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Filtered Search Results
Medchemexpress LLC Thioridazine | 50-52-2 | MFCD00242875 | 99.5% | 200 MG
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Thioridazine is an antagonist of the dopamine receptor D2 family proteins, exhibiting potent anti-psychotic and anti-anxiety activities. It is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with an anti-angiogenic effect, showing antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity in targeting cancer stem cells (CSCs).
- Reduces cell viability of NCI-N87 and AGS cells
- Reduces cell viability of cervical and endometrial cancer cells
- Induces gastric cancer cell death via the mitochondrial apoptosis pathway
- Modulates cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest
- Inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
- Extends the survival of tumor-bearing mice
- Reduces oral behavior and selectively blocks repetitive head bobbing
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Medchemexpress LLC Idramantone | 20098-14-0 | 99.94% | 200 MG
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Idramantone is an Adamantane derivative and an immunostimulant. It serves as a versatile starting material for synthesizing various adamantine derivatives. It can be produced using P450cam monooxygenase coupled with NADH regeneration as an oxidation biocatalyst and can be studied in research on bronchial pathology.
- Adamantane derivative
- Immunostimulant
- Versatile starting material for synthesizing various derivatives
- Can be produced using P450cam monooxygenase
- Suitable for research on bronchial pathology
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Medchemexpress LLC U0126-EtOH | 1173097-76-1 | 98.9% | 200MG
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U0126-EtOH | 1173097-76-1 | 98.9% | 200MG
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Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | 99.9% | 161.16 | 1 G
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2,8-Quinolinediol, also known as 8-Hydroxy-2(1H)-quinolinone, is a biochemical reagent. It serves as a biological material or organic compound, primarily intended for various life science-related research applications. This product is for research use only and not for medical or patient use.
- Biochemical reagent
- Used as a biological material or organic compound
- Intended for life science research
- Not validated for medical applications
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Apexbio Technology LLC Rocilinostat (ACY-1215) 1316214-52-4 200mg
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Rocilinostat (ACY-1215 CAS 1316214-52-4) is a selective inhibitor of histone deacetylase 6 (HDAC6) HDAC6 enzymatically regulates various cellular processes including protein trafficking cell-cycle progression and cytoskeletal organization and its dysregulated activity is implicated in tumor progression and cancer metastasis Rocilinostat potently inhibits HDAC6 (IC50 5 nM) while showing minimal activity against other HDAC isoforms and sirtuins (IC50 1 M) Preclinical studies using multiple myeloma (MM) cell lines and xenograft mouse models demonstrated rocilinostat can enhance acetylation of -tubulin disrupt protein stability pathways and sensitize cancer cells to proteasome inhibitors such as bortezomib and carfilzomib resulting in increased apoptosis and reduction in tumor growth
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Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 99.0% | C37H48N6O10S3 | 25 MG
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Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. It is used for fluorescence imaging, enabling visualization of PD-L1 in tumors, site-specific modification of anti-PD-L1 antibodies, and RNA labeling. The probe can also be conjugated for imaging in atherosclerosis and breast cancer models.
- Exhibits favorable click chemistry reactivity
- Used for fluorescence imaging of PD-L1 in tumors
- Facilitates site-specific modification of anti-PD-L1 antibodies
- Applied in RNA labeling and imaging
- Can be conjugated for imaging in atherosclerosis and breast cancer models
- Detects ADP-ribosylation events via click chemistry
- Conjugates to alkyne-functionalized TMV coat proteins (CuAAC)
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Apexbio Technology LLC Ki16198 355025-13-7 200mg
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Ki16198 (CAS 355025-13-7) is the methyl ester derivative of Ki16425 and functions as an antagonist of lysophosphatidic acid (LPA) receptors preferentially inhibiting LPA1 and LPA3 receptor subtypes Ki16198 reduces receptor-mediated inositol phosphate production with Ki values of 0 34 M (LPA1) and 0 93 M (LPA3) showing minimal inhibition of LPA2 and no significant activity against LPA4 6 In vitro Ki16198 attenuates LPA-induced proliferation migration invasion and proMMP-9 expression in cancer cells In vivo studies report suppression of pancreatic tumor growth metastasis and ascites formation highlighting its utility in investigating LPA-related cancer progression pathways
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eMolecules 911108-90-2 | 5-HYDROXYQUINOLINE-3-CARBOXYLIC ACID | AstaTech | MFCD18417133 | 189.170 | C10H7NO3 | 95.000 | OC(=O)c1cnc2cccc(O)c2c1 | 1g | 200618597
5-HYDROXYQUINOLINE-3-CARBOXYLIC ACID | AstaTech | 911108-90-2 | MFCD18417133 | 189.170 | C10H7NO3 | 95.000 | OC(=O)c1cnc2cccc(O)c2c1 | 1g | 200618597
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TARGETMOL CHEMICALS INC OROTIRELIN 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Orotirelin(CG 3509) a thyrotropin-releasing hormone analog reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia. purity: 100%
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Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | 99.9% | 434.65 | 1 MG
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Tacalcitol monohydrate can promote normal bone growth by regulating calcium ions. It inhibits cancer cell proliferation and migration and can be used in the research of inflammation, cancer, and skin diseases. This product is for research use only and not sold to patients.
- Purity: 99.85%
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen).
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Apexbio Technology LLC AS 602801 848344-36-5 200mg
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AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions
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Apexbio Technology LLC O4I1 175135-47-4 200mg
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O4I1 (CAS 175135-47-4) is a potent small molecule inducer of Oct3/4 (also known as POU5F1 or Oct4) a transcription factor essential for embryonic stem cell self-renewal and pluripotency O4I1 enhances Oct3/4 expression and stability significantly increasing transcriptional activity in multiple human somatic cell types Treatment of HEK293 cells with O4I1 at 10 M and 20 M for 72 hours resulted in approximately 2 5-fold and 4-fold elevations in Oct3/4 mRNA levels respectively Increased gene and protein expression of Oct3/4 was also observed in human primary and neonatal fibroblast cultures These properties make O4I1 a valuable tool for studying cellular reprogramming and stem cell biology
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Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 200mg, CAS: 896705-16-1.
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BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research
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Medchemexpress LLC IKK 16 | 873225-46-8 | 99.9% | 483.63 | 200 MG
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IKK 16 is an orally active IKK inhibitor that targets IKK2, IKK complex, IKK1, and LRRK2. It also acts as a pan-PKD inhibitor and an ABCB1 inhibitor. IKK 16 provides protection against LPS-induced multiple organ dysfunction, aids in restoring renal function and reducing fibrosis in acute kidney injury, and lessens cardiac dysfunction linked to polymicrobial sepsis in type 2 diabetes mellitus models by inhibiting the NF-κB pathway.
- Orally active IKK inhibitor
- Targets IKK2, IKK complex, IKK1, and LRRK2
- Pan-PKD and ABCB1 inhibitor
- Protects against LPS-induced multiple organ dysfunction
- Restores renal function and reduces fibrosis in acute kidney injury
- Lessens cardiac dysfunction in polymicrobial sepsis in T2DM models
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TARGETMOL CHEMICALS INC VU0155069 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50 46 nM in vitro). purity: 98%
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