol hemifumarate (CAS 73210-73-8) is a selective 1-adrenergic receptor agonist targeting cardiac 1 receptors It is designed to activate 1-adrenergic signaling pathways thereby modulating myocardial function and cardiac electrophysiological processes Xamoterol hemifumarate exerts its biological activity primarily through 1-adrenergic receptor stimulation influencing downstream intracellular signaling cascades related to cardiac rhythm regulation In experimental settings it is utilized in vitro with cellular cardiac models and in vivo with animal models to assess 1-adrenergic receptor-mediated effects particularly in the interaction with cardiac ion channels such as the rapid delayed rectifier potassium current (IKr) Based on these pharmacological properties Xamoterol hemifumarate holds research potential in the study of arrhythmogenesis mechanisms and cardiac electrophysiology
Apexbio Technology LLC THIP hydrochloride 85118-33-8 10mM (in 1mL DMSO)
THIP hydrochloride (CAS 85118-33-8) is a small-molecule agonist of GABA receptors with primary activity in the central nervous system It selectively binds to GABAA receptor subtypes displaying affinity for 1 2 2 5 and 4 3 subunits In pharmacological studies THIP hydrochloride demonstrates subunit-specific efficacy with ED50 values of 143 M for 1 2 2 28 129 M for 5 and 6 M for 4 3 This compound is widely employed as a research tool in neuroscience to investigate GABAergic neurotransmission receptor pharmacology and explore potential therapeutic strategies related to neural modulation
Apexbio Technology LLC GW311616 hydrochloride 197890-44-1 10mM (in 1mL DMSO)
GW311616 hydrochloride (CAS 197890-44-1) is a selective cell-permeable inhibitor of human neutrophil elastase (HNE) exhibiting an IC50 of 22 nM and a Ki of 0 13 nM in enzymatic assays It demonstrates pronounced selectivity with IC50 values exceeding 100 M for trypsin cathepsin G and plasmin and greater than 3 M for chymotrypsin and tissue plasminogen activator In human whole blood assays GW311616 hydrochloride achieves an IC50 of 0 67 M The compound is orally bioavailable and displays prolonged activity in dog blood samples indicating a sustained inhibitory effect on neutrophil elastase GW311616 hydrochloride is valuable for investigating HNE s role in inflammation and related pathologies
Apexbio Technology LLC Rilmenidine (hemifumarate) 207572-68-7 50mg
Rilmenidine (hemifumarate CAS 207572-68-7) is an antihypertensive small molecule that primarily acts as an agonist at imidazoline I1 receptors within the rostral ventrolateral medulla thereby inhibiting the tonic activity of sympathoexcitatory neurons and reducing arterial pressure In vitro assays show that rilmenidine displays approximately 30-fold selectivity for imidazoline versus 2-adrenergic binding sites and a Ki of 7 1 nM for I1 receptors with significantly lower affinity for I2 sites (Ki 5 2 M) In vivo studies indicate efficacy in lowering blood pressure and ameliorating features of metabolic syndrome in rodent models as well as inducing autophagy and attenuating neurodegenerative pathology in a mouse model of Huntington s disease supporting its utility in cardiovascular and neurodegenerative research
TARGETMOL CHEMICALS INC RS 67333 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RS 67333 hydrochloride (RO5203648) is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A 5-HT1D 5-HT2A 5-HT2C dopamine D1 D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride shows neuroprotective effects and can be used for Alzheimer's disease research. purity: 98%
TARGETMOL CHEMICALS INC LURASIDONE HYDROCHLORIDE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist serotonin 5-HT7 receptor antagonist an antagonist of the adrenergic (alpha)2A and (alpha)2C receptors as well as a partial serotonin 5-HT1A receptor agonist. It is used in the treatment of schizophrenia and bipolar disorder. purity: 99%
TARGETMOL CHEMICALS INC LY 456236 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective non-competitive and oral activity and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 uM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 uM. purity: 99%
Apexbio Technology LLC Sinomenine Hydrochloride 6080-33-7 10mM (in 1mL DMSO)
Sinomenine Hydrochloride (CAS 6080-33-7) is an alkaloid derivative isolated from the stems of Sinomenium acutum It acts primarily by modulating the immune response through inhibition of pro-inflammatory cytokine production and suppression of NF- B signaling pathways Sinomenine Hydrochloride has been used in preclinical studies to investigate its anti-inflammatory and immunosuppressive activities particularly in models of rheumatoid arthritis and other autoimmune conditions This compound is suited for use in biomedical research exploring inflammation immune modulation and related therapeutic mechanisms Store in a sealed container under cool dry conditions
Accela Chembio Inc 3-morpholinobenzaldehyde | 1g | 446866-87-1 | MFCD07772811 | 97+% | Shelf Life: 2160 Days | Light Sensitive/n2/+4
3-morpholinobenzaldehyde | 1g | 446866-87-1 | MFCD07772811 | 97+% | Shelf Life: 2160 Days | Light Sensitive/n2/+4
Selleck Chemical LLC Ellipticine hydrochloride
Ellipticine Hydrochloride (NSC 71795 PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity
Apexbio Technology LLC MPC 6827 hydrochloride 917369-31-4 10mM (in 1mL DMSO)
MPC 6827 hydrochloride (CAS 917369-31-4) also known as Azixa is a small-molecule microtubule destabilizer that binds to the colchicine site on -tubulin By disrupting microtubule dynamics it induces mitotic arrest at the G2-M phase resulting in apoptotic cell death In preclinical models MPC 6827 has suppressed the growth of various subcutaneously implanted tumor cell lines and demonstrated vascular disruptive activity in human ovarian cancer xenografts Additionally it has shown synergy with carboplatin and inhibited glioblastoma growth in intracranial xenograft models MPC 6827 is utilized in cancer research to elucidate microtubule-targeting mechanisms and investigate tumor biology