Quinolines and derivatives
Medchemexpress LLC Urea, N-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1 | 219580-11-7 | MFCD08705327 | 99.9% | 523.7 g/mol | C28H41N7O3 | 200 MG
PD173074 is a small-molecule research compound that potently inhibits fibroblast growth factor receptor 1 (FGFR1). It shows an FGFR1 IC50 of ~25 nM, inhibits VEGFR2 with an IC50 of 100-200 nM, and demonstrates approximately 1,000-fold selectivity over PDGFR and c-Src. It is supplied for laboratory research use as an analytical/research standard.
- Potent FGFR1 inhibitor (IC50 ≈ 25 nM).
- Also inhibits VEGFR2 (IC50 100-200 nM).
- Approximately 1,000-fold selectivity for FGFR1 over PDGFR and c-Src.
- High purity (≈99.9%).
- Molecular weight 523.7 g/mol.
- CAS number 219580-11-7.
- For research use only.
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 100g
Methyl phenyl sulfone is a drug impurity
Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG
L-Azidonorleucine hydrochloride is an unnatural amino acid that serves as a methionine surrogate. It is used to label mammalian cell proteins and identify various methionyl-tRNA synthetase (MetRS) mutants. This compound functions as a click chemistry reagent due to its azide group, which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Unnatural amino acid and methionine surrogate
- Labels mammalian cell proteins
- Identifies methionyl-tRNA synthetase (MetRS) mutants
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 25g
Methyl phenyl sulfone is a drug impurity
Medchemexpress LLC Olumacostat glasaretil | 1261491-89-7 | 98.9% | 481.62 | 200 MG
Olumacostat glasaretil | 1261491-89-7 | 98.9% | 481.62 | 200 MG
TARGETMOL CHEMICALS INC TBA-7371 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6. purity: 99%
TARGETMOL CHEMICALS INC CP-466722 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CP-466722 an effective and reversible ATM inhibitor does not inhibit ATR and PI3K or PIKK family members in cells. purity: 99%
Medchemexpress LLC Pyrimethanil | 53112-28-0 | 99.9% | 200 MG
Pyrimethanil is an anilinopyrimidine and a broad-spectrum contact fungicide. It is used to control Botrytis species on various crops by inhibiting methionine biosynthesis in Botrytis cinerea. This compound is suitable for research aimed at preventing fungal diseases in fruit, vegetable, and ornamental plants with mold infections.
- Inhibits methionine and other amino acids biosynthesis in Botrytis cinerea.
- Aids research into preventing fungal diseases on fruit, vegetable, and ornamental plants.
- Decreases polygalacturonase, cellulase, proteinase, and laccase activities.
- Molecular weight: 199.25.
- Molecular formula: C12H13N3.
- Appearance: White to off-white solid.
Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.9% | 500.8 g/mol | C21H17ClF4N4O4 | 50 MG
Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor used as a research reagent and analytical standard. It exhibits potent inhibition of VEGFR, PDGFR, KIT, RET, and RAF kinases and is used in preclinical assays to study antitumor and antiangiogenic activity.
- High purity (≈99.9%) suitable for analytical work.
- Monohydrate form with molecular weight 500.8 g/mol.
- Useful as an analytical standard and research reagent in kinase assays.
- Available in small, quantified laboratory packages for preclinical studies.
Apexbio Technology LLC Nimorazole 200mg
Nimorazole (6506-37-2) is a nitroimidazole-based small-molecule radiosensitizer designed to enhance cellular radiosensitivity in hypoxic tumor environments Nimorazole exerts its biological activity primarily through metabolic reduction under hypoxic conditions forming reactive intermediates that interact with cellular DNA and augment the effects of radiation therapy In experimental studies nimorazole demonstrates radiosensitizing properties with IC50 values commonly reported in the low millimolar range in vitro although the exact value varies by cell line and context Based on these pharmacological properties nimorazole holds research potential in oncology applications particularly for investigating radiotherapeutic strategies targeting hypoxia-affected neoplastic tissues such as head and neck squamous cell carcinoma
Medchemexpress LLC Vardenafil | 224785-90-4 | 99.8% | 200 MG
Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while its IC50s are >1000 nM for PDE3 and PDE4. Vardenafil works by competitively inhibiting cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels.
- Potent and selective PDE5 inhibitor
- Increases cGMP levels through competitive inhibition
- Can be used for research of erectile dysfunction
- Can be used for research of hepatitis
- Can be used for research of diabetes
Apexbio Technology LLC Tideglusib 865854-05-3 200mg
Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity
Apexbio Technology LLC EMD638683 1181770-72-8 200mg
EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo