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MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3 which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and as of now there are no serious concerns about its side effects. purity: 99%
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GPNA hydrochloride is identified as a substrate of the enzyme γ-glutamyltransferase (GGT) and a specific glutamine (Gln) transporter ASCT2 inhibitor. It also inhibits Na+-dependent carriers like the SNAT family (SNAT1/2/4/5) and Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells.
Substrate of the enzyme γ-glutamyltransferase (GGT)
Specific glutamine (Gln) transporter ASCT2 inhibitor
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Aneratrigine hydrochloride is a sodium channel protein type 9 subunit blocker that may be used for the prevention or treatment of sodium channel blocker-related diseases. Purity 99.39%
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GPNA hydrochloride (L- -glutamyl-p-nitroanilide hydrochloride) is a substrate of -glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of 250 M in A549 cells It also inhibits Na -dependent carriers SNAT1 -2 -4 -5 and Na -independent leucine transporters LAT1/2 It can be widely used in research on pancreatic cancer breast cancer glioblastoma multiforme acute myelogenous leukemia and non-small-cell lung cancer
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GPNA hydrochloride (L- -glutamyl-p-nitroanilide hydrochloride) is a substrate of -glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of 250 M in A549 cells It also inhibits Na -dependent carriers SNAT1 -2 -4 -5 and Na -independent leucine transporters LAT1/2 It can be widely used in research on pancreatic cancer breast cancer glioblastoma multiforme acute myelogenous leukemia and non-small-cell lung cancer
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GPNA hydrochloride (L- -glutamyl-p-nitroanilide hydrochloride) is a substrate of -glutamyltransferase (GGT) and an inhibitor of the glutamine transporter ASCT2 with an IC50 of 250 M in A549 cells It also inhibits Na -dependent carriers SNAT1 -2 -4 -5 and Na -independent leucine transporters LAT1/2 It can be widely used in research on pancreatic cancer breast cancer glioblastoma multiforme acute myelogenous leukemia and non-small-cell lung cancer
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Vernakalant (RSD-1235 MK-6621) is a novel frequency-dependent Na channel and early activating K channel blocker that selectively prolongs the atrial refractory period
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Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker and a D2 dopamine receptor antagonist. It demonstrates anticonvulsive and antimigraine activity, as well as peripheral vasodilator effects.
Potent dual Na+/Ca2+ channel (T-type) blocker
D2 dopamine receptor antagonist
Shows anticonvulsive and antimigraine activity
Provides peripheral vasodilator effects
For research use only
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Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker and a D2 dopamine receptor antagonist. It exhibits anticonvulsive, antimigraine, and peripheral vasodilator effects.
Potent dual Na+/Ca2+ channel (T-type) blocker
D2 dopamine receptor antagonist
Exhibits anticonvulsive activity
Exhibits antimigraine activity
Exhibits peripheral vasodilator effects
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Also available in 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme (gamma)-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers such as SNAT family (SNAT1/2/4/5) and the Na+-independent leucine transporters LAT1/2. purity: 99%
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Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker and a D2 dopamine receptor antagonist. It exhibits anticonvulsive and antimigraine activity, alongside peripheral vasodilator effects.
Potent dual Na+/Ca2+ channel (T-type) blocker
D2 dopamine receptor antagonist
Exhibits anticonvulsive and antimigraine activity
Shows peripheral vasodilator effects
Target: T-type calcium channel and D2 receptor
Solubility in DMSO: 50 mg/mL (104.73 mM)
Solubility in H2O: 1 mg/mL (2.09 mM)
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Also available in 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes.Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel. Purity 98.71%
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