Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | 99.9% | 564.65 g/mol | C29H32N4O6S | 50 MG
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Ruboxistaurin mesylate is an orally active, selective, ATP-competitive protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal disorders, and cardiovascular conditions. Supplied as the mesylate salt, it is an orange-to-red solid with molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.
- Selective PKCβ inhibition with low nanomolar potency (IC50 ~4.7-5.9 nM).
- Mesylate salt form for improved stability and handling.
- High purity (99.87%) suitable for research applications.
- Orange-to-red solid, convenient for solid-state storage.
- Molecular formula C29H32N4O6S and molecular weight 564.65 g/mol.
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Medchemexpress LLC Tirapazamine | 27314-97-2 | 99.0% | 178.15 | 200 MG
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Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single- and double-strand breaks in DNA, base damage, and cell death. It is an anticancer and bioreductive agent that can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.
- Selective cytotoxicity for hypoxic cells
- Induces single- and double-strand breaks in DNA
- Induces base damage and cell death
- Enhances cytotoxic effects of ionizing radiation in hypoxic cells
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Medchemexpress LLC Act-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG
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Act-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG
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Medchemexpress LLC PI3K-IN-31 10mM | 10MM/1ML
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PI3K-IN-31 10mM | 10MM/1ML
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Medchemexpress LLC Mpeg-amine (mw 5000) | 80506-64-5 | 99.6% | (C2H4O)nC3H9NO | 100 MG
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mPEG-amine (mPEG-NH2) (MW 5000) is a modifier used to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes by replacing their sulfonic acid portion. It can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS.
- Increases water solubility of dyes
- Forms amide bonds with carboxyl groups
- Suitable for large-scale rotational cytoplasmic flow studies
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Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | MFCD09970504 | 99.9% | 564.65 | C29H32N4O6S | 5 MG
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Ruboxistaurin mesylate is an orally active, ATP-competitive, and selective protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal/eye disorders, and cardiovascular disease. It is supplied as a solid with high reported purity and is soluble in DMSO for in vitro applications.
- Selective PKCβ inhibitor with low-nanomolar potency.
- Orally active small molecule suitable for in vitro and in vivo studies.
- High reported purity (~99.9%) for research applications.
- Solid form, orange to red color, easy handling and storage.
- Soluble in DMSO at 50 MG/ML (88.55 mM); ultrasonic assistance may be required.
- Storage guidance: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
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Medchemexpress LLC Dd-03-171 | 2366132-45-6 | 98.7% | 25MG
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Dd-03-171 | 2366132-45-6 | 98.7% | 25MG
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Medchemexpress LLC 2-quinolinecarboxaldehyde, 8-hydroxy- | 14510-06-6 | MFCD00168962 | 98.0% | 173.17 g/mol | C10H7NO2 | 1 G
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8-Hydroxyquinoline-2-carbaldehyde is an organic biochemical reagent (C10H7NO2, MW 173.17 g/mol) used as a building block in organic synthesis and as a ligand in coordination and analytical chemistry. It is supplied as a solid powder in laboratory pack sizes for research applications, with batch-specific certificates of analysis available for quality confirmation.
- Acts as a building block for organic synthesis.
- Functions as a bidentate ligand and chelating agent.
- Suitable for analytical and proteomics applications.
- Provided in small pack sizes appropriate for laboratory research.
- Batch-specific certificate of analysis available for purity verification.
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Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG
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Romaciclib monohydrochloride (SEL120-34A monohydrochloride) is an ATP-competitive and selective inhibitor of Cyclin-Dependent Kinase 8 (CDK8). It demonstrates potent inhibitory activity against the kinase complexes of CDK8/CycC and CDK19/CycC, with IC50 values of 4.4 nM and 10.4 nM, respectively, and a Kd of 3 nM for CDK8. While it weakly inhibits CDK9, it shows no significant activity against other CDKs such as CDK1, 2, 4, 6, 5, and 7. The compound effectively inhibits the phosphorylation of STAT1 S727 and STAT5 S726 and has demonstrated anti-tumor activity.
- Selective inhibition of specific cyclin-dependent kinases.
- ATP-competitive mechanism of action.
- Impacts key signaling pathways by inhibiting STAT1 S727 and STAT5 S726 phosphorylation.
- Demonstrated efficacy in anti-tumor applications.
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Medchemexpress LLC Sulfo-Cy3 amine | 2183440-43-7 | 99.7% | 714.93 g/mol | C36H50N4O7S2 | 10 MG
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Sulfo-Cy3 amine is a water-soluble Cyanine3 derivative containing a primary amine for covalent conjugation to biomolecules. The sulfonate groups increase aqueous solubility and the dye provides bright, photostable fluorescence for imaging and detection applications. Soluble in DMSO; may require ultrasonication and dry DMSO for best results.
- Water-soluble sulfonated Cy3 derivative suitable for aqueous labeling.
- Primary amine functional group for conjugation to electrophiles and carboxyl groups.
- High purity for consistent labeling performance.
- Soluble in DMSO (125 mg/mL); may require ultrasonication and newly opened DMSO.
- Bright, photostable fluorescence for imaging and detection applications.
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Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 | C31H32N2O8 | 5 G
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5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine analog used as a nucleoside building block and intermediate for the synthesis of modified oligonucleotides. It is supplied as a light-yellow solid with defined purity and storage specifications suited for research and preparative oligonucleotide chemistry.
- DMT protected at the 5' hydroxyl for selective chain assembly.
- 2'-O-methyl modification supports increased nuclease resistance in oligonucleotides.
- High purity material suitable for synthesis and analytical workflows.
- Available in gram-scale pack sizes to accommodate different synthesis scales.
- Stable under recommended storage conditions to preserve quality over time.
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Medchemexpress LLC SARS-CoV-2-IN-86 | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 G
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SARS-CoV-2-IN-86 is a small-molecule research compound that inhibits SARS-CoV-2 methyltransferases (nsp14 and nsp16) and is reported as an andrographolide derivative. It is supplied as a solid or as a 10 mM solution in DMSO for in vitro antiviral and enzymatic studies. Batch-specific certificates of analysis and safety documentation are available from the supplier.
- Inhibits SARS-CoV-2 methyltransferases (nsp14 and nsp16).
- Andrographolide derivative for antiviral research.
- Available as solid and 10 mM solution in DMSO.
- High purity (≈99.4%) per supplier documentation.
- Suitable for in vitro enzymatic and antiviral assays.
- Powder stable at -20°C; solvent storage guidelines available.
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Medchemexpress LLC SRI 6409-94 | 127697-58-9 | 99.25% | 379.49 | 5 MG
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SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
- Orally active compound.
- Aids in the study of retinol's three-dimensional configuration and its effect on teratogenic activity.
- Induces deformed offspring in a dose-dependent manner in virgin female outbred Syrian golden hamsters.
- Leads to significant reductions in mean fetal body weight and the number of ossified skeletal districts in studies.
- Purity of 99.25%.
- Available in solid form with a light yellow to brown color.
- Stable for 3 years at -20°C as a powder, and 2 years at 4°C as a powder.
- In solvent, stable for 6 months at -80°C and 1 month at -20°C.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379313 VINPOCETINE 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379286 ICG-AMINE 1MG
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