Pyrroles
Medchemexpress LLC Atorvastatin | 134523-00-5 | 99.6% | 10 MM X 1 ML
Atorvastatin is an orally active HMG-CoA reductase inhibitor that effectively decreases blood lipids. It inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
- Acts as an HMG-CoA reductase inhibitor
- Effectively decreases blood lipids
- Inhibits human SV-SMC proliferation
- Inhibits human SV-SMC invasion
Medchemexpress LLC (3S,5S)-Atorvastatin | 501121-34-2 | 95.0% | 1 ML
(3S,5S)-Atorvastatin is an inactive enantiomer of Atorvastatin. It can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, which effectively decreases blood lipids. This product is for research use only and not sold to patients.
- Increases CYP2B and CYP3A mRNA content with equal ability as Atorvastatin.
- Induces luciferase activity with an EC50 of 12.4 μM at 100 μM concentrations.
- Addition to FPBA/l-tryptophanol mixture induces intensity enhancement of l-tryptophanol fluorescence.
Medchemexpress LLC (3S,5S)-Atorvastatin | 501121-34-2 | 95.0% | 50 MG
(3S,5S)-Atorvastatin is an inactive enantiomer of Atorvastatin that activates pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, known for its ability to effectively decrease blood lipids.
- Increases CYP2B and CYP3A mRNA content with equal ability as Atorvastatin.
- Induces luciferase activity with an EC50 of 12.4 μM at 100 μM concentrations.
- Addition to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture enhances l-tryptophanol fluorescence.
Medchemexpress LLC Pipemidic acid trihydrate | 72571-82-5 | 98.0% | 357.36 | 25 MG
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. It inhibits DNA gyrase and is active against gram-negative bacteria, including Pseudomonas aeruginosa, as well as some gram-positive bacteria. It can be used for the research of intestinal, urinary, and biliary tract infections.
- Derivative of piromidic acid
- Antibacterial agent
- Inhibits DNA gyrase
- Active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria
- Can be used for the research of intestinal, urinary, and biliary tract infections
Selleck Chemical LLC Sacubitril hemicalcium salt S4426-1g
Sacubitril (AHU-377) hemicalcium salt a component of the heart failure medicine LCZ696 is a potent inhibitor of neprilysin (neutral endopeptidase NEP)
Medchemexpress LLC Atorvastatin methyl ester | 345891-62-5 | MFCD21363420 | 98.8% | C34H37FN2O5 | 10MG
Atorvastatin methyl ester is a methyl-esterified derivative of atorvastatin provided for laboratory research. It is used as a drug derivative and has been reported to inhibit 9-cis-RA-induced Gal4 reporter activity more strongly than atorvastatin. The compound is supplied as solids and as a DMSO solution for in vitro experiments.
- Methyl-esterified derivative of atorvastatin used for research
- Reported to inhibit 9-cis-RA-induced Gal4 reporter activity more strongly than atorvastatin
- Available as solid quantities (10 mg-500 mg) and 10 mM solution in DMSO
- High purity (approx. 98.8%) suitable for in vitro studies
- Useful structural analogue for metabolism and activity studies
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 10mM (in 1mL DMSO)
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Biotium Malate dehydrogenase 1 NAD (soluble)(CPTC-MDH1-1), CF740 conjugate, 0.1mg/mL
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Medchemexpress LLC Almotriptan (malate) | 181183-52-8 | 99.5% | 5 MG
Almotriptan (malate) | 181183-52-8 | 99.5% | 5 MG
Apexbio Technology LLC Bromoenol lactone 88070-98-8 5mg
Bromoenol lactone (CAS 88070-98-8) is an irreversible inhibitor of cytosolic calcium-independent phospholipase A2 (iPLA2) an enzyme involved in the regulation of arachidonic acid release and lysophospholipid production iPLA2 activity is associated with phospholipid remodeling and the generation of signaling molecules that modulate processes such as eicosanoid synthesis insulin secretion apoptosis and cellular proliferation In cellular assays bromoenol lactone induces apoptosis in various cell lines and promotes proteolysis of procaspase-9 and procaspase-3 It also inhibits phosphatidic acid phosphohydrolase activity and disrupts triacylglycerol biosynthesis in macrophage models Bromoenol lactone is widely utilized in studies investigating lipid signaling cell death mechanisms and metabolic pathways
Medchemexpress LLC N-desethyl sunitinib | 356068-97-8 | 99.9% | 370.42 | 50 MG
N-Desethyl Sunitinib (SU-12662) is a metabolite of Sunitinib. It functions as a good transport substrate for human ABCB1, ABCG2, and murine ABCG2. This compound is provided as a solution in DMSO.
- Metabolite of sunitinib
- Acts as a good transport substrate for human ABCB1 and ABCG2
- Functions as a good transport substrate for murine ABCG2
- Provided in DMSO solution
TARGETMOL CHEMICALS INC Atorvastatin hemicalcium salt
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol. Purity 99.89%
Selleck Chemical LLC Sacubitril hemicalcium salt S4426-100mg
Sacubitril (AHU-377) hemicalcium salt a component of the heart failure medicine LCZ696 is a potent inhibitor of neprilysin (neutral endopeptidase NEP)