Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,151 – 3,165 of 3,769 results

3,151

Ambeed Ni dtbbpy H2O 4 Cl2

[Ni(dtbbpy)(H2O)4]Cl2, 2035424-75-8, 98%

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3,152

Ambeed 5Amino2methoxypyrimidine

5-Amino-2-methoxypyrimidine, 56621-89-7, 98%

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3,153

Ambeed 6Cyclopropylpyridin3amine

6-Cyclopropylpyridin-3-amine, 1159821-66-5, 95%

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3,154

Apexbio Technology LLC ML385(Synonyms: ML-385, NRF2 inhibitor ML385, ML385 NRF2 inhibitor, ML385 inhibitor, NRF2-IN-1, NRF2-IN1), 200mg, CAS: 846557-71-9.

ML385 (CAS 846557-71-9) is a selective inhibitor of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) displaying an IC50 of 1 9 M NRF2 regulates cellular antioxidant responses detoxification pathways and multidrug transporters and its activation is frequently implicated in therapeutic resistance of non-small cell lung cancer (NSCLC) In A549 cells ML385 treatment reduces expression of NRF2-dependent genes dose- and time-dependently Additionally in NSCLC mouse models ML385 treatment diminished tumor growth and metastasis especially when combined with carboplatin underscoring its utility in cancer research and potential therapeutic exploration

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3,155

Apexbio Technology LLC Q-VD(OMe)-OPh 10mg

Q-VD(OMe)-OPh is a pan-caspase inhibitor structurally identified as quinolyl-valyl-O-methylaspartyl-[2 6-difluorophenoxy]-methyl ketone As a broad-spectrum inhibitor Q-VD(OMe)-OPh reversibly targets multiple caspases involved in apoptotic signaling including initiator caspases (such as caspases 8 9 10 and 12) and executioner caspases (such as caspase 3) thereby blocking intrinsic extrinsic and endoplasmic reticulum-mediated apoptotic pathways In recombinant enzyme assays this inhibitor displays nanomolar-range IC values against caspases 1 3 8 and 9 Due to minimal cytotoxicity at tested concentrations Q-VD(OMe)-OPh serves as a tool compound in apoptosis-related biomedical research applied broadly for dissecting caspase-dependent apoptotic mechanisms and evaluating cytoprotective strategies

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3,156

Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG

L-Azidonorleucine hydrochloride is an unnatural amino acid that serves as a methionine surrogate. It is used to label mammalian cell proteins and identify various methionyl-tRNA synthetase (MetRS) mutants. This compound functions as a click chemistry reagent due to its azide group, which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Unnatural amino acid and methionine surrogate
Labels mammalian cell proteins
Identifies methionyl-tRNA synthetase (MetRS) mutants
Functions as a click chemistry reagent
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions

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3,157

Medchemexpress LLC Ethyl indole-2-carboxylate | 3770-50-1 | 99.7% | 189.21 | 50 G

2-Carbethoxyindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.
An indole derivative.
Inhibits benzodiazepine receptor with IC50= 2.2 mM.

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3,158

Medchemexpress LLC Selenocystamine dih 25g

Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles[1][2][3]

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3,159

Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | ≥97.0% | C22H46N4O10 | 250 MG

Azido-PEG10-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PEG-based PROTAC linker for PROTAC synthesis
Functions as a click chemistry reagent
Contains an azide group
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
Supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
PROTACs degrade target proteins via the ubiquitin-proteasome system
Appearance is colorless to off-white

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3,160

Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 G

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine nucleoside analog with a 2'-O-methyl ribose modification, used as an intermediate in the chemical synthesis of modified oligonucleotides and nucleoside derivatives. Molecular formula C31H32N2O8; molecular weight 560.59 g/mol. Follow supplier storage recommendations for long-term stability.

DMT-protected at the 5'-position for controlled deprotection.
2'-O-methyl modification enhances nuclease resistance.
Designed for incorporation into synthetic oligonucleotides.
High purity (98.0%) suitable for research applications.
Stable as a powder under recommended storage conditions.

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3,161

Ambeed 2 4DibromoN 4bromophenyl N 2 4

2,4-Dibromo-N-(4-bromophenyl)-N-(2,4-dibromophenyl)aniline, 73087-81-7, 95%

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3,162

Ambeed Benzyl 3oxocyclobutyl carbama

Benzyl (3-oxocyclobutyl)carbamate, 130369-36-7, 97%

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3,163

Ambeed 3 2 9HFluoren9yl methoxy ca

3-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethoxy)propanoic acid, 1654740-73-4, 97%

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3,164

Apexbio Technology LLC GSK1070916 942918-07-2 200mg

GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

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3,165

Apexbio Technology LLC AS 602801 848344-36-5 200mg

AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions

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Quinolines and derivatives

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Apexbio Technology LLC ML385(Synonyms: ML-385, NRF2 inhibitor ML385, ML385 NRF2 inhibitor, ML385 inhibitor, NRF2-IN-1, NRF2-IN1), 200mg, CAS: 846557-71-9. Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Q-VD(OMe)-OPh 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl indole-2-carboxylate | 3770-50-1 | 99.7% | 189.21 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Selenocystamine dih 25g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | ≥97.0% | C22H46N4O10 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC GSK1070916 942918-07-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC AS 602801 848344-36-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More