Quinolines and derivatives
Medchemexpress LLC Ly294002 | 154447-36-6 | 307.34 | 200 MG
LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ, and PI3Kβ, respectively. It also inhibits CK2 with an IC50 of 98 nM. LY294002 acts as a competitive DNA-PK inhibitor, binding reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM, and is also an apoptosis activator.
- Targets PI3K, Casein Kinase, DNA-PK
- Supports research in apoptosis, autophagy, infection, and cancer
- Has IC50 values for PI3Kα (0.5 μM), PI3Kδ (0.57 μM), PI3Kβ (0.97 μM), CK2 (98 nM), and DNA-PK (1.4 μM)
- Acts as an apoptosis activator
Medchemexpress LLC Sodium dichloroacetate | 2156-56-1 | MFCD00070489 | 99.8% | 150.92 | C2HCl2NaO2 | 200mg
Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na -K -2Cl cotransporter (NKCC) inhibitor Sodium dichloroacetate prevents the phosphorylation of the E1 subunit of PDC promoting the entry of pyruvate into the mitochondria for oxidative metabolism reducing lactate production and simultaneously increasing the production of reactive oxygen species (ROS) Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis Sodium dichloroacetate is promising for research of cancers[1][2]
Medchemexpress LLC SC79 | 305834-79-1 | 98.0% | 364.78 | 200 MG
SC79 is a unique, specific, and BBB permeable Akt activator. It activates Akt in the cytosol and inhibits Akt membrane translocation, specifically binding to the PH domain of Akt. It is for research use only.
- Augments Akt phosphorylation at both Thr308 and S473 sites.
- Reduces neuronal excitotoxicity and prevents stroke-induced neuronal death.
- Suppresses PHAKTM-GFP plasma membrane translocation.
- Protects against fas-induced fulminant hepatic failure.
- Protects hepatocytes from TNFα-mediated apoptosis and from Gal/LPS-induced liver injury and damage.
Apexbio Technology LLC Androgen receptor antagonist 9 915086-32-7 200mg
Androgen receptor antagonist 9 (CAS 915086-32-7) is a small molecule inhibitor that binds to the androgen receptor (AR) thereby preventing androgens such as testosterone and dihydrotestosterone from interacting with the receptor By disrupting AR signaling pathways this compound can suppress the proliferation and growth of tumor cells in androgen-dependent malignancies Androgen receptor antagonist 9 is utilized in research investigating the pathogenesis and treatment of diseases such as prostate cancer where androgen signaling is implicated
Apexbio Technology LLC Pimobendan 74150-27-9 200mg
Pimobendan (CAS 74150-27-9) is a small molecule that acts as a selective phosphodiesterase 3 (PDE3) inhibitor exhibiting an IC50 of 0 32 M By inhibiting PDE3 activity Pimobendan modulates intracellular cyclic nucleotide levels thereby influencing cellular signaling pathways involved in cardiovascular function This compound is utilized in biomedical research to investigate PDE3-mediated mechanisms and their implications in cardiac physiology and related disease models
Apexbio Technology LLC Rimantadine 13392-28-4 200mg
Rimantadine (13392-28-4) is a small-molecule inhibitor targeting the M2 ion channel protein of influenza A virus It is designed to specifically block the M2 channel thereby inhibiting the viral uncoating process and preventing subsequent viral entry into host cells Rimantadine exerts its biological activity primarily through inhibition of the M2 ion channel In in vitro studies rimantadine demonstrates antiviral activity with reported IC50 values typically ranging from approximately 0 1 to 1 M depending on virus strain and experimental context Based on these pharmacological properties rimantadine holds research potential in investigating influenza A viral replication resistance mutations infection pathways and in evaluating antiviral activity and establishing infection models in vitro
Medchemexpress LLC 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid | 846549-37-9 | 98.6% | C22H42N4O12 | 1 G
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Features an Azide group for CuAAc reactions
- Participates in SPAAC reactions
- Relevant to click chemistry and PROTAC synthesis
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-CO-C9-acid (VH032-NH-CO-C9-acid) | 2172819-78-0 | 95.0% | 628.82 | 25 MG
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. This product is for research use only and not validated for medical applications.
- E3 ligase ligand-linker conjugate
- Connects to ligand for protein to form PROTACs
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light and under nitrogen
- In solvent, store at -80°C for 6 months, or -20°C for 1 month, protected from light and under nitrogen
- Soluble in DMSO
- Soluble in various in vivo protocols
Medchemexpress LLC 10-Deacetylbaccatin III | 32981-86-5 | 99.79% | 544.59 | 200 MG
10-Deacetylbaccatin III (Standard) is the analytical standard of 10-Deacetylbaccatin III, intended for research and analytical applications. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Grade of analytical standard.
- Reference standard supplied assay.
- Commonly used in HPLC, GC, and MS research experiments.
Medchemexpress LLC Nilotinib monohydrochloride monohydrate | 923288-90-8 | MFCD18251359 | >98.0% | 583.99 g/mol | C28H25ClF3N7O2 | 200 MG
Nilotinib monohydrochloride monohydrate is the monohydrochloride monohydrate salt of nilotinib, a second-generation Bcr-Abl tyrosine kinase inhibitor used in research to study Bcr-Abl-driven signaling and oncology applications. Provided as a high-purity research compound, it is suitable for biochemical and cellular assays investigating kinase inhibition and resistance mutations.
- High purity suitable for research applications.
- Soluble in DMSO; limited solubility in water.
- Active against Bcr-Abl and many resistance-associated mutants.
- Molecular weight 583.99 g/mol for formulation and dosing calculations.
- Supplied as a stable solid salt for ease of handling and storage.
Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.7% | 500.8 g/mol | C21H17ClF4N4O4 | 1 ML
Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor used in research. The item is provided as a 10 mM solution in a 1 mL vial for laboratory and analytical applications; it is intended for research use only.
- High purity suitable for research (purity 99.7%).
- Monohydrate form for consistent chemical properties.
- Concentrated solution (10 mM) enabling small-volume dosing.
- Convenient 1 mL vial for storage and handling.
- Useful as a kinase inhibitor in in vitro studies.
Apexbio Technology LLC Eltrombopag 496775-61-2 200mg
Eltrombopag is a small molecule orally bioavailable non-peptide agonist targeting the thrombopoietin (TPO) receptor also known as c-Mpl receptor Upon activating this receptor pathway eltrombopag promotes intracellular signaling leading to increased proliferation and differentiation of megakaryocyte progenitor cells thereby stimulating platelet production (thrombopoiesis) In biochemical assays eltrombopag shows potent activity exhibiting an IC50 value of approximately 0 69 M As a research tool this compound is utilized widely in studies investigating mechanisms regulating platelet homeostasis thrombocytopenia-related diseases and efforts to elucidate novel therapeutic strategies targeting hematopoietic lineage differentiation