Quinolines and derivatives
Medchemexpress LLC 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid | 846549-37-9 | 98.6% | C22H42N4O12 | 250 MG
This PEG-based PROTAC linker, 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid, is designed for the synthesis of PROTACs. It functions as a click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, or strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. It is intended for research use only.
- Utilizes PEG-based PROTAC linker technology
- Features an azide group for click chemistry reactions
- Supports copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Suitable for PROTAC synthesis
Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | 99.9% | C22H33N3O6 | 1 ML
Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat. It reduces plasma ACE activity and can be used in the research of hypertension (including essential and renal hypertension) and congestive heart failure. This product is for research use only and not sold to patients.
- Orally active prodrug
- Reduces plasma ACE activity
- Used in research of hypertension
- Used in research of congestive heart failure
- Evokes significant plasma ACE inhibition
- Reduces blood pressure in dogs with renal hypertension
- Improves postischemic myocardial function in hyperthyroid rats
Apexbio Technology LLC SCH772984 TFA 942183-80-4 (free base) 200mg
SCH772984 TFA is a small-molecule inhibitor targeting extracellular signal-regulated kinase 1/2 (ERK1/2) It is designed to inhibit ERK catalytic activity thereby blocking phosphorylation of downstream substrates and regulating the RAS-RAF-MEK-ERK signaling pathway SCH772984 TFA exerts its biological activity primarily through direct interaction with ERK1/2 acting as an ATP-competitive inhibitor Based on these pharmacological properties SCH772984 TFA holds research potential in studies examining ERK signaling s role in oncogenic pathway activation tumor cell growth survival mechanisms and resistance phenomena in various cancer models
TARGETMOL CHEMICALS INC MORACIN C 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Moracin C a natural compound found in Morus mesozygia Morus alba var. multicaulis is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells. purity: 99%
Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 200mg
Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival
Apexbio Technology LLC Tasquinimod 254964-60-8 200mg
Tasquinimod (CAS 254964-60-8) is an orally bioavailable quinoline-3-carboxamide compound with antiangiogenic and antitumor properties It modulates angiogenesis primarily through dual inhibition of S100A9/TLR4 signaling in myeloid-derived suppressor cells (MDSCs) and downregulation of HIF-1 and VEGF expression in tumor and endothelial cells It also enhances thrombospondin-1 (TSP-1) expression further suppressing neovascularization Preclinical studies in human prostate cancer xenograft models indicate significant antineoplastic activity particularly in combination with docetaxel radiation therapy or androgen-depletion strategies suggesting its therapeutic potential for castration-resistant prostate cancer (CRPC)
Medchemexpress LLC Paliperidone (9-Hydroxyrisperidone) | 144598-75-4 | 99.4% | C23H27FN4O3 | 200 MG
Paliperidone (9-Hydroxyrisperidone) is the major active metabolite of Risperidone, functioning as a dopamine D2 and 5-HT2A antagonist. It also exhibits antagonist activity at α1 and α2 adrenergic receptors and H1-histaminergic receptors, demonstrating efficacy as an antipsychotic agent against schizophrenia.
- Major active metabolite of risperidone
- Dopamine D2 antagonist
- 5-HT2A antagonist
- Antagonist at α1 and α2 adrenergic receptors
- Antagonist at H1-histaminergic receptors
- Effective antipsychotic agent against schizophrenia
- For research use only
- Increases caspase-3 activity in neuroblastoma cells
- May modulate Akt1/GSK3β pathway to protect SK-N-SH cells from glutamate damage
- Can protect SK-N-SH cells from apoptosis induced by glutamate
TARGETMOL CHEMICALS INC Rivastigmine 200MG
Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease. Purity 99.85%
Medchemexpress LLC AS1842856 | 836620-48-5 | MFCD30718173 | 99.9% | 347.38 g/mol | C18H22FN3O3 | 200 MG
AS1842856 is a small-molecule Foxo1 inhibitor used in laboratory research to probe FOXO1-regulated pathways, including autophagy. The compound (CAS 836620-48-5) is cell-permeable, reported to have potent inhibitory activity (IC50 ≈ 30 nM), and is supplied with supporting analytical documentation for research use.
- Potent Foxo1 inhibitor activity (IC50 ≈ 30 nM).
- High reported purity suitable for analytical and biological experiments.
- Available as solid and as a DMSO solution for flexible formulation.
- Defined storage stability for powder and for solutions under controlled conditions.
- Includes datasheet, certificate of analysis, and safety data sheet for traceability and safe handling.
- Appropriate for in vitro studies of autophagy and FOXO1 signaling pathways.
Apexbio Technology LLC Tetracycline(Synonyms: Achromycin, Sumycin, Tetracyn, Tetrex, Panmycin, Robitet, Polycycline, Cyclopar), 200mg, CAS: 60-54-8.
Tetracycline (CAS 60-54-8) is a broad-spectrum polyketide antibiotic originally isolated from Streptomyces species It functions primarily through reversible binding to the bacterial 30S ribosomal subunit disrupting the interaction of aminoacyl-tRNA with the ribosomal acceptor site and thereby inhibiting bacterial protein synthesis Additionally tetracycline interacts partially with the 50S ribosomal subunit and may compromise bacterial membrane integrity causing leakage of intracellular components Tetracycline remains widely employed in microbiological research as an antibiotic selection marker and a tool for investigating ribosomal functions
Medchemexpress LLC Sulfo-EGS 25mg | 167410-92-6 | 616.48 | C18H20N2O18S2 | 25 MG
Sulfo-EGS is a water-soluble, homobifunctional, amine-reactive crosslinker used to probe protein-protein and protein-peptide interactions by forming stable covalent links between proximal lysine residues. It is soluble in water and DMSO and supplied for research use.
- Water-soluble homobifunctional amine-reactive crosslinker.
- Enables covalent crosslinking of proximal lysine residues to map interactions.
- Soluble in water and DMSO for flexible experimental conditions.
- Typical purity of 90.0% suitable for research applications.
- Available in small pack sizes for bench-scale experiments.
Medchemexpress LLC Bosutinib hydrate | 918639-08-4 | MFCD29920031 | 100.0% | 548.46 g/mol | C26H31Cl2N5O4 | 200 MG
Bosutinib hydrate is a small-molecule dual Src/Abl tyrosine kinase inhibitor supplied as a white to off-white solid for research use. It exhibits low-nanomolar potency against Src and Abl kinases and is intended for biochemical and cell-based studies; supporting documents such as SDS and COA are provided for analytical verification and safe handling.
- Dual Src and Abl kinase inhibition at low-nanomolar concentrations.
- High reported purity suitable for research applications.
- Available in multiple packaging sizes, including 200 MG.
- White to off-white solid appearance for easy handling.
- Storage and stability guidance provided for solid and solution forms.
- COA and SDS available to support quality and safety use.
Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.3% | 450.60 | 25 MG
Romaciclib monohydrochloride is an ATP-competitive and selective CDK8 inhibitor. It inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, and has a Kd of 3 nM for CDK8. It weakly inhibits CDK9 but shows no significant activity against CDK1, 2, 4, 6, 5, or 7. This compound inhibits phosphorylation of STAT1 S727 and STAT5 S726, demonstrating anti-tumor activity.
- ATP-competitive and selective CDK8 inhibitor.
- Inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes.
- Weakly inhibits CDK9 and shows no obvious activity against several other CDKs (CDK1, 2, 4, 6, 5, 7).
- Inhibits phosphorylation of STAT1 S727 and STAT5 S726.
- Possesses anti-tumor activity.
- Decreases IRF9 and STAT1 mRNA expression and mitogen-induced IER expression.
- Inhibits growth of AML tumors in a dose-dependent manner in SCID mice.
Apexbio Technology LLC Finasteride 98319-26-7 200mg
Finasteride (CAS 98319-26-7) is a small molecule inhibitor of type II 5 -reductase exhibiting an IC of 65 nM By selectively blocking this enzyme finasteride impedes the conversion of testosterone to dihydrotestosterone (DHT) leading to reduced DHT concentrations in prostatic tissue and a subsequent decrease in prostate size in vivo Due to its oral bioavailability and well-characterized mechanism finasteride is widely utilized in research focused on androgen signaling prostatic diseases and the physiological roles of DHT