Oxazinanes
Medchemexpress LLC HXR9 hydrochloride | 99.5% | 2754.67 | 1 MG
HXR9 hydrochloride is a cell-permeable peptide that acts as a competitive antagonist of HOX/PBX interaction. It selectively decreases cell proliferation and promotes apoptosis in cells with high HOXA/PBX3 gene expression, such as MLL-rearranged leukemic cells, by blocking the interaction between HOX and PBX transcription factors.
- Antagonizes the interaction between HOX and PBX transcription factors.
- Selectively decreases cell proliferation.
- Promotes apoptosis in cells with high HOXA/PBX3 gene expression.
- Appears as a white to off-white solid.
- Soluble in water (H2O) and PBS.
Selleck Chemical LLC Filanesib hydrochloride
Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis and cell proliferation
Selleck Chemical LLC Filanesib hydrochloride
Filanesib (ARRY-520) hydrochloride is a kinesin spindle protein (KSP) inhibitor that blocks the separation of centrosomes and assembly of spindles in the early stage of cell mitosis and cell proliferation
Apexbio Technology LLC AT7519 Hydrochloride 902135-91-5 10mM (in 1mL DMSO)
AT7519 Hydrochloride (CAS 902135-91-5) is a small-molecule inhibitor of cyclin-dependent kinases (CDKs) which are critical regulators of cell proliferation division and apoptosis in eukaryotic cells By targeting multiple CDKs including CDK1 and CDK2 AT7519 induces cell cycle arrest and apoptosis in various human tumor cell lines demonstrating inhibitory activity with IC50 values ranging from 40 to 940 nmol/L In preclinical studies it suppressed tumor growth in xenograft models and promoted tumor cell apoptosis AT7519 is under clinical evaluation for the treatment of refractory solid tumors supporting its utility in cancer research and drug development
Selleck Chemical LLC OTS514 hydrochloride
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2 6 nM OTS514 induces cell cycle arrest and apoptosis
Selleck Chemical LLC OTS514 hydrochloride
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2 6 nM OTS514 induces cell cycle arrest and apoptosis
Selleck Chemical LLC Irinotecan hydrochloride S5026-10mM/1mL
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Medchemexpress LLC Bomedemstat dihydrochloride | 99.55% | 592.54 | 25 MG
Bomedemstat dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation, which then alters gene expression. This compound exhibits anti-cancer activities by inhibiting cancer cell proliferation and inducing apoptosis, and is being investigated in multiple clinical trials.
- Selectively inhibits proliferation of Jak2V617F cells
- Induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner
- Leads to cell cycle arrest in SET-2 cells
- Normalizes or improves blood cell counts in Mx-Jak2V617F mice
- Reduces spleen volumes and restores normal splenic architecture in animal models
Medchemexpress LLC Aebsf (hydrochloride) | 30827-99-7 | 99.87% | 10 MM 1 ML
AEBSF hydrochloride is an irreversible inhibitor of serine proteases such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. It inhibits Aβ production by directly inhibiting β-secretase in various human cell lines and suppresses lysis of leukemic cells by human macrophages. It also interferes with blastocyst growth and HeLa cell adhesion. In vivo, AEBSF prolongs survival in *T. gondii* infection models and reduces inflammation in murine models.
- Irreversible inhibitor of serine proteases (chymotrypsin, kallikrein, plasmin, thrombin, and trypsin).
- Inhibits β-secretase and macrophage-mediated leukemic cell lysis.
- Disturbs blastocyst growth and cell adhesion.
- Supports research on *T. gondii* infection and inflammation.
- Appearance: Solid, white to off-white.
Medchemexpress LLC Vacquinol-1 dihydrochloride (NSC13316 dihydrochloride) | 2309312-85-2 | 99.7% | 425.78 | 100 MG
Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways. It specifically induces human glioblastoma cell (GC) death, attenuates tumor progression, and prolongs survival in a glioblastoma multiforme (GBM) mouse model. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC) cells.
- Activates MAPK pathways
- Induces human glioblastoma cell death
- Attenuates tumor progression
- Prolongs survival in a glioblastoma multiforme mouse model
- Induces apoptosis in hepatocellular carcinoma cells
Selleck Chemical LLC Irinotecan hydrochloride S5026-1g
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Selleck Chemical LLC Irinotecan hydrochloride S5026-100mg
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Selleck Chemical LLC Irinotecan hydrochloride S5026-25mg
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Medchemexpress LLC Bay 61-3606 dihydrochloride | 648903-57-5 | 99.45% | 463.32 | 50 MG
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible, and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and induces a large decrease of Syk phosphorylation in K-rn cell lysates. Additionally, Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells. It is for research use only and not intended for patient use.
- Significantly reduces the cell viability of SYK-positive SH-SY5Y and SYK-negative SK-N-BE cells in a dose-dependent manner.
- Inhibits SYK activity by reducing ERK1/2 and Akt phosphorylation in neuroblastoma cell SH-SY5Y.
- Induces a large decrease of Syk phosphorylation in K-rn cell lysates.
- Leads to more efficacious reductions than TNF-related apoptosis-inducing ligand (TRAIL) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice.
Medchemexpress LLC AX-024 hydrochloride | 1704801-24-0 | 99.2% | 375.86 g/mol | C21H23ClFNO2 | 1 ML
AX-024 hydrochloride is a small-molecule inhibitor of the T cell receptor-Nck interaction that selectively inhibits TCR-triggered T cell activation. Supplied for research use in biochemical and cell-based assays, it is available as a 10 mM solution in DMSO (1 mL) or as solids for custom preparation.
- Selective inhibitor of TCR-Nck interaction for T cell signaling studies.
- High purity suitable for biochemical and cell-based assays.
- Provided as a 10 mM DMSO solution for ready-to-use experiments.
- Also available in multiple solid sizes for dosing flexibility.
- Store sealed at cold temperatures to preserve stability.