Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Aneratrigine hydrochloride is a sodium channel protein type 9 subunit blocker that may be used for the prevention or treatment of sodium channel blocker-related diseases. Purity 99.39%
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3 which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and as of now there are no serious concerns about its side effects. purity: 99%
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Also available in 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes.Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel. Purity 98.71%
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Bisaramil hydrochloride (Bisaramil) is a novel diazabicyclononane antiarrhythmic compound that inhibits the generation of free radicals.Bisaramil hydrochloride blocks sodium currents and inhibits the slow Ca(2+) action potential induced by isoproterenol in K(+)-depolarized muscle. Purity 99.64%
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k. Purity 99.71%
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibits biogenic amine uptake.Besipirdine hydrochloride reduces schedule-induced thirst and enhances cholinergic and adrenergic neurotransmission in the central nervous system in rats. Purity 98.4%
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Prilocaine hydrochloride (CAS 1786-81-8) is a local anesthetic belonging to the amino amide class It functions by reversibly inhibiting voltage-gated sodium channels on neuronal cell membranes thereby blocking the initiation and propagation of nerve impulses This property makes it suitable for investigating neuronal excitability pain signaling and ion channel pharmacology in various preclinical models Prilocaine hydrochloride is commonly employed in studies requiring local anesthesia and serves as a reference compound for benchmarking novel anesthetic agents in research settings
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AMTB hydrochloride (CAS 926023-82-7) is a selective antagonist of the TRPM8 ion channel effectively inhibiting TRPM8-mediated activation induced by agonists such as icilin with a reported pIC50 of approximately 6 23 In addition to its primary action AMTB hydrochloride also exhibits non-selective inhibitory effects on voltage-gated sodium channels (NaV) This compound is commonly utilized in biomedical research to investigate the role of TRPM8 channel activity alterations in the pathophysiology of bladder overactivity and bladder pain syndrome
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Aliskiren Hemifumarate (CAS 173334-58-2) is a small molecule classified as a direct renin inhibitor By binding to renin it blocks the initial step in the renin-angiotensin-aldosterone system (RAAS) thereby reducing the conversion of angiotensinogen to angiotensin I and lowering downstream angiotensin II levels This mechanism results in decreased vasoconstriction and aldosterone-mediated sodium retention Aliskiren Hemifumarate is primarily studied in the context of essential hypertension and serves as a tool compound for exploring renin-dependent regulatory pathways and therapeutic strategies targeting blood pressure homeostasis
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Aliskiren Hemifumarate (CAS 173334-58-2) is a small molecule classified as a direct renin inhibitor By binding to renin it blocks the initial step in the renin-angiotensin-aldosterone system (RAAS) thereby reducing the conversion of angiotensinogen to angiotensin I and lowering downstream angiotensin II levels This mechanism results in decreased vasoconstriction and aldosterone-mediated sodium retention Aliskiren Hemifumarate is primarily studied in the context of essential hypertension and serves as a tool compound for exploring renin-dependent regulatory pathways and therapeutic strategies targeting blood pressure homeostasis
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