Pyridines and derivatives
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Filtered Search Results
Apexbio Technology LLC PF 1022A 133413-70-4 10mM (in 1mL DMSO)
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PF 1022A (CAS 133413-70-4) is a cyclodepsipeptide exhibiting anthelmintic activity targeting latrophilin-like transmembrane receptors and nematode GABA receptor pathways It acts by interacting with these receptors affecting pharyngeal muscle activity in nematodes and modulating mammalian proteins such as p53 bax and p21 thereby impacting cell cycle regulation and apoptosis PF 1022A primarily exerts its biological activity as an ionophore facilitating ion transport across membranes In livestock experimental models PF 1022A demonstrates anthelmintic effects at doses of 1 10 mg/kg though precise IC50 values have not been established Based on these characteristics PF 1022A holds research potential in veterinary nematode control and as a tool for studying cell cycle regulation and apoptosis in vascular smooth muscle disease
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Cayman Chemical Onalespib Inhibitors
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A selective inhibitor of Hsp90 (IC50 = 18 nM); induces the degradation of specific Hsp90 client proteins; efficacious in a range of xenograft models
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Medchemexpress LLC Trans-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one | 1363421-46-8 | 99.0% | 100 MG
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MOMIPP is a small-molecule PIKfyve inhibitor that induces macropinocytosis and methuosis in cultured cells, and is reported to penetrate the blood-brain barrier. It is used as a research tool to study endosomal trafficking, macropinocytosis-related cell death, and PIKfyve-mediated signaling.
- Inhibits PIKfyve and induces macropinocytosis leading to methuosis.
- Penetrates the blood-brain barrier, enabling central nervous system studies.
- Active in low micromolar ranges in cell-based assays.
- Molecular formula C18H16N2O2; molecular weight 292.33 g·mol⁻¹.
- Supplied with high purity (99.0%) and available in multiple pack sizes including 100 mg.
- Stable as powder at -20°C for extended storage; store solutions at -80°C for long-term.
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Medchemexpress LLC Avenanthramide C | 116764-15-9 | MFCD23380831 | 98.9% | 315.28 g/mol | C16H13NO6 | 50MG
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Avenanthramide C is a naturally occurring avenanthramide isolated from oat (Avena sativa) and used in research for its antioxidant and anti-inflammatory properties. Supplied as a research-grade reference standard in a 50 mg solid form, it is suitable for biochemical, cellular, and analytical applications. Key chemical attributes include CAS 116764-15-9, molecular formula C16H13NO6, molecular weight 315.28 g/mol, and typical purity 98.9%.
- High purity 98.9% as tested by supplier.
- Supplied as a 50 mg solid for small-scale experiments.
- Suitable for biochemical and cellular assays.
- Known antioxidant and anti-inflammatory activity.
- Characterized by CAS 116764-15-9 and molecular weight 315.28 g/mol.
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Medchemexpress LLC Romaciclib hydrochloride | 1609452-30-3 | MFCD31692363 | 99.8% | 450.6 g/mol | C15H19Br2ClN4 | 5 MG
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Romaciclib hydrochloride is the hydrochloride salt of romaciclib, a potent, selective inhibitor of cyclin-dependent kinases CDK8 and CDK19 intended for preclinical biochemical and cellular research. Supplied as a high-purity solid in small laboratory quantities, it is provided with storage recommendations for both solid and solution forms.
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Cayman Chemical ML9 Inhibitors
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An inhibitor of PKB/Akt activity (IC50 = 10-50 µM) that inhibits insulin-stimulated glucose transport and intracellular protein translocation; inhibits additional serine/threonine kinases including PKA (IC50 = ~20 µM), p90 S6 (IC50 = ~50 µM), and MAP kinase (IC50 = ~35 µM)
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Medchemexpress LLC FKBP12 PROTAC dTAG-7 | 2064175-32-0 | 99.5% | 1210.32 | C63H79N5O19 | 5MG
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FKBP12 PROTAC dTAG-7 is a heterobifunctional PROTAC degrader that engages FKBP12F36V and recruits the CRBN E3 ligase to induce rapid, selective degradation of target proteins. It is supplied as a high-purity solid for research use in cellular and in vivo studies, with documented solubility and storage recommendations to support experimental planning.
- Heterobifunctional PROTAC that targets FKBP12F36V and recruits CRBN.
- Enables rapid, selective degradation of target proteins in cells and in vivo.
- High purity (≈99.5%) solid with off-white to light yellow appearance.
- Molecular weight 1210.32 and chemical formula C63H79N5O19 for dosing calculations.
- Soluble in DMSO at ≥100 mg/mL; in vivo formulations documented for common vehicles.
- Store solid at -20°C; solutions stable at -80°C for long-term storage.
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Medchemexpress LLC Recombinant human NCAM1 (CD56) protein | 97.6% | 5 UG
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Recombinant human NCAM-1 (CD56) is a mammalian-expressed extracellular adhesion protein supplied as a 0.22 μm filtered PBS solution with a C-terminal His tag. It is provided at high purity and concentration for use in biochemical assays, antibody validation, and studies of cell-surface interactions, with recommended long-term storage at -80 °C.
- Expressed in HEK293 mammalian cells for native glycosylation.
- C-terminal His tag for detection and purification.
- Supplied as a 0.22 μm filtered PBS solution, pH 7.4.
- High purity by reducing SDS-PAGE (>95%).
- Provided at approximately 1.98 mg/mL concentration.
- Store at -80 °C; shipped on dry ice, avoid repeated freeze-thaw.
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Apexbio Technology LLC AT13148 1056901-62-2 50mg
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AT13148 (CAS 1056901-62-2) is an orally bioavailable ATP-competitive inhibitor targeting multiple AGC family kinases including AKT (IC50 38 nM) p70S6 kinase (IC50 8 nM) PKA (IC50 3 nM) SGK (IC50 63 nM) and Rho kinase (IC50 4 nM) In vitro AT13148 suppresses AGC kinase activity and inhibits proliferation in various human cancer cell lines with GI50 values ranging from 1 54 M to 3 77 M In vivo studies demonstrate its antitumor efficacy in human xenograft models such as PTEN-deficient MES-SA uterine sarcoma and HER2-positive PIK3CA-mutant BT474 breast cancer This molecule is valuable for investigating AGC kinase signaling and tumor biology
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![Medchemexpress LLC 3-(2-phenylethynyl)-2-[2-(1-pyrrolidinyl)ethoxy]-pyrido[2,3-b]pyrazine | 1025015-40-0 | 99.9% | 344.41 g/mol | C21H20N4O | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238537.png-250.jpg)
Medchemexpress LLC 3-(2-phenylethynyl)-2-[2-(1-pyrrolidinyl)ethoxy]-pyrido[2,3-b]pyrazine | 1025015-40-0 | 99.9% | 344.41 g/mol | C21H20N4O | 25MG
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GK921 is a small-molecule inhibitor of transglutaminase 2 (TGase2) with an IC50 of 7.71 μM against human recombinant TGase2. It is provided as a high-purity solid or as a DMSO solution for laboratory research (CAS 1025015-40-0).
- Inhibitory activity: IC50 = 7.71 μM against human recombinant TGase2.
- Purity: ≈99.9%.
- Chemical formula: C21H20N4O; molecular weight: 344.41 g/mol.
- Physical form: solid powder or 10 mM solution in DMSO.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 2 years) or -20°C (up to 1 year).
- Intended use: for research use only; not for human use.
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Medchemexpress LLC 1-benzyl-3-(4-methoxyanilino)-4-phenylpyrrole-2,5-dione | 264206-85-1 | 99.2% | 384.43 g/mol | C24H20N2O3 | 50MG
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GSK3987 is a pan LXRα/β agonist research compound used to study cholesterol metabolism and lipogenesis. It increases expression of ABCA1 and SREBP-1c, promotes cellular cholesterol efflux, and can induce triglyceride accumulation. Supplied for laboratory research use only, the compound is supported by a certificate of analysis and product documentation.
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Medchemexpress LLC CD206/MMR Human HE 50ug | 50ug
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The CD206/MMR protein acts as a multifunctional mediator in macrophages promoting glycoprotein internalization It has a broad binding capacity interacting with both sulfated and non-sulfated polysaccharide chains CD206/MMR Protein Human (HEK293 His) is the recombinant human-derived CD206/MMR protein expressed by HEK293 with C-His labeled tag
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BIOHIPPO GRE-TAR-Puro LV
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GRE-TAR-Puro is a transcription factor reporter lentiviral vector designed to monitor glucocorticoid response element GRE pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
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Medchemexpress LLC (RS)-CPPG | 183364-82-1 | 99.0% | 271.21 g/mol | C11H14NO5P | 5 MG
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CPPG ((RS)-CPPG) is a research-grade antagonist of group II and III metabotropic glutamate receptors used in pharmacology and neuroscience studies. It is a white solid with high purity, molecular formula C11H14NO5P, molecular weight 271.21 g/mol, and CAS number 183364-82-1. Store powdered material at -20°C for long-term stability.
- High purity suitable for research applications.
- Selective antagonist of group II and III mGlu receptors.
- Powder form facilitates storage and formulation.
- Stable under recommended storage conditions.
- Suitable quantities for screening and assay work.
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BIOHIPPO FXRE-TAG-Puro LV
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FXRE-TAG-Puro is a transcription factor reporter lentiviral vector designed to monitor FXR response element bile acid signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
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