Oxazinanes
TARGETMOL CHEMICALS INC LEONURINE HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Leonurine hydrochloride (SCM-198 hydrochloride) a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae) is considered to have antitumor roles. purity: 99%
TARGETMOL CHEMICALS INC DELAPRIL HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Delapril hydrochloride (indalapril) is a prodrug; it is converted into two active metabolites 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE) hence blocking angiotensin I to angiotensin II conversion. purity: 99%
![eMolecules 1577233-75-0 | 4-[(Tributylstannyl)methoxy]-1-butanamine | Synthonix - Stock | MFCD30717996 | 392.215 | C17H39NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)COCCCCN | 1g | 525923616](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696612.jpg-250.jpg)
eMolecules 1577233-75-0 | 4-[(Tributylstannyl)methoxy]-1-butanamine | Synthonix - Stock | MFCD30717996 | 392.215 | C17H39NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)COCCCCN | 1g | 525923616
4-[(Tributylstannyl)methoxy]-1-butanamine | Synthonix - Stock | 1577233-75-0 | MFCD30717996 | 392.215 | C17H39NOSn | 97.000 | CCCC[Sn](CCCC)(CCCC)COCCCCN | 1g | 525923616
Apexbio Technology LLC Rilmenidine (hemifumarate) 207572-68-7 10mg
Rilmenidine (hemifumarate CAS 207572-68-7) is an antihypertensive small molecule that primarily acts as an agonist at imidazoline I1 receptors within the rostral ventrolateral medulla thereby inhibiting the tonic activity of sympathoexcitatory neurons and reducing arterial pressure In vitro assays show that rilmenidine displays approximately 30-fold selectivity for imidazoline versus 2-adrenergic binding sites and a Ki of 7 1 nM for I1 receptors with significantly lower affinity for I2 sites (Ki 5 2 M) In vivo studies indicate efficacy in lowering blood pressure and ameliorating features of metabolic syndrome in rodent models as well as inducing autophagy and attenuating neurodegenerative pathology in a mouse model of Huntington s disease supporting its utility in cardiovascular and neurodegenerative research
Apexbio Technology LLC PRE-084 hydrochloride 75136-54-8 10mM (in 1mL DMSO)
PRE-084 hydrochloride (CAS 75136-54-8) is a selective agonist of the sigma-1 receptor ( 1R) demonstrating high affinity and specificity over sigma-2 receptors (Ki values 2 2 nM for 1R 13091 nM for 2R) and negligible activity at PCP and other receptor systems (IC50 100 000 nM) In neuronal cell models expressing mutant huntingtin PRE-084 enhances NF- B pathway activation improving antioxidant responses and cell survival In vivo it reverses cognitive impairment induced by CO or trimethyltin and reduces cough response in guinea pig models highlighting PRE-084 as a relevant tool for neurological and respiratory research
eMolecules 90902-84-4 | 2,5-Dibromopyridin-3-amine | ChemScene | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 5g | 536793574
2,5-Dibromopyridin-3-amine | ChemScene | 90902-84-4 | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 5g | 536793574
Apexbio Technology LLC GW311616 hydrochloride 197890-44-1 10mM (in 1mL DMSO)
GW311616 hydrochloride (CAS 197890-44-1) is a selective cell-permeable inhibitor of human neutrophil elastase (HNE) exhibiting an IC50 of 22 nM and a Ki of 0 13 nM in enzymatic assays It demonstrates pronounced selectivity with IC50 values exceeding 100 M for trypsin cathepsin G and plasmin and greater than 3 M for chymotrypsin and tissue plasminogen activator In human whole blood assays GW311616 hydrochloride achieves an IC50 of 0 67 M The compound is orally bioavailable and displays prolonged activity in dog blood samples indicating a sustained inhibitory effect on neutrophil elastase GW311616 hydrochloride is valuable for investigating HNE s role in inflammation and related pathologies
Apexbio Technology LLC Rilmenidine (hemifumarate) 207572-68-7 50mg
Rilmenidine (hemifumarate CAS 207572-68-7) is an antihypertensive small molecule that primarily acts as an agonist at imidazoline I1 receptors within the rostral ventrolateral medulla thereby inhibiting the tonic activity of sympathoexcitatory neurons and reducing arterial pressure In vitro assays show that rilmenidine displays approximately 30-fold selectivity for imidazoline versus 2-adrenergic binding sites and a Ki of 7 1 nM for I1 receptors with significantly lower affinity for I2 sites (Ki 5 2 M) In vivo studies indicate efficacy in lowering blood pressure and ameliorating features of metabolic syndrome in rodent models as well as inducing autophagy and attenuating neurodegenerative pathology in a mouse model of Huntington s disease supporting its utility in cardiovascular and neurodegenerative research
TARGETMOL CHEMICALS INC RS 67333 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RS 67333 hydrochloride (RO5203648) is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A 5-HT1D 5-HT2A 5-HT2C dopamine D1 D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride shows neuroprotective effects and can be used for Alzheimer's disease research. purity: 98%
TARGETMOL CHEMICALS INC ELSIBUCOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury. purity: 98%
TARGETMOL CHEMICALS INC Ruboxistaurin hydrochloride
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCbetaI and PKCbetaII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCbeta over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 uM for PKCη, -delta, -gamma, -alpha, - and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Purity 98.44%
Accela Chembio Inc 3-fluoro-4-morpholinoaniline | 1g | 93246-53-8 | MFCD02571270 | 97+% | Shelf Life: 1620 Days | Light Sensitive/+4
3-fluoro-4-morpholinoaniline | 1g | 93246-53-8 | MFCD02571270 | 97+% | Shelf Life: 1620 Days | Light Sensitive/+4
TARGETMOL CHEMICALS INC Simmitecan hydrochloride 1MG
Also available in 5 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors. Purity 98.36%
Selleck Chemical LLC Kevetrin hydrochloride
Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble small molecule and activator of the tumor suppressor protein p53 with potential antineoplastic activity
TARGETMOL CHEMICALS INC OTSSP167 HYDROCHLORIDE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 0.41 nM). purity: 99%