Pyrrolidines
Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.3% | 369.54 | 50 MG
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM.
- Modulates effects of 2-arachidonyl glycerol (2-AG) by increasing endogenous levels of 2-AG in the brain
- Prevents cerebellar membrane-mediated degradation of 2-AG
- Produces dose-dependent hypothermia when combined with 2-AG
- Inhibits locomotor activity when combined with 2-AG
- Causes antinociception when combined with 2-AG
- Induces catalepsy when combined with 2-AG
Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.3% | 369.54 | 100 MG
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM. It is a putative MAGL inhibitor that modulates the effects of 2-arachidonyl glycerol (2-AG), increasing endogenous levels of 2-AG in the brain and preventing cerebellar membrane-mediated degradation of 2-AG.
- Modulates the effects of 2-arachidonyl glycerol (2-AG)
- Increases endogenous levels of 2-AG in the brain
- Prevents cerebellar membrane-mediated degradation of 2-AG
- For research purposes only
Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.31% | 369.54 | 10 MG
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM. It modulates the effects of 2-arachidonyl glycerol (2-AG) by increasing endogenous levels of 2-AG in the brain and preventing cerebellar membrane-mediated degradation of 2-AG.
- Potent, irreversible inhibitor of monoacylglycerol lipase (MAGL)
- Modulates effects of 2-arachidonyl glycerol (2-AG)
- Increases endogenous levels of 2-AG in the brain
- Prevents cerebellar membrane-mediated degradation of 2-AG
- Produces hypothermia, inhibition of locomotor activity, antinociception, and catalepsy in vivo
Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.31% | 369.54 | 25 MG
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM. It can be used to modulate the effects of 2-arachidonyl glycerol (2-AG) by increasing its endogenous levels in the brain, and it prevents cerebellar membrane-mediated degradation of 2-AG.
- Potent, irreversible MAGL inhibitor
- Modulates effects of 2-arachidonyl glycerol (2-AG)
- Increases endogenous levels of 2-AG in the brain
- Prevents cerebellar membrane-mediated degradation of 2-AG
Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.3% | 369.54 | 1 ML
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM. It modulates the effects of 2-arachidonyl glycerol (2-AG) by increasing its endogenous levels in the brain and preventing cerebellar membrane-mediated degradation.
- Potent and irreversible monoacylglycerol lipase (MAGL) inhibitor
- Modulates effects of 2-arachidonyl glycerol (2-AG)
- Increases endogenous levels of 2-AG in the brain
- Prevents cerebellar membrane-mediated degradation of 2-AG
- Induces hypothermia, antinociception, and catalepsy in vivo when combined with 2-AG
Selleck Chemical LLC Ivosidenib
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity
Medchemexpress LLC 1-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-1H-pyrrole-2,5-dione | 876305-42-9 | MFCD11521506 | 98.3% | 369.54 | C24H35NO2 | 5 MG
N-Arachidonyl maleimide is an irreversible inhibitor of monoacylglycerol lipase (MAGL) used in research to modulate endocannabinoid signaling by increasing 2-arachidonyl glycerol (2-AG) levels. It inhibits MAGL with an IC50 of 140 nM and has been characterized for preventing cerebellar membrane-mediated degradation of 2-AG. The compound is supplied in solid and solution formats for biochemical and cellular studies.
- Irreversible MAGL inhibitor with reported IC50 of 140 nM.
- Modulates 2-AG levels by inhibiting enzymatic degradation.
- High reported purity (≈98.3%), suitable for research applications.
- Available in multiple pack sizes and a pre-made solution for experimental flexibility.
- Molecular formula C24H35NO2; molecular weight 369.54 g·mol⁻1.
- Commonly used in biochemical assays to study endocannabinoid metabolism.
Medchemexpress LLC HY-18767 10mg Medchemexpress, Ivosidenib CAS:1448347-49-6 Purity:>98%
Medchemexpress, HY-18767 10mg Ivosidenib CAS:1448347-49-6 Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC N6-(2-Hydroxyethyl)adenosine | 4338-48-1 | 311.30 | 100 MG
N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog that inhibits the NF-κB/Smad signaling pathway. It demonstrates various biological activities, including anti-hyperglycemia, antioxidant, antitumor, anti-inflammatory, and insecticidal effects, and is orally active.
- Reduces LPS-induced TNF-α and IL-1β expression
- Increases IL-10 secretion in RAW 264.7 cells
- Reduces TGF-β1-induced expression of collagen I, α-SMA, and fibronectin in NRK-49F cells
- Induces ROS generation and decreases mitochondrial membrane potential
- Exhibits cytotoxicity in SGC-7901 and AGS cancer cells
- Leads to apoptosis and autophagy
- Exhibits insecticidal activity against *Plutella xylostella*
- Reduces blood glucose, serum creatinine, blood urea nitrogen, and urine protein levels in diabetic rats
- Alleviates glomeruli and renal tubule damage
- Reduces tumor volume and weight in SGC-7901 xenograft mouse models