Oxazinanes
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.9% | 575.51 g/mol | C27H28Cl2N4O4S | 10 MG
Inolitazone dihydrochloride is a research-grade, high-affinity peroxisome proliferator-activated receptor gamma (PPARγ) agonist. It is PPARγ-dependent for its biological activity and has demonstrated potent growth-inhibitory effects (reported IC50 ≈ 0.8 nM). The compound is used in cell proliferation and combination therapy studies and is supplied for research use only.
- High-affinity PPARγ agonist with potent activity.
- Demonstrated growth inhibition with IC50 ≈ 0.8 nM.
- Upregulates p21 (WAF1/CIP1), useful in cell cycle studies.
- Suitable for cell proliferation and combination therapy research.
- Provided at high purity (≈98.9%) suitable for analytical assays.
- Available in multiple small pack sizes for laboratory use.
TARGETMOL CHEMICALS INC SAMURACICLIB HYDROCHLORI 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent selective ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45- 15- 230- and 30-fold higher than CDK1 CDK2 (IC50 is 578 nM) CDK5 and CDK9 respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 uM. Samuraciclib hydrochloride has anti-tumor effects. purity: 99%
Medchemexpress LLC 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregn-4-ene-3,20-dione | 426-17-5 | MFCD22683747 | 5mg
1 2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity
Apexbio Technology LLC PJ34 hydrochloride 344458-15-7 10mM (in 1mL DMSO)
PJ34 hydrochloride (CAS 344458-15-7) is a small molecular inhibitor targeting poly(ADP-ribose) polymerase (PARP) an enzyme critical for DNA repair and cellular proliferation In vitro assays demonstrate dose-dependent inhibition of purified PARP activity with an EC50 of approximately 20 nM Unlike other inhibitors such as 3-aminobenzamide (3-AB) PJ34 lacks antioxidant properties and exhibits significantly higher inhibitory potency against PARP Experimental studies have shown PJ34 protects against peroxynitrite-induced cell necrosis (EC50 20 nM) and dose-dependently suppresses proliferation in HepG2 liver cancer cell lines enhancing chemotherapeutic efficacy and conferring neuroprotection in various disease models
eMolecules 16681-67-7 | 4-Bromo-2-methyl-2H-1,2,3-triazole | ChemScene | MFCD23378485 | 161.990 | C3H4BrN3 | 95.000 | Cn1ncc(Br)n1 | 25g | 632276599
4-Bromo-2-methyl-2H-1,2,3-triazole | ChemScene | 16681-67-7 | MFCD23378485 | 161.990 | C3H4BrN3 | 95.000 | Cn1ncc(Br)n1 | 25g | 632276599
Cayman Chemical CP 24 879 hydrochloride
A Δ5/Δ6 desaturase inhibitor; reduces liver arachidonate content by ~50% in mice at 3 mg/kg; increases mead acid content and inhibits leukotriene C4 synthesis in murine mastocytoma cells at 5 µM
Medchemexpress LLC Tirbanibulin dihydrochloride | 1038395-65-1 | MFCD18633218 | 98.0% | 504.45 | C26H31Cl2N3O3 | 10 MG
Tirbanibulin dihydrochloride is the dihydrochloride salt of tirbanibulin, a peptidomimetic Src inhibitor that targets the peptide-substrate site of Src and demonstrates GI50 values of approximately 9-60 nM in cancer cell lines. This product is supplied as a purified analytical standard for research and analytical applications.
- Src inhibitor targeting the peptide-substrate site
- Dihydrochloride salt form for improved handling and solubility
- Supplied as a solid analytical standard for research use
- Reported purity ~98.0%
- Molecular weight 504.45; formula C26H31Cl2N3O3
- CAS number 1038395-65-1
- Suitable for in vitro and analytical assays
TARGETMOL CHEMICALS INC LEVOBETAXOLOL HYDROCHLOR 100MG
Also available in 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) is a beta-adrenergic receptor inhibitor (beta blocker) used to lower the pressure in the eye in treating conditions such as glaucoma. purity: 99%
eMolecules 1060815-73-7 | 2-Amino-6-bromo-3-chloropyridine | Allbio Pharm Co.,Ltd | MFCD13189347 | 207.460 | C5H4BrClN2Nc1nc(Br)ccc1Cl | 1g | 816453081
2-Amino-6-bromo-3-chloropyridine | Allbio Pharm Co.,Ltd | 1060815-73-7 | MFCD13189347 | 207.460 | C5H4BrClN2Nc1nc(Br)ccc1Cl | 1g | 816453081
TARGETMOL CHEMICALS INC COT INHIBITOR-1 HYDROCHL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-(alpha) in human whole blood (IC50 = 5.7 nM).
![eMolecules 1820569-61-6 | Ethyl (R)-morpholine-2-carboxylate hydrochloride | ChemScene | MFCD26792471 | 195.640 | C7H14ClNO3 | 96.000 | Cl.CCOC(=O)[C@H]1CNCCO1 | 1g | 726025218](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694764.jpg-250.jpg)
eMolecules 1820569-61-6 | Ethyl (R)-morpholine-2-carboxylate hydrochloride | ChemScene | MFCD26792471 | 195.640 | C7H14ClNO3 | 96.000 | Cl.CCOC(=O)[C@H]1CNCCO1 | 1g | 726025218
Ethyl (R)-morpholine-2-carboxylate hydrochloride | ChemScene | 1820569-61-6 | MFCD26792471 | 195.640 | C7H14ClNO3 | 96.000 | Cl.CCOC(=O)[C@H]1CNCCO1 | 1g | 726025218
Apexbio Technology LLC 1 2-Distearoyl-sn-glycero-3-PE 250mg
1 2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphatidylethanolamine (PE) lipid that can be used for preparing liposomes employed in drug delivery gene transfection and vaccine delivery
TARGETMOL CHEMICALS INC SBE13 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50 0.2 nM); no inhibition om Aurora A kinase Plk2/3. purity: 99%
TARGETMOL CHEMICALS INC PD0166285 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. purity: 99%
TARGETMOL CHEMICALS INC Syk Inhibitor II hydrochloride
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-beta-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines. Purity 98.17%