Oxazinanes
TARGETMOL CHEMICALS INC Orphenadrine hydrochloride
Also available in 1 g, 1 mL, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. Purity 99.54%
Medchemexpress LLC Pramipexole dihydrochloride | 104632-25-9 | 99.7% | 284.25 | 1 ML
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective dopamine D2-type receptor agonist
- BBB penetrant
- Useful for research into Parkinson's disease (PD) and restless legs syndrome (RLS)
- Cytoprotective properties
- Reduces infarction volume
- Improves neurological recovery
- Prevents ischemic cell death
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
![eMolecules 1293987-58-2 | 7-bromothieno[3,2-d]pyrimidin-2-amine | Advanced ChemBlocks230.080 | C6H4BrN3S | 95.000 | Nc1ncc2scc(Br)c2n1 | 1g | 798808266](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694556.jpg-250.jpg)
eMolecules 1293987-58-2 | 7-bromothieno[3,2-d]pyrimidin-2-amine | Advanced ChemBlocks230.080 | C6H4BrN3S | 95.000 | Nc1ncc2scc(Br)c2n1 | 1g | 798808266
7-bromothieno[3,2-d]pyrimidin-2-amine | Advanced ChemBlocks | 1293987-58-2230.080 | C6H4BrN3S | 95.000 | Nc1ncc2scc(Br)c2n1 | 1g | 798808266
Selleck Chemical LLC Filanesib hydrochloride
Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis and cell proliferation
Selleck Chemical LLC Midodrine hydrochloride
Midodrine hydrochloride is the hydrochloride salt form of midodrine an adrenergic alpha-1 agonist used as a vasopressor
eMolecules 16681-67-7 | 4-Bromo-2-methyl-2H-1,2,3-triazole | ChemScene | MFCD23378485 | 161.990 | C3H4BrN3 | 95.000 | Cn1ncc(Br)n1 | 1g | 536782377
4-Bromo-2-methyl-2H-1,2,3-triazole | ChemScene | 16681-67-7 | MFCD23378485 | 161.990 | C3H4BrN3 | 95.000 | Cn1ncc(Br)n1 | 1g | 536782377
Medchemexpress LLC 13,14-dihydro-15-keto prostaglandin D2 | 59894-07-4 | MFCD00885499 | 99.9% | 352.47 | C20H32O5 | 1 MG
13,14-dihydro-15-keto prostaglandin D2 is a chemically defined metabolite of prostaglandin D2 supplied as a high-purity research standard for analytical and pharmacological studies. It is provided as a solution in methyl acetate and intended for use as an analytical reference or reagent in biochemical assays.
- High purity analytical standard (99.9%).
- Chemical formula C20H32O5; molecular weight 352.47 g/mol.
- Supplied as a solution in methyl acetate for convenient handling.
- Provided in small milligram-scale quantities suitable for standards and assays.
- Store solution at -20°C; stable for up to 2 years when stored properly.
- Documentation available: certificate of analysis and safety data sheet.
Selleck Chemical LLC Bobcat339 hydrochloride
Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 M and 73 M for TET1 and TET2 respectively Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe
Medchemexpress LLC Sapropterin dihydrochloride (standard) | 69056-38-8 | 100.0% | C9H17Cl2N5O3 | 5 MG
Sapropterin dihydrochloride (Standard) is the analytical standard of Sapropterin (dihydrochloride), intended for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, reducing blood phenylalanine concentrations, and is used in the study of phenylketonuria (PKU). Additionally, it can aggravate experimental autoimmune encephalomyelitis (EAE).
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Used in the study of phenylketonuria (PKU)
- Can aggravate experimental autoimmune encephalomyelitis (EAE)
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | 99.79% | 239.23 | 100 MG
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer that can cross the blood-brain barrier. It is a reduced non-conjugated pteridine and the main metabolite of 4-amino-tetrahydro-L-biopterin, which undergoes photooxidation to form biopterin. This compound promotes the conversion of nitric oxide synthase to a superoxide-producing form, leading to increased oxidative stress in the renal outer medulla and inducing apoptosis.
- NOS uncoupling inducer
- Can cross the blood-brain barrier
- Promotes conversion of nitric oxide synthase to a superoxide-producing form
- Increases oxidative stress in the renal outer medulla
- Induces apoptosis
- Sensitive to inhibitory effect of SOD
- Used in research related to salt-sensitive hypertension and neurodegenerative diseases
Apexbio Technology LLC Midodrine (hydrochloride) 43218-56-0 250mg
Midodrine hydrochloride (CAS 43218-56-0) is a prodrug that is metabolized to desglymidodrine a selective agonist of 1-adrenergic receptors It exhibits binding affinities (Ki) of 2 M 6 9 M and 1 7 M for the 1A 1B and 1D receptor subtypes respectively Activation of these receptors mediates vasoconstriction in arteriolar and venous smooth muscle resulting in increased vascular tone and blood pressure Preclinical studies have also shown that central administration of midodrine affects thermoregulation and locomotor activity in animal models Research applications include investigation of adrenergic signaling cardiovascular regulation and combination therapy for refractory ascites
Apexbio Technology LLC Pitolisant hydrochloride 903576-44-3 10mM (in 1mL DMSO)
Pitolisant hydrochloride (CAS 903576-44-3) also known as BF2 649 or Ciproxidine is a potent and selective non-imidazole inverse agonist of the histamine H3 receptor exhibiting a Ki of 0 16 nM for the human recombinant receptor By targeting the H3 autoreceptor pitolisant modulates histaminergic neurotransmission and regulates the release of other neurotransmitters In vitro it demonstrates higher intrinsic activity than ciproxifan and an EC50 of 1 5 nM Pitolisant is orally bioavailable and increases brain tele-methylhistamine levels in rodents in a dose-dependent manner reflecting activation of histaminergic neurons It is widely applied in studies related to cognition epilepsy and models of neuropsychiatric disorders
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | C24H34Cl3N5O2 | 1 ML
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor. It exhibits IC50s of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3. This product is intended for research use only.
- Highly selective and ATP-competitive pan-Akt inhibitor
- IC50s of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3
- Purity 99.19%
- Molecular weight 530.92
- Chemical formula C24H34Cl3N5O2
- Provided as a 10 mM solution in DMSO