Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,661 – 3,675 of 4,595 results

3,661

Medchemexpress LLC Methyl 3,3-dimethoxypropionate | 7424-91-1 | MFCD00010650 | ≥98.0% | 148.16 g/mol | C6H12O4 | 1,000 G

Methyl 3,3-dimethoxypropionate is a small organic ester used as a biochemical reagent and synthetic building block. It functions as a protected methyl ester derivative of 3-hydroxypropionic acid, suitable for use in organic synthesis and life-science research, and is supplied at high purity for laboratory applications.

High purity suitable for research applications.
Molecular weight 148.16 g/mol and formula C6H12O4.
Useful as a protected ester intermediate in synthetic chemistry.
Available in multiple packaging sizes for lab-scale use.
Supplied for research use in laboratory environments.

Pricing & Availability

3,662

Medchemexpress LLC 2-quinolinecarboxaldehyde, 8-hydroxy- | 14510-06-6 | MFCD00168962 | 98.0% | 173.17 g/mol | C10H7NO2 | 1 G

8-Hydroxyquinoline-2-carbaldehyde is an organic biochemical reagent (C10H7NO2, MW 173.17 g/mol) used as a building block in organic synthesis and as a ligand in coordination and analytical chemistry. It is supplied as a solid powder in laboratory pack sizes for research applications, with batch-specific certificates of analysis available for quality confirmation.

Acts as a building block for organic synthesis.
Functions as a bidentate ligand and chelating agent.
Suitable for analytical and proteomics applications.
Provided in small pack sizes appropriate for laboratory research.
Batch-specific certificate of analysis available for purity verification.

Pricing & Availability

3,663

Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 | C31H32N2O8 | 5 G

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine analog used as a nucleoside building block and intermediate for the synthesis of modified oligonucleotides. It is supplied as a light-yellow solid with defined purity and storage specifications suited for research and preparative oligonucleotide chemistry.

DMT protected at the 5' hydroxyl for selective chain assembly.
2'-O-methyl modification supports increased nuclease resistance in oligonucleotides.
High purity material suitable for synthesis and analytical workflows.
Available in gram-scale pack sizes to accommodate different synthesis scales.
Stable under recommended storage conditions to preserve quality over time.

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3,664

Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG

Romaciclib monohydrochloride (SEL120-34A monohydrochloride) is an ATP-competitive and selective inhibitor of Cyclin-Dependent Kinase 8 (CDK8). It demonstrates potent inhibitory activity against the kinase complexes of CDK8/CycC and CDK19/CycC, with IC50 values of 4.4 nM and 10.4 nM, respectively, and a Kd of 3 nM for CDK8. While it weakly inhibits CDK9, it shows no significant activity against other CDKs such as CDK1, 2, 4, 6, 5, and 7. The compound effectively inhibits the phosphorylation of STAT1 S727 and STAT5 S726 and has demonstrated anti-tumor activity.

Selective inhibition of specific cyclin-dependent kinases.
ATP-competitive mechanism of action.
Impacts key signaling pathways by inhibiting STAT1 S727 and STAT5 S726 phosphorylation.
Demonstrated efficacy in anti-tumor applications.

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3,665

Medchemexpress LLC mPEG-amine (MW 10000) | 80506-64-5 | 637448 | 98.0% | (C2H4O)nC3H9NO | 100 MG

mPEG-amine (MW 10000), also known as mPEG-NH2 (MW 10000), is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase and the other targets a specific protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Enables selective protein degradation
Average molecular weight of 10000
Appears as a white to off-white solid

Pricing & Availability

3,666

Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 1 G

Benzyl-PEG5-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It has a molecular weight of 327.42, appears as a liquid, and is colorless to light yellow.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
Molecular weight of 327.42
Liquid appearance
Colorless to light yellow
Purity of 98.0%

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3,667

Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 50 MG

Lobeglitazone sulfate is a new type of thiazolidinedione and an orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. It is an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway and exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.

Orally active agonist for PPAR.
Inhibits the ERK/JNK/Smad/NF-κB signaling pathway.
Exhibits anti-inflammatory properties.
Possesses anti-diabetic properties.
Demonstrates anti-fibrotic and anti-atherosclerotic properties.

Pricing & Availability

3,668

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 100 MG

5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis.

Purine nucleoside analog
Exhibits broad antitumor activity
Targets indolent lymphoid malignancies
Inhibits DNA synthesis
Induces apoptosis

Pricing & Availability

3,669

Medchemexpress LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG

HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.

Potent antimicrobial agent with LTA biosynthesis inhibition.
Inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL.
Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
Inhibits pro-inflammatory cytokines.
Directly binds to PgsA.
Downregulates the expression level of PgsA, an essential protein for phospholipid synthesis.

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3,670

Medchemexpress LLC Letrozole (Standard) | 112809-51-5 | C17H11N5 | 200 MG

Letrozole (CGS 20267) is a potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. It selectively inhibits estrogen biosynthesis and can be used for breast cancer research.

Potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase
Selectively inhibits estrogen biosynthesis
Used for breast cancer research
Exhibits anti-tumor effects in rats
Inhibits growth of MCF-7 epithelial breast cancer cells

Pricing & Availability

3,671

Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g/mol | C14H16N2O9S | 500MG

Disuccinimidyl sulfoxide (DSSO) is a homobifunctional, amine-reactive, sulfoxide-containing cross-linker developed for cross-linking mass spectrometry workflows. It incorporates two symmetric CID-cleavable sites that produce characteristic fragmentation patterns, enabling confident identification of cross-linked peptides and aiding structural proteomics and protein interaction mapping.

MS-cleavable sulfoxide core for characteristic CID fragmentation.
Homobifunctional, N-hydroxysuccinimide ester reactivity toward primary amines.
Enables confident identification of cross-linked peptides in proteomics studies.
High purity (≈99.8%) white to off-white solid.
Suitable for cross-linking model peptides, proteins, and multisubunit complexes.

Pricing & Availability

3,672

Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML

LM11A-31 dihydrochloride is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and an orally active, potent antagonist of proNGF (nerve growth factor). This amino acid derivative demonstrates high blood-brain barrier permeability, effectively blocking p75-mediated cell death. It has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease at mid- to late-stage progression.

Non-peptide p75NTR modulator
Orally active and potent proNGF antagonist
Amino acid derivative
High blood-brain barrier permeability
Blocks p75-mediated cell death
Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models

Pricing & Availability

3,673

Medchemexpress LLC Quin C1 | 786706-21-6 | 98.5% | 445.51 | 500 UG

Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). It significantly reduces neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue.

Highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX)
Significantly reduces neutrophil and lymphocyte counts in BALF
Diminishes expression of TNF-α, IL-1β, KC, and TGF-β1
Decreases collagen deposition in lung tissue
Potential for research into lung injury

Pricing & Availability

3,674

Medchemexpress LLC Capivasertib | 1143532-39-1 | C21H25ClN6O2 | 200 MG

Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor, effectively inhibiting Akt1, Akt2, and Akt3 with high selectivity. This compound demonstrates in vitro inhibition of cancer cell proliferation, leading to apoptosis and G1 cell cycle arrest. In vivo studies confirm its good oral bioavailability, favorable pharmacokinetic properties, and significant ability to inhibit tumor growth in various human xenograft models. It is currently undergoing clinical evaluation.

Potent pan-AKT kinase inhibitor
Highly selective for Akt over other kinases
Inhibits proliferation in diverse cancer cell lines
Induces apoptosis and G1 cell cycle arrest
Exhibits good oral bioavailability
Effectively inhibits tumor growth in xenograft models
Inhibits P70S6K, PKA, and ROCK2 activity
Suppresses phosphorylation of AKT substrates
Induces FOXO3a nuclear translocation

Pricing & Availability

3,675

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 50 MG

5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine is a purine nucleoside analog. This chemical compound is known for its broad antitumor activity, particularly targeting indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and induction of apoptosis, making it a subject of interest in cancer research.

Purine nucleoside analog
Exhibits broad antitumor activity
Targets indolent lymphoid malignancies
Inhibits DNA synthesis
Induces apoptosis

Pricing & Availability

Quinolines and derivatives

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Medchemexpress LLC Methyl 3,3-dimethoxypropionate | 7424-91-1 | MFCD00010650 | ≥98.0% | 148.16 g/mol | C6H12O4 | 1,000 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-quinolinecarboxaldehyde, 8-hydroxy- | 14510-06-6 | MFCD00168962 | 98.0% | 173.17 g/mol | C10H7NO2 | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 | C31H32N2O8 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC mPEG-amine (MW 10000) | 80506-64-5 | 637448 | 98.0% | (C2H4O)nC3H9NO | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Letrozole (Standard) | 112809-51-5 | C17H11N5 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Disuccinimidyl sulfoxide | 1351828-03-9 | MFCD30497419 | 99.8% | 388.35 g/mol | C14H16N2O9S | 500MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Quin C1 | 786706-21-6 | 98.5% | 445.51 | 500 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Capivasertib | 1143532-39-1 | C21H25ClN6O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine | 2095417-73-3 | C31H32N2O9 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More