Pyridines and derivatives
Medchemexpress LLC Muscone | 541-91-3 | 238.41 | 25 MG
Muscone is the primary active monomer found in traditional Chinese medicine musk. It functions by inhibiting NF-κB and NLRP3 inflammasome activation. Muscone has been shown to significantly reduce the levels of inflammatory cytokines (IL-1β, TNF-α, and IL-6), leading to improved cardiac function and increased survival rates.
- Main active monomer of traditional Chinese medicine musk.
- Inhibits NF-κB and NLRP3 inflammasome activation.
- Remarkably decreases levels of inflammatory cytokines (IL-1β, TNF-α, and IL-6).
- Improves cardiac function and survival rate.
- Downregulates LPS-induced inflammatory cytokines in bone marrow-derived macrophages (BMDMs) in vitro.
- Considered a promising drug for post-myocardial infarction (MI) treatment.
Medchemexpress LLC Muscone | 541-91-3 | 238.41 | 1 ML
Muscone is identified as the primary active monomer derived from traditional Chinese medicine musk. It functions by inhibiting NF-κB and NLRP3 inflammasome activation, leading to a significant reduction in inflammatory cytokines such as IL-1β, TNF-α, and IL-6. This action ultimately contributes to improved cardiac function and increased survival rates.
- Inhibits NF-κB activation
- Inhibits NLRP3 inflammasome activation
- Decreases inflammatory cytokines (IL-1β, TNF-α, and IL-6)
- Improves cardiac function
- Increases survival rate
Medchemexpress LLC Isovaleramide (3-Methylbutanamide) | 541-46-8 | 98.0% | 1 ML
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant that inhibits alcohol dehydrogenase (ADH) activity and regulates the GABAergic system. It reduces acute kidney injury and has antiepileptic, anxiolytic, sedative, and hypnotic effects.
- Orally active anticonvulsant
- Inhibits alcohol dehydrogenase (ADH) activity
- Regulates GABAergic system
- Reduces acute kidney injury
- Antiepileptic effects
- Anxiolytic effects
- Sedative effects
- Hypnotic effects
Medchemexpress LLC Isovaleramide (3-Methylbutanamide) | 541-46-8 | 98.0% | 100 MG
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. It inhibits alcohol dehydrogenase (ADH) activity and regulates the GABAergic system. It reduces acute kidney injury and has antiepileptic, anxiolytic, sedative, and hypnotic effects.
- Orally active anticonvulsant
- Inhibits alcohol dehydrogenase (ADH) activity
- Regulates the GABAergic system
- Reduces acute kidney injury
- Antiepileptic effects
- Anxiolytic effects
- Sedative effects
- Hypnotic effects
Apexbio Technology LLC Carvedilol 72956-09-3 25g
Carvedilol is an antagonist targeting 1- and -adrenergic receptors employed in research on cardiovascular diseases especially congestive heart failure and hypertension Mechanistically carvedilol blocks adrenergic receptor-mediated signaling influencing sympathetic nervous system activity Additionally carvedilol exhibits antioxidative properties in vitro studies demonstrate suppression of Fe2 -induced lipid peroxidation (IC50 8 1 M) protection of -tocopherol depletion due to Fe2 exposure (IC50 17 6 M) and reduction of hydroxyl radical-derived DMPO-OH signals (IC50 25 M) It also inhibits proliferation (IC50 0 3-2 0 M) and migration (IC50 3 M) in vascular smooth muscle cells induced by platelet-derived growth factor supporting investigation of vascular remodeling processes
Apexbio Technology LLC INCB024360 analogue 914471-09-3 50mg
INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
Apexbio Technology LLC INCB024360 analogue 914471-09-3 5mg
INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
Medchemexpress LLC GW3965 100mg | 405911-09-3 | 100MG
GW3965 is a potent selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXR and hLXR respectively[1 [2 [3
Medchemexpress LLC CATPB 1mg | 1322598-09-3 | 1 MG
CATPB is a potent, selective antagonist of free fatty acid receptor 2 (FFA2/GPR43) intended for research use. It is supplied as a white to off-white solid with high purity and defined storage conditions, provided in a 1 mg quantity.
- Potent, selective antagonist of FFA2 (GPR43)
- Molecular formula C19H17ClF3NO3; molecular weight 399.79
- Purity 99.7%
- Appearance: white to off-white solid
- Storage: powder -20°C for long term; 4°C for short term
- Intended for research use only
Medchemexpress LLC Apatorsen | 915443-09-3 | 98.5% | 10MG
Apatorsen sodium is a second-generation antisense oligonucleotide that binds Hsp27 mRNA and inhibits Hsp27 protein production. It is supplied as a sequence-modified oligonucleotide (2'-O-(2-methoxyethyl) and phosphorothioate chemistries) in sodium salt form for research applications.
- Targets Hsp27 mRNA to reduce Hsp27 protein expression.
- Sequence-modified chemistry enhances nuclease resistance and binding affinity.
- Supplied as a sodium salt suitable for in vitro research.
- High reported purity for experimental consistency (~98.5%).
- Useful for studying Hsp27 biology and antisense therapeutic mechanisms.
Medchemexpress LLC DS28120313 5mg | 2146177-09-3 | 5MG
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0 093 M[1
Medchemexpress LLC Carvedilol | 72956-09-3 | 99.98% | 1 ML
Carvedilol is a non-selective β/α-1 blocker. It inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. This multiple-action antihypertensive agent has potential use in angina and congestive heart failure. It also acts as an autophagy inducer that inhibits the NLRP3 inflammasome.
- Non-selective β/α-1 blocker.
- Inhibits lipid peroxidation with an IC50 of 5 μM.
- Antihypertensive agent for angina and congestive heart failure.
- Autophagy inducer.
- Inhibits the NLRP3 inflammasome.
- Inhibits superoxide generation by activated human neutrophils (IC50 of 28 μM).
- Scavenges oxygen free radicals in a cell-free system (IC50 of 25 μM).
Medchemexpress LLC Filanesib | 885060-09-3 | C20H22F2N4O2S | 100 MG
Filanesib is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor with an IC50 of 6 nM for human KSP. It induces cell death by apoptosis in vitro and has potent anti-proliferative activity.
- Induces mitotic arrest in multiple cell lines.
- Exhibits anti-proliferative activity against a broad range of human and rodent tumor cell lines.
- Induces apoptosis in a dose-dependent manner in HeLa cells.
- Causes accumulation of cells in the G2/M phase of the cell cycle in HeLa cells.
- Potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway.
- Able to induce caspase-2 activation.
- Cytotoxic in Type II EOC cells.
- Demonstrates anti-tumor activity in vivo.
Medchemexpress LLC JNJ-42041935 | 1193383-09-3 | 99.8% | 10 MG
JNJ-42041935 is a potent, competitive, and selective inhibitor of prolyl hydroxylase (PHD) enzymes, including PHD1, PHD2, and PHD3. It has shown effectiveness in reversing inflammation-induced anemia in rats and increasing reticulocytes, hemoglobin, and hematocrit in in vivo studies.
- Potent, competitive, and selective inhibitor of prolyl hydroxylase
- Inhibits PHD1, PHD2, and PHD3
- Most potent inhibitor of PHD2181-417
- Effectively reverses inflammation-induced anemia in rats
- Increases reticulocytes, hemoglobin, and hematocrit in vivo
Medchemexpress LLC JNJ-42041935 | 1193383-09-3 | 99.8% | 100 MG
JNJ-42041935 is described as a potent, competitive, and selective inhibitor of prolyl hydroxylase (PHD), demonstrating inhibition of PHD1, PHD2, and PHD3 with specific pKi values. It has been investigated for its efficacy in reversing inflammation-induced anemia in rat models and for increasing reticulocytes, hemoglobin, and hematocrit in vivo.
- Potent inhibition of specific enzymes.
- Competitive and selective mode of action.
- Effective in reversing anemia in preclinical models.
- Increases red blood cell precursors, hemoglobin, and hematocrit in animal studies.