Piperidines
Medchemexpress LLC Varenicline hydrochloride | 230615-23-3 | 99.9% | 247.72 g/mol | C13H14ClN3 | 5 MG
Varenicline hydrochloride is the hydrochloride salt of varenicline, an orally active partial agonist of the α4β2 nicotinic acetylcholine receptor. This compound is supplied as a research-grade chemical for in vitro and in vivo studies investigating nicotinic receptor pharmacology and models of nicotine dependence.
- High purity suitable for analytical and preclinical studies.
- Supplied as a hydrochloride salt for increased stability and solubility.
- Molecular formula C13H14ClN3 and molecular weight 247.72 g/mol.
- Identified by CAS number 230615-23-3 for unambiguous chemical reference.
- Compatible with common solvents such as DMSO for solution preparation.
- Intended for laboratory research use only.
Medchemexpress LLC HY-10020 50mg Medchemexpress, Varenicline (Hydrochloride) CAS:230615-23-3 Purity:>98%
Medchemexpress, HY-10020 50mg Varenicline (Hydrochloride) CAS:230615-23-3 Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist [1] [2] [3] . Varenicline Hydrochloride is also a potent partial agonist of α6β2 nAChR in striatum of rats with a K i value of 0.12 nM [4] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol | 371935-74-9 | MFCD11983145 | 99.0% | 348.36 g/mol | C19H16N4O3 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213142.png-250.jpg)
Medchemexpress LLC 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol | 371935-74-9 | MFCD11983145 | 99.0% | 348.36 g/mol | C19H16N4O3 | 50 MG
A small-molecule research reagent that potently inhibits PI3K and mTOR signaling and is used in biochemical and cell-based studies. It also inhibits DNA-PK and has been reported to induce autophagy.
- Potent PI3K and mTOR inhibitor with reported low-nanomolar IC50s (p110α 8 nM; mTORC1 20 nM).
- Also inhibits DNA-PK (IC50 2 nM).
- Used for biochemical and cell-based research; for research use only.
- Stable as a powder at -20°C (up to 3 years) or 4°C (up to 2 years).
- Recommended in-solution storage: -80°C (1 year) or -20°C (6 months).
- Supplied in milligram-scale quantities suitable for analytical and cellular studies.
eMolecules 1038915-73-9 | Medchem Express | Niraparib (tosylate) | 5mg | 446258956 | HY-10619B | MFCD28167748 | 492.59 | C26H28N4O4S
Ambeed | (11bR)-N-(26-Bis(4-methoxyphenyl)-4-oxido-89101112131415-octahydrodinaphtho[21-d12-f][132]dioxaphosphepin-4-yl)-111-trifluoromethanesulfonamide | 100mg | 633659999 | A1258444 | 1071853-99-0 | 699.680 | C35H33F3NO7PS
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Medchemexpress LLC HY-15418 50mg , RS 504393 CAS:300816-15-3 Purity:98%
Medchemexpress, HY-15418 50mg RS 504393 CAS:300816-15-3 Formula:C25H27N3O3 IC50: 98 nM (CCR2b) Purity:98% RS 504393 is a selective CCR2 chemokine receptor antagonist ( IC 50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC PI-1840 1401223-22-0 50mg
PI-1840 (CAS 1401223-22-0) is a potent selective and rapidly reversible noncovalent inhibitor of the proteasome chymotrypsin-like (CT-L) activity It exhibits an IC50 of 27 nM against CT-L catalytic function of the proteasome with significantly greater selectivity over other proteolytic activities including PGPH-L and T-L In MDA-MB-468 human breast cancer cells PI-1840 inhibits CT-L activity (IC50 0 37 M) suppresses cell viability and proliferation and induces accumulation of CT-L substrates such as I B- p27 and Bax ultimately triggering apoptosis via PARP cleavage and caspase-3 activation In vivo PI-1840 markedly reduces tumor growth in a breast cancer xenograft model This compound is valuable for investigating proteasome function apoptosis and cancer biology
Apexbio Technology LLC PI-3065 955977-50-1 50mg
PI-3065 (CAS 955977-50-1) is a selective small-molecule inhibitor targeting the phosphoinositide 3-kinase delta (PI3K ) isoform It exhibits potent inhibitory activity with reported Ki and IC50 values of approximately 1 5 nM and 5 nM respectively PI-3065 demonstrates marked selectivity showing significantly lower inhibitory potency against the related isoforms PI3K PI3K and PI3K In preclinical models treatment with PI-3065 suppressed growth and metastasis of 4T1 tumors extended survival and reduced tumor-related pathological outcomes This compound serves as a valuable tool for studying PI3K -driven signaling pathways in oncology and immunology research contexts
Medchemexpress LLC PI 3 Kinase p150 Antibody (YA2823) | 100 UL
The PI 3 Kinase p150 Antibody (YA2823) is a rabbit-derived antibody supplied as a liquid. It is intended for laboratory use in the manufacture of substances and is reactive with human, mouse, and rat samples. This antibody is stable under recommended storage conditions and has an observed molecular weight of 150 kDa.
- Reacts with human, mouse, and rat samples.
- Supports Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF), and Flow Cytometry (FC) applications.
- Formulated in rabbit IgG in 10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
- Stable for 1 year when stored at -20°C; avoid repeated freeze/thaw cycles.
- Shipped with blue ice to maintain stability.
Medchemexpress LLC Casopitant mesylate | 414910-30-8 | 99.1% | C31H39F7N4O5S | 50 MG
Casopitant mesylate (GW679769B) is a potent, selective, brain-permeable, and orally active neurokinin 1 (NK1) receptor antagonist. It is classified as a second-in-class antiemetic that counteracts the emetogenic effect of Substance P. It is utilized for the treatment of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).
- Potent, selective, brain-permeable, and orally active neurokinin 1 (NK1) receptor antagonist.
- Antagonizes the emetogenic effect of Substance P.
- Substrate and a weak-to-moderate inhibitor of CYP3A4.
- Used for the treatment of chemotherapy-induced nausea and vomiting (CINV).
- Used for the treatment of postoperative nausea and vomiting (PONV).
Medchemexpress LLC HY-101291 10mg Medchemexpress, Iberdomide CAS:1323403-33-3 Purity:>98%
Medchemexpress, HY-101291 10mg Iberdomide CAS:1323403-33-3 Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 value of 60 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC CC-885-5mg
CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.
eMolecules 161491-24-3 | METHYL N-BOC-4-OXOPIPERIDINE-3-CARBOXYLATE | AstaTech | MFCD08752608 | 257.286 | C12H19NO5 | 97.000 | COC(=O)C1CN(CCC1=O)C(=O)OC(C)(C)C | 5g | 206680767
METHYL N-BOC-4-OXOPIPERIDINE-3-CARBOXYLATE | AstaTech | 161491-24-3 | MFCD08752608 | 257.286 | C12H19NO5 | 97.000 | COC(=O)C1CN(CCC1=O)C(=O)OC(C)(C)C | 5g | 206680767
Medchemexpress LLC Lenalidomide-C5-NH2 (hydrochloride) | 2595367-27-2 | 98.4% | 500MG
Lenalidomide-C5-NH2 (hydrochloride) | 2595367-27-2 | 98.4% | 500MG
Biotium Fibronectin(HFN7.1), CF647 conjugate, 0.1mg/mL
Fibronectin is a dimeric glycoprotein of 440 kDa, which is present in cells, extracellular matrix, and blood. It possesses at least four binding sites for collagen, glycosaminoglycans, transglutaminase, and a cell surface receptor. Fibronectin is involved in cell adhesion, tissue organization, and wound healing. This MAb is directed against the peptide core and reacts with both the plasma and cellular forms of fibronectin. It blocks the fibronectin-medicated cell attachment not by disrupting the collagen-fibronectin interaction, but by interfering with the attachment of fibronectin to its receptor on the cell surface.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific ba
Medchemexpress LLC 2-piperidone (δ-valerolactam) | 675-20-7 | MFCD00006037 | 99.9% | 99.13 g/mol | C5H9NO | 1 ML
2-Piperidone is an endogenous metabolite used as a biomarker for cytochrome P450 2E1 (CYP2E1) activity and has reported hepatoprotective effects in CCl4-induced hepatotoxicity models in rats.
- Endogenous metabolite used as a biomarker for CYP2E1 activity.
- Reported hepatoprotective effects in CCl4-induced hepatotoxicity rat models.
- Available as a 10 mM solution (1 mL in DMSO) and as a solid in multiple pack sizes.
- High purity (99.89%).
- CAS number 675-20-7; molecular formula C5H9NO; molecular weight 99.13 g/mol.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- SDS and COA are provided for safe handling and quality verification.