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Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.
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1

6-Phenyl-2-thiouracil 98.0+%, TCI America™

CAS: 36822-11-4 Molecular Formula: C10H8N2OS Molecular Weight (g/mol): 204.247 MDL Number: MFCD00059166 InChI Key: XEKNACRTWJHOCE-UHFFFAOYSA-N PubChem CID: 697057 IUPAC Name: 6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one SMILES: C1=CC=C(C=C1)C2=CC(=O)NC(=S)N2

PubChem CID 697057
CAS 36822-11-4
Molecular Weight (g/mol) 204.247
MDL Number MFCD00059166
SMILES C1=CC=C(C=C1)C2=CC(=O)NC(=S)N2
IUPAC Name 6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
InChI Key XEKNACRTWJHOCE-UHFFFAOYSA-N
Molecular Formula C10H8N2OS
2

Apexbio Technology LLC GNF 2 778270-11-4 5mg
SDP

GNF 2 (CAS 778270-11-4) is a small-molecule inhibitor targeting Bcr-Abl kinase It is designed to suppress Bcr-Abl-mediated signaling thereby regulating leukemic cell proliferation GNF 2 exerts its biological activity primarily through non-ATP competitive allosteric inhibition at the myristate-binding pocket of Abl In cell-based studies GNF 2 demonstrates inhibitory activity with an IC50 of approximately 138 nM in Ba/F3 p210 cells expressing wild-type Bcr-Abl It also inhibits mutant Bcr-Abl forms (E255V Y253H) and proliferation of K562 and SUP-B15 human leukemia cell lines with IC50 values of 194 273 nM Based on these pharmacological properties GNF 2 holds research potential in chronic myeloid leukemia (CML) pathogenesis and therapeutic response studies involving Bcr-Abl fusion proteins

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3

Medchemexpress LLC 4-Ethylphenylacetylene | 40307-11-7 | 98.11% | 130.19 | 100 G
SDP

1-Ethyl-4-ethynylbenzene is a biochemical reagent suitable for life science research as a biological material or organic compound. It functions as a click chemistry reagent, featuring an Alkyne group that can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.

  • Biochemical reagent for life science research.
  • Click chemistry reagent.
  • Contains an alkyne group for CuAAc reactions.

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4

Medchemexpress LLC Ethyl 11-dodecenoate | 76063-06-4 | 226.36 | 25 MG
SDP

Ethyl 11-dodecenoate is a liquid laboratory chemical designed for research use. It is stable under recommended storage conditions and has a molecular weight of 226.36.

  • Stable under recommended storage conditions
  • Designed for laboratory use
  • Requires proper handling and storage
  • Not a hazardous substance or mixture according to GHS classification

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5

Medchemexpress LLC GNF-2 | 778270-11-4 | 99.8% | 374.32 | 10 MG
SDP

GNF-2 | 778270-11-4 | 99.8% | 374.32 | 10 MG

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6

Medchemexpress LLC 1-Ethyl-4-ethynylbenzene | 40307-11-7 | 98.11% | 130.19 | 25 G
SDP

1-Ethyl-4-ethynylbenzene is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

  • Used as a biological material or organic compound for life science research.
  • Functions as a click chemistry reagent.
  • Contains an Alkyne group.
  • Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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7

Medchemexpress LLC Ethyl 11-dodecenoate | 76063-06-4 | >99.0% | 226.36 g/mol | C14H26O2 | 10 MG
SDP

Ethyl 11-dodecenoate is the ethyl ester of 11-dodecenoic acid (CAS 76063-06-4), provided as a small-quantity research reagent for synthetic and analytical use. It has formula C14H26O2 and molecular weight 226.36 g/mol. Store cold under inert atmosphere to maintain stability.

  • Ethyl ester of 11-dodecenoic acid (C14H26O2).
  • Molecular weight 226.36 g/mol.
  • Available in small research pack sizes, including 10 mg.
  • Suitable for synthetic chemistry and analytical applications.
  • Store at -20°C under nitrogen; in solvent: -80°C for 6 months or -20°C for 1 month.

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8

Medchemexpress LLC PSMA-11 (HBED-CC-PSMA) | 1366302-52-4 | 99.7% | 946.99 | C44H62N6O17 | 10MG
SDP

PSMA-11 (HBED-CC-PSMA) is a PSMA-targeting ligand used as a precursor for radiolabeled PET tracers. Supplied as a white to off-white solid, it is intended for radiolabeling with gallium-68 or other radionuclides for preclinical and research PET imaging of PSMA-expressing prostate cancer. The compound's high purity and chelator-conjugated design support efficient tracer preparation and consistent labeling performance.

  • PSMA-targeting ligand for PET tracer development.
  • Contains HBED-CC chelator for efficient radiolabeling.
  • High purity (99.7%) suitable for radiolabeling applications.
  • Supplied as a solid for synthesis and formulation workflows.
  • Available in multiple pack sizes to suit research needs.
  • Used for preclinical imaging of PSMA-expressing tumors.

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9

eMolecules​ 7-Methylpyrazolo[1,5-a][1,3,5]triazin-4(3H)-one | 55457-11-9 | MFCD11870778 | 1g

Ambeed | 7-Methylpyrazolo[1,5-a][1,3,5]triazin-4(3H)-one | 1g | 591797706 | A166405 | | 55457-11-9 | MFCD11870778 | 150.141 | C6H6N4O

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10

eMolecules​ Medchem Express / GNF-2 / 5mg / 446259752 / HY-11007 / / 778270-11-4 / MFCD09265253 / 374.323 / C18H13F3N4O2

Medchem Express / GNF-2 / 5mg / 446259752 / HY-11007 / / 778270-11-4 / MFCD09265253 / 374.323 / C18H13F3N4O2

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11

Medchemexpress LLC 2-Ethyl-3-hydroxy-4H-pyran-4-one (Standard) | 4940-11-8 | 100.0% | 140.14 | 250 MG
SDP

Ethyl maltol (Standard) serves as an analytical standard for research and analytical applications. This compound, also known as 2-Ethyl-3-hydroxy-4H-pyran-4-one, is an orally active and significant food additive and flavor enhancer. It has been observed to be less toxic to rats and dogs.

  • Intended for research and analytical applications
  • Functions as an orally active food additive and flavor enhancer
  • Less toxic to rats and dogs
  • Enhances copper-mediated cytotoxicity
  • Induces apoptosis in lung epithelial cells
  • Solid appearance
  • Color: white to off-white

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12

Medchemexpress LLC Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) | 4940-11-8 | 100.0% | 140.14 | 1 ML
SDP

Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells.

  • Orally active.
  • Important food additive.
  • Flavor enhancer.
  • Less toxic to rats and dogs.
  • Can enhance copper-mediated cytotoxicity.
  • Can induce apoptosis in lung epithelial cells.
  • Induces cell apoptosis and leads to oxidative stress and DNA damage in copper treated lung epithelial cells.
  • Increases pATM phosphorylation level.
  • Increases the expression of ferritin light chain and hemeoxygenase.
  • Safe in rats and dogs.
  • Toxicity is less than the homolog maltol.

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13

Medchemexpress LLC 5H-dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- | 2369979-67-7 | MFCD34167518 | 99.5% | C19H20ClFN4 | 10MG
SDP

JHU37152 is a potent, brain-penetrant DREADD agonist selective for hM3Dq and hM4Di receptors. In HEK-293 assays it exhibits EC50s of 5 nM (hM3Dq) and 0.5 nM (hM4Di), displaces [3H]clozapine, and is supplied as a high-purity research reagent.

  • High purity: 99.45%.
  • Cas number: 2369979-67-7.
  • Chemical formula: C19H20ClFN4.
  • Molecular weight: 358.84 g·mol⁻1.
  • Physical state: solid, white to yellow.
  • Solubility: soluble in DMSO (~33.33 mg/mL).
  • Storage: powder -20°C for long term; in solvent -80°C recommended.
  • Applications: in vitro and in vivo neuroscience research.

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14

Medchemexpress LLC 8-chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e]diazepine | 2369979-67-7 | 99.5% | 358.84 g/mol | C19H20ClFN4 | 5 MG
SDP

A brain-penetrant DREADD agonist research compound with low-nanomolar activity at engineered muscarinic receptors. It demonstrates selective displacement of radioligand binding in brain tissue and is supplied as a high-purity solid or as ready-to-use DMSO solutions for research applications. For research use only; not for human or clinical use.

  • Potent agonist at hM3Dq (EC50 ≈ 5 nM) and hM4Di (EC50 ≈ 0.5 nM).
  • Brain-penetrant with selective displacement of [3H]clozapine binding in brain tissue.
  • High purity solid (≈99.5%) and available as 10 mM DMSO solutions for convenience.
  • Suitable for in vivo and in vitro DREADD activation and imaging studies.
  • Provided for research use only; not intended for human or clinical applications.

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15

eMolecules​ Ambeed / [2-(Amino-N)[11-biphenyl]-2-yl-C][[5-(diphenylphosphino)-99-dimethyl-9H-xanthen-4-yl]diphenylphosphine-P](methanesulfonato-O)palladium / 100mg / 490535788 / A214875 / / 1445085-97-1 / [null] / 948.360 / C52H45NO4P2PdS

Ambeed / [2-(Amino-N)[11-biphenyl]-2-yl-C][[5-(diphenylphosphino)-99-dimethyl-9H-xanthen-4-yl]diphenylphosphine-P](methanesulfonato-O)palladium / 100mg / 490535788 / A214875 / / 1445085-97-1 / [null] / 948.360 / C52H45NO4P2PdS

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