Pyridines and derivatives
Apexbio Technology LLC Tasisulam 519055-62-0 50mg
Tasisulam (CAS 519055-62-0) is a small-molecule anticancer agent that induces apoptosis and modulates tumor vasculature Its activity involves generation of reactive oxygen species reduction of mitochondrial membrane potential G2-M phase arrest and inhibition of angiogenesis via growth factor pathways In vitro Tasisulam inhibits proliferation induces apoptosis and promotes differentiation in hematopoietic cancer cell lines In endothelial cells it suppresses angiogenesis mediated by EGF VEGF and FGF pathways In xenograft models it causes tumor growth inhibition G2-M arrest apoptosis and vascular modulation These properties highlight its potential in oncology research particularly for studies on apoptosis and tumor vascular regulation
Apexbio Technology LLC Tasisulam 519055-62-0 10mg
Tasisulam (CAS 519055-62-0) is a small-molecule anticancer agent that induces apoptosis and modulates tumor vasculature Its activity involves generation of reactive oxygen species reduction of mitochondrial membrane potential G2-M phase arrest and inhibition of angiogenesis via growth factor pathways In vitro Tasisulam inhibits proliferation induces apoptosis and promotes differentiation in hematopoietic cancer cell lines In endothelial cells it suppresses angiogenesis mediated by EGF VEGF and FGF pathways In xenograft models it causes tumor growth inhibition G2-M arrest apoptosis and vascular modulation These properties highlight its potential in oncology research particularly for studies on apoptosis and tumor vascular regulation
Apexbio Technology LLC Rosiglitazone HCl 302543-62-0 100mg
Rosiglitazone HCl (CAS 302543-62-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor gamma (PPAR ) It is designed to selectively activate PPAR thereby modulating gene transcription involved in glucose metabolism adipogenesis and insulin sensitivity Rosiglitazone HCl exerts its biological activity primarily through activation of PPAR receptors expressed in adipocytes Based on these pharmacological properties Rosiglitazone HCl holds research potential in diabetes mellitus metabolic syndrome obesity and associated metabolic disorders
Apexbio Technology LLC ML 228 1357171-62-0 100mg
ML 228 (CAS 1357171-62-0) is a small molecule that stimulates the hypoxia-inducible factor (HIF) signaling pathway by chelating iron through a mechanism independent of prolyl hydroxylase domain (PHD) enzymes It enhances HIF pathway activity with EC sub 50 /sub values of 1 23 M in HRE gene reporter assays and 1 4 M for HIF-1 nuclear translocation At 10 M ML 228 also demonstrates greater than 80% inhibition of the human A sub 3 /sub adenosine receptor dopamine transporter opioid receptor hERG channel 5-HT sub 2B /sub receptor and rat sodium channel site 2 ML 228 is valuable for studies investigating HIF pathway regulation hypoxia response and off-target pharmacological profiling in cellular models
Apexbio Technology LLC ML 228 1357171-62-0 5mg
ML 228 (CAS 1357171-62-0) is a small molecule that stimulates the hypoxia-inducible factor (HIF) signaling pathway by chelating iron through a mechanism independent of prolyl hydroxylase domain (PHD) enzymes It enhances HIF pathway activity with EC sub 50 /sub values of 1 23 M in HRE gene reporter assays and 1 4 M for HIF-1 nuclear translocation At 10 M ML 228 also demonstrates greater than 80% inhibition of the human A sub 3 /sub adenosine receptor dopamine transporter opioid receptor hERG channel 5-HT sub 2B /sub receptor and rat sodium channel site 2 ML 228 is valuable for studies investigating HIF pathway regulation hypoxia response and off-target pharmacological profiling in cellular models
TARGETMOL CHEMICALS INC 22393-62-0-peak 2 1MG
Also available in 5 mg and bulk. Please contact Fisher for quotes. 22393-62-0-peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatology. Purity 98.71%
Apexbio Technology LLC ML 228 1357171-62-0 50mg
ML 228 (CAS 1357171-62-0) is a small molecule that stimulates the hypoxia-inducible factor (HIF) signaling pathway by chelating iron through a mechanism independent of prolyl hydroxylase domain (PHD) enzymes It enhances HIF pathway activity with EC sub 50 /sub values of 1 23 M in HRE gene reporter assays and 1 4 M for HIF-1 nuclear translocation At 10 M ML 228 also demonstrates greater than 80% inhibition of the human A sub 3 /sub adenosine receptor dopamine transporter opioid receptor hERG channel 5-HT sub 2B /sub receptor and rat sodium channel site 2 ML 228 is valuable for studies investigating HIF pathway regulation hypoxia response and off-target pharmacological profiling in cellular models
Apexbio Technology LLC ML 228 1357171-62-0 10mg
ML 228 (CAS 1357171-62-0) is a small molecule that stimulates the hypoxia-inducible factor (HIF) signaling pathway by chelating iron through a mechanism independent of prolyl hydroxylase domain (PHD) enzymes It enhances HIF pathway activity with EC sub 50 /sub values of 1 23 M in HRE gene reporter assays and 1 4 M for HIF-1 nuclear translocation At 10 M ML 228 also demonstrates greater than 80% inhibition of the human A sub 3 /sub adenosine receptor dopamine transporter opioid receptor hERG channel 5-HT sub 2B /sub receptor and rat sodium channel site 2 ML 228 is valuable for studies investigating HIF pathway regulation hypoxia response and off-target pharmacological profiling in cellular models
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 50mg
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 10mg
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Medchemexpress LLC ML228 | 1357171-62-0 | 98.0% | 10 MG
ML228 is a potent Hypoxia Inducible Factor (HIF) pathway activator with an EC50 of 1 μM. It potently activates HIF in vitro as well as its downstream target VEGF. ML228 represents a novel chemotype for the study of HIF activation and its therapeutic potential.
- Potently activates HIF in vitro
- Activates downstream target VEGF
- Novel chemotype for HIF activation studies
- Structurally different from known HIF activators
- Lacks acidic functional group found in PHD inhibitors
- Improves local hypoxic ischemia environment in vivo
- Reduces SCI secondary injury in vivo
- Promotes recovery of neurological function in SD rats
Medchemexpress LLC Tezacaftor | 1152311-62-0 | C26H27F3N2O6 | 1 ML
Tezacaftor is a F508del CFTR corrector that aids the CFTR protein in reaching the cell surface. When combined with Ivacaftor, a CFTR potentiator, it exhibits potent efficacy against cystic fibrosis and diseases involving homozygosity for the CFTR Phe508del mutation. The combination of Elexacaftor-Tezacaftor-Ivacaftor is intended for individuals with cystic fibrosis (CF) who have at least one Phe508del mutation, often helping them avoid the need for lung transplantation. It is suitable for laboratory research and manufacture of substances.
- Aids CFTR protein in reaching the cell surface
- Exhibits potent efficacy against cystic fibrosis
- Intended for individuals with cystic fibrosis with at least one Phe508del mutation
- Supports laboratory research
- Used in the manufacture of substances
Medchemexpress LLC Tezacaftor | 1152311-62-0 | C26H27F3N2O6 | 100 MG
Tezacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector that assists CFTR protein in reaching the cell surface. When combined with a CFTR potentiator, it demonstrates strong effectiveness against cystic fibrosis and diseases involving a homozygous CFTR mutation. Another corrector, when combined with tezacaftor and a potentiator, targets cystic fibrosis with at least one specific mutation, often helping to avoid the need for lung transplantation.
- Helps protein reach the cell surface.
- Increases protein expression levels in specific cells.
- Shows potent efficacy against certain genetic conditions when combined with other compounds.
- Can improve clinical outcomes in patients with specific mutations.
- Aids in prolonging the opening time of cell surface protein channels when used with a potentiator.
Medchemexpress LLC Paclobutrazol | 76738-62-0 | 97.1% | 1 G
Paclobutrazol is a triazole-containing plant growth retardant and an analytical standard. It is known for its ability to inhibit the biosynthesis of gibberellins and exhibits antifungal activities. This compound is transported acropetally in plants, where it can suppress the synthesis of abscisic acid, leading to induced chilling tolerance. It is primarily used in research to investigate the role of gibberellins in plant biology.
- Inhibits the biosynthesis of gibberellins
- Possesses antifungal properties
- Can suppress abscisic acid synthesis
- Induces chilling tolerance in plants
- Used as an analytical standard
- Valuable tool for research on plant biology
Medchemexpress LLC Paclobutrazol | 76738-62-0 | 97.1% | 1 ML
Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. It also has antifungal activities, can suppress the synthesis of abscisic acid, and induces chilling tolerance in plants. Transported acropetally, it is typically used to support research on the role of gibberellins in plant biology.
- Inhibits biosynthesis of gibberellins
- Possesses antifungal activities
- Suppresses synthesis of abscisic acid
- Induces chilling tolerance in plants
- Used for research on gibberellins in plant biology
- Functions as a triazole-containing plant growth retardant
- Transported acropetally in plants