Pyrroles
Medchemexpress LLC Entasobulin | 501921-61-5 | 98.5% | 439.89 | 50 MG
Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. It is an indolizine-glyoxylamide based small molecule that demonstrates substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes.
- Inhibits β-tubulin polymerization
- Shows potential anticancer activity
- Demonstrates substantial in vitro anti-proliferative activities against cancer cell lines
- Effective against multidrug resistance (MDR) phenotypes
- For research use only
Medchemexpress LLC Pevonedistat | 905579-51-3 | 99.98% | C21H25N5O4S | 200 MG
Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. It acts by inducing deregulation of S-phase DNA synthesis, which disrupts protein turnover mediated by cullin-RING ligase, ultimately leading to apoptosis in human tumor cells. It also suppresses the growth of human tumor xenografts in mice.
- Potent and selective NEDD8-activating enzyme (NAE) inhibitor
- Induces deregulation of S-phase DNA synthesis
- Disrupts protein turnover mediated by cullin-RING ligase
- Promotes apoptosis of human tumor cells
- Suppresses tumor xenograft growth in mice
eMolecules 213743-31-8 | Medchem Express | RK-24466 | 5mg | 437899035 | HY-108318 | MFCD04974490 | 370.456 | C23H22N4O
ChemScene | (S)-2-Amino-5-(isopropylamino)-5-oxopentanoic acid | 250mg | 628857491 | CS-0186170 | 4311-12-0 | MFCD00672360 | 188.227 | C8H16N2O3
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Medchemexpress LLC 5-hydroxy-3-(indol-3-yl)isoindolin-1-one (S-isomer) | 2375482-51-0 | 99.5% | 516.59 Da | C31H28N6O2 | 50MG
BI-2852 is a small-molecule inhibitor that binds the KRAS switch I/II pocket and inhibits active, GTP-bound KRAS with nanomolar potency. It is intended for research use and is used as a tool compound to study KRAS-driven signaling, pERK modulation, and antiproliferative effects in KRAS-mutant cell models.
- Potent nanomolar inhibition of KRAS switch I/II pocket.
- Directly targets active GTP-bound KRAS to disrupt effector interactions.
- Suitable for in vitro studies of KRAS signaling and cell proliferation.
- High purity (>99%) suitable for biochemical and cell-based assays.
- Molecular formula C31H28N6O2 and molecular weight 516.59 Da.
- Available with supporting documentation, including COA and SDS.
Medchemexpress LLC HY-101971 10mg Medchemexpress, AZ PFKFB3 26 CAS:1704740-52-2 Purity:>98%
Medchemexpress, HY-101971 10mg AZ PFKFB3 26 CAS:1704740-52-2 AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]- | 60142-89-4 | HY-W012001 | >=98.0% | 245.32 | 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000454000-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]- | 60142-89-4 | HY-W012001 | >=98.0% | 245.32 | 100 G
N-Boc-7-aminoheptanoic acid is a PROTAC linker used in the synthesis of PROTACs and other conjugation applications. It features an alkane chain with terminal carboxylic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators like EDC or HATU to form a stable amide bond, and the Boc group can be deprotected under mild acidic conditions to yield the free amine.
- Utilized as a PROTAC linker
- Suitable for PROTAC synthesis
- Suitable for other conjugation applications
- Features an alkane chain with terminal carboxylic acid and Boc-protected amino groups
- Carboxylic acid reacts with primary amines for stable amide bond formation
- Boc group deprotects under mild acidic conditions to yield free amine
Selleck Chemical LLC Osimertinib
Osimertinib (AZD9291) is an oral irreversible and mutant-selective EGFR inhibitor with IC50 of 12 92 11 44 and 493 8 nM for Exon 19 deletion EGFR L858R/T790M EGFR and WT EGFR in LoVo cells respectively Phase 3
eMolecules 96-54-8 | N-methylpyrrole | Combi-Blocks | MFCD00005345 | 81.118 | C5H7N | 98.000 | Cn1cccc1 | 5g | 290686257
N-methylpyrrole | Combi-Blocks | 96-54-8 | MFCD00005345 | 81.118 | C5H7N | 98.000 | Cn1cccc1 | 5g | 290686257
Medchemexpress LLC HY-18935A 5mg Medchemexpress, CBL0137 hydrochloride CAS:1197397-89-9 Purity:>98%
Medchemexpress, HY-18935A 5mg CBL0137 hydrochloride CAS:1197397-89-9 CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Ribociclib
Ribociclib is an orally available and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM Phase 3
Medchemexpress LLC JMS-17-2 | 1380392-05-1 | MFCD30489012 | 99.2% | 419.95 | C25H26ClN3O | 50MG
JMS-17-2 is a small-molecule research compound that functions as a potent and selective antagonist of the CX3CR1 receptor (IC50 = 0.32 nM). It has been used in preclinical studies to impair metastatic seeding and colonization of breast cancer cells. The material is supplied as a high-purity solid with recommended cold storage for prepared solutions to preserve stability.
- Chemical formula: C25H26ClN3O.
- Molecular weight: 419.95 g·mol-1.
- High purity suitable for research use.
- Appearance: white to off-white solid.
- Storage: store solid at 4°C protected from light; store solutions at -20°C to -80°C for longer-term stability.
- Applications: in vitro and in vivo studies of CX3CR1-mediated processes and metastasis models.
- Available in multiple pack formats including small mg quantities and ready-to-use DMSO solutions.
Selleck Chemical LLC LLY-507-5mg
LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.
Medchemexpress LLC EX229, a benzimidazole derivative | 1219739-36-2 | MFCD31696597 | 99.4% | 431.87 | C24H18ClN3O3 | 5 MG
EX229 is a benzimidazole-derived small-molecule allosteric activator of AMP-activated protein kinase (AMPK) used for biochemical and cellular research. It binds AMPK complexes with submicromolar affinity and shows potent cellular activity, suitable for pathway and metabolic studies.
- Potent allosteric activator of AMPK (Kd ≈ 0.06 μM for primary complexes).
- Demonstrated cellular activity (EC50 ≈ 3 nM in Sf21 cell assay).
- High purity (≈99.4%).
- Soluble in DMSO (~13 mg/mL) with recommended in vivo formulation protocols.
- Stable as powder and in solvent when stored under recommended conditions.
- Available in small-mass packs and DMSO solutions for screening workflows.
Medchemexpress LLC HY-119933 10mg Medchemexpress, RIPK1-IN-7 CAS:2300982-44-7 Purity:>98%
Medchemexpress, HY-119933 10mg RIPK1-IN-7 CAS:2300982-44-7 RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.