Piperidines
Medchemexpress LLC Ropivacaine impurity 100mg
Ropivacaine impurity 1 hydrochloride is an impurity of Ropivacaine (HY-B0563)
AdipoGen Ropivacaine HCl H2O
Chemical. CAS 132112-35-7. Formula C17H26N2O . HCl . H2O. MW 274.4 . 36.5 . 18.0. Synthetic. Ropivacaine is a long-acting amide local anaesthetic agent. Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. It is a pure S-enantiomer and less lipophilic than racemic sodium channel blockers, such as bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity.
Apexbio Technology LLC Ropivacaine hydrochloride monohydrate 132112-35-7 10mM (in 1mL DMSO)
Ropivacaine hydrochloride monohydrate (CAS 132112-35-7) is a long-acting amide local anesthetic widely studied for its pharmacological and electrophysiological properties It inhibits ATP-sensitive potassium (KATP) channels particularly SUR2A/Kir6 2 as demonstrated in COS-7 cell models where inhibition is concentration-dependent and reversible Reported IC50 values for SUR2A/Kir6 2 SUR2B/Kir6 1 SUR2B/Kir6 2 and Kir6 2 C36 channels are 249 11 2235 115 2442 132 and 2375 179 M respectively Additionally ropivacaine hydrochloride monohydrate suppresses sarcolemmal KATP channels in cardiovascular tissues via stereoselective and tissue-specific mechanisms supporting its utility in studies of ion channel pharmacology and cardiovascular safety profiles
Medchemexpress LLC (+)-Mepivacaine | 24358-84-7 | 99.7% | 5 MG
(+)-Mepivacaine is the optically active (+)-enantiomer of the local anesthetic mepivacaine supplied as a research-grade reagent for studies of sodium channel function, membrane physiology, and neuropharmacology.
- High purity: 99.7%.
- Chemical formula: C15H22N2O.
- Molecular weight: 246.35 g/mol.
- Pack size: 5 mg.
- Recommended storage: -20°C (powder); in solvent -80°C for long-term storage.
Medchemexpress LLC HY-15259A 5mg Medchemexpress, CP-640186 (hydrochloride) CAS:591778-70-0 Purity:>98%
Medchemexpress, HY-15259A 5mg CP-640186 (hydrochloride) CAS:591778-70-0 CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261615.png-250.jpg)
Medchemexpress LLC 1-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | 2160546-07-4 | 100.0% | C17H18Cl2N6 | 10MG
IACS-13909 is a selective, potent, orally active allosteric inhibitor of SHP2 (PTPN11) used as a research compound to probe MAPK pathway signaling and antitumor activity in RTK-dependent models. It provides defined potency, high supplied purity, and solubility/formulation data to support in vitro and in vivo pharmacology studies.
- Selective SHP2 allosteric inhibitor with IC50 15.7 nM and Kd 32 nM.
- High supplied purity (99.97%) suitable for biological assays.
- Soluble in DMSO at 10 mg/mL for in vitro use, with in vivo formulation options.
- Available in multiple solid and solution pack sizes for flexible dosing.
- Applicable to cellular and preclinical pharmacology studies of MAPK pathway signaling.
Medchemexpress LLC HY-108361 10mg Medchemexpress, CCG-203971 CAS:1443437-74-8 Purity:>98%
Medchemexpress, HY-108361 10mg CCG-203971 CAS:1443437-74-8 CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen Ropivacaine
Chemical. CAS 84057-95-4. Formula C17H26N2O. MW 274.4. Synthetic. Ropivacaine is a long-acting amide local anaesthetic agent. Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. It is a pure S-enantiomer and less lipophilic than racemic sodium channel blockers, such as bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity.
Selleck Chemical LLC Nelfinavir Mesylate S4282-10mM/1mL
Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM
Medchemexpress LLC Avibactam sodium hydrate | 2938989-90-1 | 99.6% | 305.24 g/mol | C7H12N3NaO7S | 10 MG
Avibactam sodium hydrate is a covalent, reversible, non-β-lactam β-lactamase inhibitor provided for research and analytical applications. It is used in enzyme inhibition assays and antibiotic resistance studies to characterize inhibition of class A and related β-lactamases.
- Covalent and reversible non-β-lactam β-lactamase inhibitor.
- Inhibits TEM-1 (IC50 = 8 nM) and CTX-M-15 (IC50 = 5 nM).
- CAS number 2938989-90-1.
- Chemical formula C7H12N3NaO7S; molecular weight 305.24 g/mol.
- Purity 99.6%.
- Available as solids (5 mg-1 g) and prepared solution (10 mM x 1 mL).
- Supplied with supporting documents: data sheet, COA, SDS, H NMR, RP-HPLC.
- Intended for research use; follow SDS for handling and storage.
Medchemexpress LLC 1,2-pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2R)- | 400626-71-3 | MFCD14635665 | 250mg
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
Apexbio Technology LLC Nelfinavir 159989-64-7 10mM (in 1mL Ethanol)
Nelfinavir is a selective inhibitor of HIV-1 protease which is responsible for cleaving viral precursor proteins into functional units essential for HIV replication By disrupting this proteolytic step nelfinavir inhibits viral maturation and subsequent infectivity In biochemical assays nelfinavir demonstrates inhibitory activity against HIV-1 protease with an IC50 value typically ranging from 2 to 10 nM Due to its defined mechanism of action nelfinavir is commonly utilized in biomedical research focusing on HIV pathogenesis including antiviral activity studies viral resistance profiling and therapeutic combination assessments in vitro and in cell-based experimental models
Medchemexpress LLC 1,2-pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2R)- | 400626-71-3 | MFCD14635665 | 10g
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
Apexbio Technology LLC Ropivacaine HCl 98717-15-8 10mM (in 1mL H2O)
Ropivacaine HCl (CAS 98717-15-8) is a local anesthetic agent commonly employed in biomedical research to examine neuronal function and signal transmission Mechanistically ropivacaine hydrochloride acts by reversibly blocking the influx of sodium ions across neuronal membranes thereby inhibiting the conduction of nerve impulses Due to this mode of action it serves as a useful pharmacological tool in studies designed to elucidate pain signaling pathways sodium channel behavior and peripheral nerve function
eMolecules Medchem Express / IPSU / 5mg / 446263520 / HY-13796 / / 1373765-19-5 / MFCD25976654 / 405.502 / C23H27N5O2
Medchem Express / IPSU / 5mg / 446263520 / HY-13796 / / 1373765-19-5 / MFCD25976654 / 405.502 / C23H27N5O2