A serotonin, norepinephrine, and dopamine reuptake inhibitor (Kis = 137, 570, 2,380 nM, respectively); an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-ARs (Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively); reduces immobility time in the tail suspension test in gerbils at 100 mg/kg; toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation at 30 µM