Pyridines and derivatives
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5000383163 BIPERIDEN 25MG
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Apexbio Technology LLC Repotrectinib 1802220-02-5 10mg
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Repotrectinib (CAS 1802220-02-5) is a macrocyclic small molecule inhibitor of tyrosine kinases developed to overcome resistance mechanisms in non-small cell lung cancer (NSCLC) mediated by ROS1 gene mutations Its compact structure enables selective inhibition of both wild-type and solvent-front mutated ROS1 including the G2032R variant frequently associated with resistance to first-generation TKIs such as crizotinib Repotrectinib has demonstrated robust clinical activity in the TRIDENT-1 study with an objective response rate of 79% in TKI-naive and 38% in TKI-pretreated ROS1-positive NSCLC patients It serves as a valuable tool for investigating mechanisms of kinase inhibitor resistance in oncogenic ROS1-driven cancers
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Medchemexpress LLC Ocadusertib | 2382811-41-6 | 99.6% | 459.50 g·mol⁻¹ | C25H25N5O4 | 10 MG
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Ocadusertib is a potent, selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) supplied as a high-purity small-molecule research compound for biochemical and cell-based studies. It blocks RIPK1-mediated necroptosis and inflammatory cell death and has demonstrated anti-necroptosis activity in TNFα-induced mouse L929 cells (EC50 < 1 nM).
- Selective RIPK1 inhibitor mechanism of action.
- Demonstrated anti-necroptosis activity (EC50 < 1 nM) in TNFα-induced L929 cells.
- High purity: 99.57%.
- Molecular weight 459.50 g·mol⁻¹ and formula C25H25N5O4.
- Provided in small quantities for preclinical in vitro and cell-based assays.
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Apexbio Technology LLC Bazedoxifene HCl 198480-56-7 10mg
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Bazedoxifene HCl (198480-56-7) is a non-steroidal selective estrogen receptor modulator (SERM) targeting estrogen receptor subtypes ER and ER It is designed to bind ERs thereby modulating estrogen receptor-mediated signaling pathways Bazedoxifene HCl exerts its biological activity primarily by antagonizing ER -mediated transcriptional activity thereby inhibiting estradiol-induced cell proliferation In cell-based studies Bazedoxifene HCl demonstrates inhibition of cell proliferation in human breast cancer (MCF-7) ovarian (CHO) hepatic (HepG2) and neuronal (GT1-7) cell lines The compound exhibits binding affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene HCl holds research potential in osteoporosis and estrogen receptor-mediated diseases including breast ovarian and uterine cancers
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Medchemexpress LLC Anti-Mouse Human pho 10mg | 10mg
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Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407 6G12) is a mouse-derived IgG2a type antibody inhibitor targeting to mouse/human phosphorylated PD-1/CD279 Anti-Mouse/Human phosphorylated PD-1/CD279 Antibody (407 6G12) can detect the phosphorylated form of the PD-1 ITSM by both western blot and flow cytometry[1]
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Apexbio Technology LLC PF-431396 717906-29-1 10mg
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PF-431396 is a pyrimidine-based small-molecule inhibitor targeting proline-rich tyrosine kinase 2 (Pyk2) and focal adhesion kinase (FAK) It is designed to selectively inhibit these kinases thereby modulating signaling pathways involved in cellular adhesion migration and proliferation PF-431396 exerts its biological activity primarily through disruption of Pyk2 and FAK tyrosine autophosphorylation or transphosphorylation Based on these pharmacological properties PF-431396 holds research potential in the investigation of cancer biology inflammation and immunological cell responses in experimental models
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Medchemexpress LLC Hdac-in-55 | 1268674-16-3 | 98.4% | 311.34 g/mol | C17H17N3O3 | 10 MG
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HDAC-IN-55 is a small-molecule histone deacetylase (HDAC) inhibitor (CAS 1268674-16-3) reported to increase E-cadherin expression and inhibit cancer cell proliferation. It is provided as a research-grade compound for in vitro and preclinical studies; molecular weight 311.34 g/mol and chemical formula C17H17N3O3.
- Increases E-cadherin expression and inhibits cancer cell proliferation in reported studies.
- Research-grade purity (98.4%) suitable for biochemical and cellular assays.
- High solubility in DMSO (100 mg/mL); ultrasonic agitation recommended.
- Stable as a powder under low-temperature storage (powder: -20°C for long-term).
- Intended for in vitro and preclinical research use only.
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![Medchemexpress LLC 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione | 39674-97-0 | MFCD00616487 | 98.4% | 241.24 g·mol⁻¹ | C14H11NO3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000213849.png-250.jpg)
Medchemexpress LLC 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione | 39674-97-0 | MFCD00616487 | 98.4% | 241.24 g·mol⁻¹ | C14H11NO3 | 10 MG
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BVT948 is a small-molecule research compound that inhibits protein tyrosine phosphatases (PTPs) and shows activity against multiple cytochrome P450 isoforms and the lysine methyltransferase SETD8 (KMT5A). It is supplied as a solid for biochemical and cell-based assays and is typically provided in small research pack sizes for laboratory use.
- Inhibits protein tyrosine phosphatases (PTPs).
- Shows activity against several cytochrome P450 isoforms.
- Inhibits lysine methyltransferase SETD8 (KMT5A).
- Supplied as a solid, soluble in DMSO for assay preparation.
- Available in small research pack sizes suitable for preclinical studies.
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Medchemexpress LLC hDHODH-IN-13 | 3032611-13-2 | 100.0% | 393.84 g·mol⁻¹ | C21H17ClFN5 | 10 MG
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hDHODH-IN-13 is a small-molecule inhibitor of human dihydroorotate dehydrogenase (hDHODH) used in research applications such as inflammatory bowel disease (IBD) models and DHODH biology studies. The compound shows an IC50 of 173.4 nM against hDHODH, has molecular formula C21H17ClFN5, molecular weight 393.84 g·mol⁻¹, and CAS number 3032611-13-2. It is supplied with high stated purity and is available in small research-scale pack sizes suitable for biochemical and cell-based assays.
- Inhibits human dihydroorotate dehydrogenase with low-nanomolar potency.
- Suitable for biochemical and cell-based assays.
- Supplied with high stated purity (99.97%).
- Available in multiple small-pack sizes, including 10 mg.
- Useful for research into inflammatory bowel disease and DHODH biology.
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Apexbio Technology LLC 2-Cl-IB-MECA 163042-96-4 10mg
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2-Cl-IB-MECA is a small-molecule agonist targeting the adenosine A3 receptor (A3AR) It is designed to selectively activate A3AR thereby regulating cellular processes such as inflammation modulation and cytoprotection 2-Cl-IB-MECA exerts its biological activity primarily through activation of A3AR-mediated signaling pathways Based on these pharmacological properties 2-Cl-IB-MECA holds research potential in chronic inflammatory responses tissue remodeling hepatic fibrosis oncology and inflammatory disorder contexts and is commonly used to evaluate receptor-mediated biochemical pathways in in vitro cellular models and experimental animal studies
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