Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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5,641 – 5,655 of 178,220 results

5,641

Medchemexpress LLC MEDCHEMEXPRESS LLC

5000377773 LSD1-IN-30 5MG

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5,642

Medchemexpress LLC N-deacetyl-N-formylcolchicine | 7411-12-3 | 385.41 | 25 MG

N-Deacetyl-N-formylcolchicine is a selective inhibitor targeting the colchicine-binding site of tubulin. It demonstrates antiproliferative activity against various cancer cell lines. This compound inhibits microtubule polymerization, blocking cell division, inducing cancer cell apoptosis, and suppressing migration, showing promise for research in cancers like lung cancer and various solid tumors.

Selective inhibitor targeting the colchicine-binding site of tubulin
Demonstrates antiproliferative activity against various cancer cell lines
Inhibits microtubule polymerization
Blocks cell division
Induces cancer cell apoptosis
Suppressing cell migration
Shows promise for research in lung cancer and various solid tumors

Pricing & Availability

5,643

Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 5 MG

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and is intended for research use only.

Potent PRMT5 inhibitor (IC50 7.5 μM)
Exhibits anti-tumor activities
Higher efficacy in inhibiting cancer cells
Low toxicity in normal cells
Strongly inhibits colony-forming ability in PANC1 and HT29 cells
Inhibits NF-κB activation and target gene expression
Dramatically decreases TNFα and IL8 expression

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5,644

Medchemexpress LLC mTOR inhibitor WYE-28 | 1062172-60-4 | MFCD16661023 | 99.3% | 586.64 g·mol⁻1 | C30H34N8O5 | 1 MG

mTOR inhibitor WYE-28 is a potent, selective small-molecule inhibitor of mTOR used for cell signaling and oncology research. It demonstrates sub-nanomolar mTOR inhibition and is supplied as a high-purity solid in milligram quantities with recommended storage conditions for research use.

Sub-nanomolar mTOR inhibition (IC50 = 0.08 nM) demonstrated in biochemical assays.
Additional activity against PI3Kα (IC50 = 6 nM), useful for pathway profiling.
High purity solid, suitable for cell-based assays and mechanistic studies.
Available in small milligram sizes for early-stage research and screening.
Powder storage: -20°C (up to 3 years); stock solutions: -80°C (6 months) or -20°C (1 month).

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5,645

Aobchem AOBCHEM

5001029401 5-BROMO-2-ETHOXYPYRIDINE-3-BOR

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5,646

Aobchem AOBCHEM

5001029483 2-BROMO-3-CHLOROPYRIDINE-4-BOR

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5,647

Medchemexpress LLC DDAO 10mM 1mL | 118290-05-4 | 308.16 g/mol | C15H11Cl2NO2 | 1 ML

DDAO is a near-infrared red fluorescent probe used as a fluorogenic substrate and calibration standard in fluorescence and enzyme-activity assays. It is offered as a solid and as a ready-to-use 10 mM solution in DMSO for applications requiring long-wavelength emission and sensitive detection.

Near-infrared red fluorescence with excitation around 600-650 nm and emission ~656-658 nm.
High purity suitable for assay calibration and fluorescence labeling.
Available as a solid or as a 10 mM solution in DMSO for immediate use.
Soluble in DMSO; handle and store protected from light to preserve activity.
Widely used for detecting enzyme activities such as β-galactosidase and esterases.

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5,648

Apexbio Technology LLC SNX-2112 908112-43-6 100mg

SNX-2112 (CAS 908112-43-6) is a potent synthetic inhibitor of heat shock protein 90 (Hsp90) exhibiting an IC50 of 30 nM against its target Hsp90 a molecular chaperone broadly expressed in cells assists in the folding and stabilization of various client proteins including kinases and transcription factors implicated in cancer such as Bcr-Abl EGFR and c-Met SNX-2112 disrupts Hsp90 function leading to the degradation of client proteins and subsequent inhibition of signaling pathways essential for tumor cell survival In cancer cell models SNX-2112 has demonstrated cell growth inhibition (e g A-375 IC50 1 25 M) and induces apoptosis and cell cycle arrest This compound is widely used in preclinical studies to investigate Hsp90-dependent oncogenic processes and potential therapeutic strategies

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5,649

Apexbio Technology LLC LAQ824 (NVP-LAQ824,Dacinostat) 404951-53-7 50mg

LAQ824 (NVP-LAQ824 Dacinostat CAS 404951-53-7) is a synthetic derivative of 4-aminomethylcinnamic hydroxamic acid that functions as a histone deacetylase (HDAC) inhibitor It exhibits potent HDAC inhibition with an IC50 of 0 03 M LAQ824 has demonstrated the ability to inhibit proliferation across a range of human cancer cell lines including colorectal (H1299 HCT116) breast (MDA435 SKBR-3 BT-474 MB-468) prostate (DU145 PC3) and non-small cell lung (A549) cancer models with IC50 values below 1 M Additionally it induces apoptosis in breast cancer cells and suppresses multiple myeloma cell growth in a time- and dose-dependent manner LAQ824 is widely utilized in cancer research to study epigenetic regulation and evaluate HDAC inhibitor-based therapeutic strategies

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5,650

Apexbio Technology LLC Tedizolid 856866-72-3 50mg

Tedizolid (CAS 856866-72-3) is a small-molecule inhibitor targeting bacterial 50S ribosomal subunit and human monoamine oxidase (MAO) It inhibits bacterial protein synthesis by binding to the 50S subunit preventing formation of the functional 70S initiation complex Tedizolid exerts its biological activity primarily through inhibition of protein synthesis and MAO In in vitro studies tedizolid demonstrates antibacterial activity against gram-positive pathogens with an MIC50 of approximately 0 5 g/ml against MRSA and inhibits MAO-A and MAO-B with IC50 values of 8 7 M and 5 7 M respectively Based on these pharmacological properties tedizolid holds research potential in antimicrobial resistance studies and investigations of oxazolidinone pharmacodynamics

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5,651

Apexbio Technology LLC TTP 22 329907-28-0 10mM (in 1mL DMSO)

TTP 22 (CAS 329907-28-0) is a potent ATP-competitive inhibitor of casein kinase 2 (CK2) exhibiting an IC50 of 0 1 M and a Ki of 40 nM CK2 is a constitutively active serine/threonine kinase involved in the phosphorylation of a broad array of cellular substrates influencing diverse signaling pathways implicated in oncogenesis inflammation and viral infections Kinetic analyses attribute TTP 22 s high affinity for CK2 to its thieno[2 3-d]pyrimidin-4-ylthio carboxylic acid moiety which competitively binds the ATP pocket In vitro profiling indicates notable selectivity for CK2 over several other kinase families TTP 22 serves as a valuable tool compound for investigating CK2-mediated cellular processes in disease research

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5,652

Apexbio Technology LLC XL388 1251156-08-7 50mg

XL388 (CAS 1251156-08-7) is a selective orally bioavailable inhibitor of mammalian target of rapamycin (mTOR) It exhibits potent activity against both mTOR complexes displaying an IC50 of 9 9 nM for mTOR kinase inhibition In cell-based assays XL388 blocks mTORC1-dependent phosphorylation of p70S6K (IC50 94 nM) and mTORC2-dependent phosphorylation of AKT (IC50 350 nM) in MCF-7 cells leading to reduced proliferation of hematological tumor cell lines and enhanced chemosensitivity In vivo once-daily oral administration of XL388 significantly suppresses tumor growth in several xenograft models with pronounced inhibition observed in MCF-7 xenografts It is valuable for investigating mTOR pathway modulation in cancer research

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5,653

Medchemexpress LLC WDR91-IN-1 | 2759614-35-0 | 98.9% | 372.85 | 25 MG

WDR91-IN-1 (Compd 1) is a first-in-class small-molecule ligand for WDR91, with a KD of 6 μM.

First-in-class small-molecule ligand for WDR91
KD of 6 μM

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5,654

Medchemexpress LLC Aβ1-42 aggregation inhibitor 1 | 2439107-75-0 | 468.66 | 10 MG

Aβ1-42 aggregation inhibitor 1 inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase) with IC50 values of 2.64 μM and 1.29 μM, respectively. This inhibitor reduces self-mediated Aβ1-42 aggregation by 51.29% at a concentration of 25 μM, indicating its potential for anti-Alzheimer's disease research. Additionally, it can selectively form ligand-Cu2+ complexes with Cu2+ at 25 μM within 30 minutes.

Inhibits AChE (acetylcholinesterase) and BuChE (butyrylcholinesterase)
Reduces self-mediated Aβ1-42 aggregation
Potential for research into anti-Alzheimer's disease
Selectively forms ligand-Cu2+ complexes with Cu2+

Pricing & Availability

5,655

Medchemexpress LLC Beta-Glucocerebrosidase modulator 1 | 3080715-77-8 | 99.0% | 366.43 | 10 MG

β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase. It exhibits an EC50 of 9.0 μM and a Kd of 0.050 μM. This product is a light yellow to yellow oil and is intended for research use only.

Allosteric modulator for β-Glucocerebrosidase
EC50 of 9.0 μM
Kd of 0.050 μM
For research use only
Appearance: Light yellow to yellow oil

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Pyridines and derivatives

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Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-deacetyl-N-formylcolchicine | 7411-12-3 | 385.41 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC mTOR inhibitor WYE-28 | 1062172-60-4 | MFCD16661023 | 99.3% | 586.64 g·mol⁻1 | C30H34N8O5 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DDAO 10mM 1mL | 118290-05-4 | 308.16 g/mol | C15H11Cl2NO2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC SNX-2112 908112-43-6 100mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC LAQ824 (NVP-LAQ824,Dacinostat) 404951-53-7 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Tedizolid 856866-72-3 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC TTP 22 329907-28-0 10mM (in 1mL DMSO) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC XL388 1251156-08-7 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC WDR91-IN-1 | 2759614-35-0 | 98.9% | 372.85 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Aβ1-42 aggregation inhibitor 1 | 2439107-75-0 | 468.66 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Beta-Glucocerebrosidase modulator 1 | 3080715-77-8 | 99.0% | 366.43 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More