Quinolines and derivatives
![Medchemexpress LLC Naphtho[1,2-d]thiazol-2-ylamine | 40172-65-4 | MFCD00051329 | 99.7% | 200.27 | C11H8N2S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264707.png-250.jpg)
Medchemexpress LLC Naphtho[1,2-d]thiazol-2-ylamine | 40172-65-4 | MFCD00051329 | 99.7% | 200.27 | C11H8N2S | 5 MG
SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine, CAS 40172-65-4) is a research-grade small-molecule activator of calcium-activated potassium channels (KCa2/KCa3.1), used to probe ion channel function and endothelial or neuronal hyperpolarization in vitro and in vivo studies.
- Potent channel activator with KCa3.1 EC50 ~260 nM and KCa2 subtype EC50s in the low micromolar range.
- High purity for research use (≈99.7%).
- Small molecular weight and defined composition: 200.27 g/mol; formula C11H8N2S.
- Soluble in DMSO (≈125 mg/mL) and formulatable for in vivo dosing.
- Supplied as a solid powder suitable for biochemical and cellular assays.
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 100g
Methyl phenyl sulfone is a drug impurity
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 10g
Methyl phenyl sulfone is a drug impurity
Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | MFCD00069218 | 100.0% | 750.70 g/mol | C33H44BrN5O8S | 5 MG
Bromocriptine mesylate is the methanesulfonate salt of bromocriptine, a semisynthetic ergot-derived dopamine D2/D3 receptor agonist used in research. It shows high affinity for D2 receptors (pKi ≈ 8.05) and is provided as both a solid and solution format for laboratory and analytical applications.
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 25g
Methyl phenyl sulfone is a drug impurity
Medchemexpress LLC Act-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 10MG
ACT-1004-1239 is a potent, selective, orally available CXCR7 (ACKR3) antagonist developed as a first-in-class compound. It exhibits low nanomolar potency and has shown immunomodulatory and promyelinating effects in preclinical models and early clinical research.
- Potent CXCR7 antagonism with IC50 3.2 nM.
- Orally bioavailable compound suitable for systemic dosing.
- Demonstrated immunomodulatory and promyelinating activity in vivo.
- High chemical purity and solid, stable formulation for storage.
- Compatible with in vitro and in vivo pharmacology studies.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
![Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243212.png-250.jpg)
Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG
TAK-715 is an orally active, potent p38 MAPK inhibitor used in research to probe p38α signaling and related pathways; it also inhibits casein kinase I (CK1δ/ε) and has demonstrated efficacy in preclinical inflammation models.
- Potent p38α inhibition (IC50 7.1 nM) with reduced activity against p38β (IC50 200 nM).
- Reported inhibition of CK1δ/ε and modulation of Wnt/β-catenin signaling.
- Chemical formula C24H21N3OS; molecular weight 399.51 g/mol.
- High reported purity (99.76%).
- Soluble in DMSO (≈50 mg/mL) with suggested protocols for in vivo formulation.
- Powder stable at -20°C for extended storage; solvent stocks stable at -80°C.
Medchemexpress LLC Q-VD-OPh | 1135695-98-5 | MFCD08669741 | 99.9% | 513.49 g/mol | C26H25F2N3O6 | 10MM 1ML
Q-VD-OPh is an irreversible pan-caspase inhibitor used in research to block apoptosis. It inhibits caspase-7 with an IC50 of approximately 48 nM and shows inhibitory activity against multiple caspases (IC50 25-400 nM). The compound is cell-permeable, reported to cross the blood-brain barrier, and is provided as powder and as DMSO stock solutions for convenient preparation of working concentrations.
- Irreversible pan-caspase inhibitor with low-nanomolar potency against caspase-7.
- Activity against multiple caspases (IC50 range 25-400 nM).
- Cell-permeable and reported to cross the blood-brain barrier.
- Available as powder or pre-prepared DMSO stock for flexible use.
- High purity suitable for research applications (reported 99.9%).
Medchemexpress LLC Pyrroloquinoline quinone disodium salt | 122628-50-6 | 98.0% | 374.17 g/mol | C14H4N2Na2O8 | 50 MG
Pyrroloquinoline quinone disodium salt is the disodium salt form of the redox cofactor PQQ supplied for research and analytical applications. The material is a pink to red solid used in studies of metabolism, oxidative stress, and cellular signaling. It is provided as a small powdered reagent with recommended sealed storage to preserve stability.
- Redox co-factor used in metabolic and oxidative stress research.
- High purity suitable for analytical and biological applications.
- Pink to red solid that is easy to weigh and handle.
- Stable when stored sealed and protected from moisture.
- Available in small powder pack sizes for laboratory use.
Medchemexpress LLC Pyrroloquinoline quinone disodium salt | 122628-50-6 | 98.0% | 374.17 g/mol | C14H4N2Na2O8 | 10 MG
Pyrroloquinoline quinone disodium salt is a water-soluble redox cofactor used as a research reagent in studies of cellular metabolism, mitochondrial function, and oxidative stress. The disodium salt form enhances solubility for aqueous assays and small-scale formulations, and is typically supplied with high purity for experimental reproducibility.
- Water-soluble form suitable for aqueous assays.
- Acts as a redox cofactor for metabolism and mitochondrial studies.
- High purity supports reproducible experimental results.
- Appropriate for biochemical and cell biology applications.
- Available in small quantities for screening and pilot studies.
Medchemexpress LLC Succinimidyl 3-(2-pyridyldithio)propionate | 68181-17-9 | MFCD00009636 | 99.1% | 312.37 g/mol | C12H12N2O4S2 | 200 MG
Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) is a heterobifunctional, cleavable crosslinker that links primary amines to sulfhydryl groups via an NHS ester and a pyridyldithiol moiety, forming a reducible disulfide bond useful for reversible bioconjugation and antibody-drug conjugates.
- Short spacer arm for minimal linker length.
- Reacts with primary amines via an NHS ester.
- Couples to sulfhydryls through a pyridyldithiol group.
- Forms a glutathione-cleavable disulfide bond.
- Suitable for reversible protein conjugation and ADC linker strategies.
- High purity and defined molecular weight for reproducible results.
Medchemexpress LLC Pyrroloquinoline quinone disodium salt | 122628-50-6 | 98.0% | 374.17 g/mol | C14H4N2Na2O8 | 100 MG
Pyrroloquinoline quinone disodium salt is the sodium salt form of PQQ, a redox cofactor used as a research reagent for studies of redox biology and immune function. It is supplied as a pink to red solid with high reported purity and defined storage recommendations.
- High purity: 98.0%.
- Molecular weight: 374.17 g/mol.
- Chemical formula: C14H4N2Na2O8.
- Appearance: pink to red solid.
- Storage: store sealed at 4°C, away from moisture.
- Applications: suitable for redox and immune function research.
Medchemexpress LLC Pyrroloquinoline quinone-13C3 sodium | 72909-34-3 | 99.3% | 421.11 g·mol⁻¹ | C1113C3H2N2Na4O8 | 1 MG
Pyrroloquinoline quinone-13C3 sodium is the 13C3 isotopically labeled sodium salt of pyrroloquinoline quinone, supplied as a high-purity tracer and internal standard for quantitative analytical methods. It is intended for research use in studies of redox chemistry and biological activity, and for method development and validation in mass spectrometry and NMR-based assays.
- Isotopically labeled sodium salt for tracer and internal standard use.
- High purity suitable for quantitative analytical methods.
- Compatible with NMR, GC-MS, and LC-MS workflows.
- Supports studies of redox activity and biological function.
- Supplied in small, weighed quantities for research applications.
eMolecules 1128-61-6 | 6-Fluoro-2-methylquinoline | Accela ChemBio (ASD) | MFCD00041233 | 161.179 | C10H8FN | 98.000 | Cc1ccc2cc(F)ccc2n1 | 5g | 586025070
6-Fluoro-2-methylquinoline | Accela ChemBio (ASD) | 1128-61-6 | MFCD00041233 | 161.179 | C10H8FN | 98.000 | Cc1ccc2cc(F)ccc2n1 | 5g | 586025070
eMolecules 4965-36-0 | 7-Bromoquinoline | Oakwood Chemical | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 1g | 537699225
7-Bromoquinoline | Oakwood Chemical | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 1g | 537699225