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Filtered Search Results
Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 | C11H12N2O7 | 10 MG
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Mal-amido-(CH2COOH)2 is a maleimidoethyl-containing intermediate used in the synthesis of hydrophilic antibody-drug conjugate (ADC) linkers. It is a small-molecule building block supplied for research use only.
- Contains maleimidoethyl functionality for conjugation reactions.
- Suitable for hydrophilic ADC linker synthesis.
- High reported purity (99.15%).
- Molecular formula C11H12N2O7 and molecular weight 284.22.
- Available in small mg-scale quantities for research applications.
- For research use only; not for human or clinical use.
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Medchemexpress LLC Azido-PEG9-amine | 1207714-69-9 | 98.5% | 482.57 g/mol | C20H42N4O9 | 50 MG
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Azido-PEG9-amine is a non-cleavable nine-unit polyethylene glycol (PEG) linker bearing an azide and a terminal amine. It is used for antibody-drug conjugate and PROTAC synthesis and enables bioconjugation via click chemistry (CuAAC and SPAAC).
- Molecular formula: C20H42N4O9.
- Molecular weight: 482.57 g/mol.
- Cas number: 1207714-69-9.
- Purity: 98.52%.
- Available package sizes: 50 mg, 100 mg, 250 mg, 500 mg, 1 g.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition for bioconjugation.
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Medchemexpress LLC Bapta | 85233-19-8 | MFCD00036255 | 98.1% | 476.43 g/mol | C22H24N2O10 | 200 MG
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Bapta is a selective calcium (Ca2+) chelator used in biochemical and cellular research to buffer intracellular calcium and probe calcium-dependent signaling. It exhibits high selectivity over magnesium and can act as a calcium indicator; it has also been reported to inhibit phospholipase C independent of its chelating activity.
- Selective chelation of calcium with high magnesium selectivity.
- Functions as an intracellular calcium buffer and indicator.
- Useful for studying calcium-dependent signaling and calcium influx.
- Can inhibit phospholipase C independent of calcium chelation.
- Available in solid form and as ready-to-use solution formulations.
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Apexbio Technology LLC N-Methylnicotinamide 114-33-0 200mg
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N-Methylnicotinamide (CAS 114-33-0) is a methylated derivative of nicotinamide and a primary metabolic product of niacinamide and niacin (vitamin B3) catabolism It does not have a defined therapeutic target or approved clinical use but plays a significant role in biomedical research as an indicator of vitamin B3 status Measurement of urinary N-methylnicotinamide is routinely employed to assess niacin sufficiency and diagnose deficiencies reflecting metabolic function related to NAD/NADP biosynthesis pathways This compound thus serves as a valuable biomarker in nutritional and metabolic research contexts
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Apexbio Technology LLC Azelastine HCl 79307-93-0 200mg
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Azelastine HCl (79307-93-0) is a small-molecule antagonist targeting the histamine H1 receptor It is designed to inhibit the H1 receptor thereby disrupting histamine-induced inflammatory and allergic pathway signaling Azelastine HCl exerts its biological activity primarily through competitive antagonism of H1 receptors blocking downstream cascades including smooth muscle contraction increased endothelial permeability and inflammatory mediator release In receptor-binding studies Azelastine HCl demonstrates antagonist activity with IC50 values of approximately 1 2 2 5 nM Based on these pharmacological properties Azelastine HCl holds research potential in the investigation of allergy pathogenesis allergic inflammation mechanisms and the evaluation of receptor-specific responses in cellular and animal models
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Medchemexpress LLC Mal-amido-(CH2COOH)2 | 207613-14-7 | 99.2% | 284.22 g·mol-1 | C11H12N2O7 | 50 MG
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Mal-amido-(CH2COOH)2 is a maleimidoethyl-containing intermediate used in the synthesis of hydrophilic antibody-drug conjugate (ADC) linkers for research applications. It is supplied as a solid with high purity and is formulated to dissolve in DMSO for downstream conjugation workflows.
- CAS number 207613-14-7.
- Purity 99.2%.
- Molecular formula C11H12N2O7.
- Molecular weight 284.22 g·mol-1.
- Appearance solid; soluble in DMSO with ultrasonic warming and heating to 60°C.
- Storage powder -20°C up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Intended for research use only; not for human use.
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Medchemexpress LLC Pyrroloquinoline quinone disodium salt | 122628-50-6 | 98.0% | 374.17 g/mol | C14H4N2Na2O8 | 25 MG
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Pyrroloquinoline quinone disodium salt is a redox cofactor used in biochemical and cell biology research. Supplied as the disodium salt with high purity, it is intended for studies of enzymatic activity, mitochondrial function, and oxidative stress.
- High purity (98.0%) for research-grade experiments.
- Redox cofactor useful in enzymology and metabolic studies.
- Suitable for cellular assays examining mitochondrial function and oxidative stress.
- Disodium salt form improves aqueous solubility compared with the free acid.
- Provided in small milligram pack sizes suitable for preliminary and in vitro work.
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![eMolecules 957486-82-7 | Azido-PEG6-amine | ChemScene | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 5g | 801487994](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215942.jpg-250.jpg)
eMolecules 957486-82-7 | Azido-PEG6-amine | ChemScene | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 5g | 801487994
Azido-PEG6-amine | ChemScene | 957486-82-7 | MFCD03453240 | 350.416 | C14H30N4O6 | 97.000 | NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 5g | 801487994
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Apexbio Technology LLC LDK378 1032900-25-6 200mg
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LDK378 (CAS 1032900-25-6) is a potent inhibitor of anaplastic lymphoma kinase (ALK) a receptor tyrosine kinase within the insulin receptor superfamily It exhibits an in vitro IC50 of 200 pM for ALK and displays moderate to high inhibitory activity against a limited set of other kinases including IGF-1R (IC50 8 nM) InsR (IC50 7 nM) and STK22D (IC50 23 nM) LDK378 suppresses proliferation of Ba/F3 cells transfected with NPM-ALK fusion and Karpas 299 human lymphoma cells harboring NPM-ALK with IC50 values of 22 8 nM and 26 nM respectively The compound is widely used in preclinical studies to investigate ALK-driven signaling and its potential as a therapeutic target in oncology
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![eMolecules 92921-24-9 | Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt | Chem-Impex | MFCD00054978 | 436.370 | C16H17N2NaO9S | 96.000 | [Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)C1=O | 100mg | 272386940](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000129239.jpg-250.jpg)
eMolecules 92921-24-9 | Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt | Chem-Impex | MFCD00054978 | 436.370 | C16H17N2NaO9S | 96.000 | [Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)C1=O | 100mg | 272386940
Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt | Chem-Impex | 92921-24-9 | MFCD00054978 | 436.370 | C16H17N2NaO9S | 96.000 | [Na+].[O-]S(=O)(=O)C1CC(=O)N(OC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)C1=O | 100mg | 272386940
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Apexbio Technology LLC IAA-94 54197-31-8 25mg
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IAA-94 (CAS 54197-31-8) is a small-molecule inhibitor of epithelial chloride channels modulating cellular electrophysiological properties by disrupting chloride ion transport Experimental studies have demonstrated that IAA-94 can interfere with interactions involving the negative factor (Nef) protein during infection indicating its capacity to modulate Nef-mediated processes Due to its specificity in targeting chloride channels IAA-94 is widely utilized in investigations of ion channel-related signaling pathways in tumor cells and serves as a valuable tool in studies of cell electrophysiology and infection mechanisms
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Apexbio Technology LLC Proflavine Hemisulfate 1811-28-5 10mM (in 1mL DMSO)
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Proflavine Hemisulfate (CAS 1811-28-5) is a small-molecule inhibitor targeting DNA It is designed to intercalate into DNA strands thereby disrupting DNA replication and transcription Proflavine Hemisulfate exerts its biological activity primarily through DNA intercalation In in vitro studies Proflavine Hemisulfate demonstrates antimicrobial activity with reported IC50 values for inhibiting bacterial growth typically ranging between 1 10 M depending on the microbial strain and assay conditions used Based on these pharmacological properties Proflavine Hemisulfate holds research potential in studies of antimicrobial activity DNA replication assays mutagenesis and evaluating sensitivity and resistance profiles of microorganisms
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Apexbio Technology LLC Penicillin V potassium salt 132-98-9 200mg
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Penicillin V potassium salt (132-98-9) is a small-molecule inhibitor targeting bacterial cell wall peptidoglycan synthesis It is designed to inhibit this biosynthetic pathway thereby suppressing the growth of Gram-positive bacteria Penicillin V potassium salt exerts its biological activity primarily through inhibition of bacterial cell wall synthesis In microbial susceptibility assays Penicillin V potassium salt demonstrates inhibitory effects with IC50 values ranging from approximately 0 01 to 0 5 g/mL for sensitive bacterial strains Based on these pharmacological properties Penicillin V potassium salt holds research potential in studies investigating Gram-positive bacterial resistance mechanisms cell-wall targeting antibiotic actions and experimental models of upper respiratory tract infections including otitis media sinusitis pharyngitis and tonsillitis
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Apexbio Technology LLC Dabigatran etexilate mesylate 872728-81-9 10mg
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Dabigatran etexilate mesylate (CAS 872728-81-9) is an orally administered prodrug that upon conversion to dabigatran functions as a selective and reversible direct thrombin inhibitor In biochemical assays dabigatran exhibits high affinity for human thrombin (Ki 4 5 nM) and inhibits thrombin-induced platelet aggregation (IC50 10 nM) without affecting other platelet activators In vitro it induces concentration-dependent prolongation of coagulation parameters including aPTT PT and ECT in human plasma In vivo studies in rats and rhesus monkeys demonstrate dose-dependent anticoagulant activity following both intravenous and oral administration Dabigatran etexilate is utilized in research focused on coagulation disorders and anticoagulant mechanisms
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Apexbio Technology LLC 17-Hydroxyprogesterone 68-96-2 200mg
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17-Hydroxyprogesterone (68-96-2) is a small-molecule agonist targeting the progesterone receptor (PR) with partial agonist activity at glucocorticoid receptors (GR) and antagonist effects at mineralocorticoid receptors (MR) It modulates steroid hormone signaling pathways thereby influencing vascular tone and inflammation 17-Hydroxyprogesterone exerts its biological activity primarily through activation and modulation of steroid hormone receptors In animal models administration of 17-Hydroxyprogesterone demonstrates the ability to modulate vascular inflammation and uterine vascular tone Based on these pharmacological properties 17-Hydroxyprogesterone holds research potential in the screening of congenital adrenal hyperplasia and related metabolic syndromes as well as associations with respiratory distress syndrome and premature birth outcomes
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