Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,046 – 3,060 of 5,484 results

3,046

Medchemexpress LLC CEFSULODIN SODIUM 200 mg

CEFSULODIN SODIUM 200MG

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3,047

Medchemexpress LLC Subtilisin (EC 3.4.21.14) | 9014-01-1 | 200 MG

Subtilisin (EC 3.4.21.14) is a bacterial serine protease produced through deep fermentation, extraction, and purification of *Bacillus subtilis*. It hydrolyzes protein molecules into polypeptides or amino acids and can catalyze polypeptide synthesis in organic solvents. This product contains stabilizers and has observed anticancer and antifouling activities.

Induces apoptosis
Stimulates expression of pro-allergic cytokines (IL-1α, IL-33)
Induces prototypic allergic lung inflammation
Exhibits anticancer activity against breast and colon cancer
Shows antifouling activity
Can be used as a detergent additive
Effective temperature range: 20-60°C (optimum 35-45°C)
Effective pH range: 6.0-11.0 (optimum 9.5-10.5)
Activators: Ca2+, Mg2+, Mn2+, Zn2+, Fe2+
Inhibitors: Reagents acting on serine such as sulfonyl halides

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3,048

Medchemexpress LLC STF-31 | 724741-75-7 | 97.0% | 423.53 | 10 MM 1 ML

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1) with an IC50 of 1 μM. It also functions as a NAMPT inhibitor and inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.

Targets GLUT
Targets Autophagy
Used in cancer research
Cited in over 15 publications

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3,049

TARGETMOL CHEMICALS INC RESIQUIMOD 50MG

Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells macrophages and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines especially interferon-alpha (INF-a) and other cytokines thereby enhancing T-helper 1 (Th1) immune responses. In addition topical application of resiquimod appears to activate Langerhans' cells leading to an enhanced activation of T-lymphocytes. purity: 99%

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3,050

Medchemexpress LLC DTPD-Q | 252950-56-4 | 99.7% | 318.37 | 25 MG

DTPD-Q is a transformation product of the tire additive N,N′-diphenyl-p-phenylenediamine (DTPD). It accumulates and increases ecological risk in the environment.

Inhibits dynamin 1 (IC50 = 273 μM).
Reduces clathrin-mediated endocytosis in serum-starved U2OS cells (IC50 = 120 μM).
Less toxic to the aquatic bacterium V. fischeri than DTPD (EC50 = 1.98 mg/L).
Increases intestinal permeability and the production of reactive oxygen species (ROS) in C. elegans at concentrations of 1 or 10 μg/ml.
Detected in roadway runoff water, roadside soils, indoor dust, and consumer products made from recycled tire rubber.

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3,051

Medchemexpress LLC Iox1 10Mm 1Ml In Dmso | HY-12304

Iox1 10Mm 1Ml In Dmso

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3,052

TARGETMOL CHEMICALS INC DABRAFENIB MESYLATE 100MG

Also available in 5 mg 10 mg 25 mg 50 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf respectively). purity: 99%

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3,053

TARGETMOL CHEMICALS INC O-DESMETHYL QUINIDINE 100MG

Also available in 500 mg and bulk. Please contact Fisher for quotes. O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias. purity: 100%

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3,054

TARGETMOL CHEMICALS INC TBA-7371 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6. purity: 99%

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3,055

TARGETMOL CHEMICALS INC OBATOCLAX MESYLATE 25MG

Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki 0.22 uM) and can induce apoptosis with up-regulation of Bim induced cytochrome c release and activation of caspase-3. purity: 99%

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3,056

Medchemexpress LLC MCC950 sodium | 256373-96-3 | 99.8% | 200 MG

MCC950 sodium is a potent and selective NLRP3 inhibitor with IC50s of 7.5 nM in BMDMs and 8.1 nM in HMDMs. It blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations and specifically inhibits NLRP3 but not AIM2, NLRC4, or NLRP1 activation.

Potent and selective NLRP3 inhibitor
Inhibits IL-1β but not TNF-α secretion
Blocks canonical and non-canonical NLRP3 activation
Specifically inhibits NLRP3 (not AIM2, NLRC4, or NLRP1)
Reduces Interleukin-1β (IL-1β) production
Attenuates severity of experimental autoimmune encephalomyelitis (EAE)
Off-white to yellow solid appearance
Purity of 99.8%

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3,057

Medchemexpress LLC 6PPD-Q | 2754428-18-5 | C18H22N2O2 | 25 MG

6PPD-Q (6PPD-Quinone) is an environmental pollutant detected in human urine and widely present in the environment. It targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 showing the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. It can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. This compound is applicable for research in environmental toxicology, neurodegenerative diseases, and inflammation-related disorders.

Targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1
Acts as a CNR2 receptor agonist
Induces intestinal inflammation and barrier damage
Reduces neuronal glycolysis metabolites and TCA cycle intermediates
Exacerbates α-synuclein (α-syn) aggregation

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3,058

MEDCHEMEXPRESS LLC RESIQUIMOD 10MG

501872943 RESIQUIMOD 10MG

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3,059

Medchemexpress LLC ICARIIN 200 mg

ICARIIN 200MG

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3,060

Apexbio Technology LLC SYRINGALDEHYDE-200MG

Syringaldehyde (CAS No 134-96-3) is a phenolic aldehyde known for its role in the biomedical research category where it originates from the oxidative degradation of lignin a complex polymer found in plant cell walls Its mechanism of action involves modulating oxidative stress pathways and it has shown promising antioxidant properties In vitro syringaldehyde exhibits activity in the nanomolar to low micromolar range Typical applications include its use in cell models for studying cellular oxidative stress responses and in animal studies to evaluate its potential as a therapeutic agent Additionally it is used in drug screening processes particularly for its antioxidant capabilities Experimental concentrations typically depend on the specific research design

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Quinolines and derivatives

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Medchemexpress LLC CEFSULODIN SODIUM 200 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Subtilisin (EC 3.4.21.14) | 9014-01-1 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC STF-31 | 724741-75-7 | 97.0% | 423.53 | 10 MM 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DTPD-Q | 252950-56-4 | 99.7% | 318.37 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Iox1 10Mm 1Ml In Dmso | HY-12304 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MCC950 sodium | 256373-96-3 | 99.8% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 6PPD-Q | 2754428-18-5 | C18H22N2O2 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

MEDCHEMEXPRESS LLC RESIQUIMOD 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC ICARIIN 200 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More